A5064759267- Dental Implant Techniques and Outcomes
- Cardiac Fibrosis and Remodeling
- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Mitochondrial Function and Pathology
- Cardiomyopathy and Myosin Studies
- Signaling Pathways in Disease
- Adipose Tissue and Metabolism
- Dental materials and restorations
- Bone Tissue Engineering Materials
- Dental Radiography and Imaging
- Advanced Glycation End Products research
- Cardiovascular Function and Risk Factors
- Nitric Oxide and Endothelin Effects
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Optical Network Technologies
- RNA Research and Splicing
- Nutrition and Health in Aging
- S100 Proteins and Annexins
- Geotechnical Engineering and Analysis
- Soil and Unsaturated Flow
- MicroRNA in disease regulation
- Periodontal Regeneration and Treatments
- Academic Writing and Publishing
Shanghai Ninth People's Hospital
2022-2025
Shanghai Jiao Tong University
2022-2025
Hubei Provincial Hospital of Traditional Chinese Medicine
2023-2025
Hubei University
2025
National Clinical Research
2025
Renmin Hospital of Wuhan University
2017-2024
Wuhan University
2017-2024
University of Hong Kong
2023
Hubei University of Chinese Medicine
2023
Stomatology Hospital
2022
Emerging evidence points to a two-way relationship between periodontitis and dietary choices and, thus, nutrition. This study aimed assess the potential cause-effect stage, loss of functional tooth units (FTUs), masticatory function, intake different food groups using path analysis.
Robot-assisted implant surgery has emerged as a novel digital technology, and the accuracy need further assessment.
Oxygen deficiency is associated with various oral diseases, including chronic periodontitis, age-related alveolar bone loss, and mechanical stress-linked cell injury from orthodontic appliances. Nevertheless, our understanding of the impact hypoxia on periodontal tissues its biochemical mechanism still rudimentary. The purpose this research was to elucidate effects apoptosis human ligament stem cells (PDLSCs) in vitro underlying mechanism. Herein, we showed that cobalt chloride (CoCl2)...
Our previous studies have shown that Src homology 2 (SH2) B adaptor protein 1 (SH2B1) plays an important role in cardiac hypertrophy, but the specific mechanism remains to be studied. Through bioinformatics and related research, it is found miR-14 2-3 p closely SH2B1. Exploring relationship between gene SH2B1 expression beneficial for treatment of hypertrophy. a key factor regulating energy metabolism, mitochondria are main organelles metabolism hypertrophy mitochondrial dysfunction. So...
Neutrophils, as first-line immune cells, typically lose their edge within the diabetic wounds accompanied by methicillin-resistant Staphylococcus aureus (MRSA) infections (the D/M setting), playing role of "more foe than friend" during healing process. Specifically, reduced influx calcium ions (Ca2+) and impaired homeostasis yield dysfunction neutrophil sequential behaviors in pathogen killing wound healing, manifesting suppressed chemotaxis, decreased intracellular reactive oxygen species...
Abstract Background In recent decades, the global life expectancy has risen notably to approximately 73.5 years worldwide, coinciding with a rapid growth in older adult population, which presents significant public health challenge promoting healthy aging and longevity. Objective This study aimed prospectively investigate link between edentulousness likelihood of reaching centenarian status among individuals aged 80 older. Methods Data from Chinese Longitudinal Healthy Longevity Survey were...
Abstract Aim Impairment of masticatory function in elderly patients with terminal dentition due to stage IV periodontitis (TDS4P) may lead lower nutritional intake. The study aimed report the dietary intake and nutrition status TDS4P compare them those Chinese population Dietary Reference Intakes (DRIs). Materials Methods Fifty‐one consecutive subjects (≥55 years old) were enrolled. Average was evaluated based on a 3‐day 24‐h recall (24HR) food frequency questionnaire (FFQ). daily fresh...
Abstract Background MicroRNAs (miRNAs) have been shown to commonly contribute cardiac hypertrophy (CH). The aim of this study was test the hypothesis that miR‐200c plays an important role in progression CH by targeting myosin light chain kinase (MLCK/MYLK). Methods and results Cardiac induced aortic banding (AB) rats. Cellular neonatal rat cardiomyocytes (NCMs) AngII treatment. Echocardiography, histology molecular measurements were used assess experiments. levels apoptosis reactive oxygen...
High mobility group box 1 (HMGB1) participates actively in oxidative stress damage and the latter relates closely to diabetic complications, including poor implant osseointegration. This article is aimed at investigating effects of HMGB1 on dysfunction bone marrow stromal cells (BMSCs) impaired osseointegration under environment. In vitro , BMSCs were treated with normal glucose (NG), high (HG), HG+glycyrrhizin (HMGB1 inhibitor, HG+GL). Cell proliferation, osteogenic behaviors, determined....
To evaluate the clinical, radiographic, and esthetic outcomes of immediate implant placement with buccal bone dehiscence in anterior maxilla.In this case series, implants were inserted immediately after tooth extraction sockets dehiscence. Guided regeneration (GBR) a papilla preservation flap simultaneous connective tissue grafting (CTG) was used. The following outcome variables measured: mid-facial mucosal recession, probing depth, bleeding on probing, Pink Esthetic Score (PES), marginal...
Angiotensin II (Ang II) has been shown to promote cardiac remodeling during the process of hypertrophy. Myosin light chain kinase (MLCK), a specific for phosphorylation myosin 2 (MLC2), plays an important role in regulating muscle contraction and However, whether Ang could facilitate hypertrophy by altering expression MLCK remains unclear. This study aimed investigate this effect underlying mechanisms.Cardiac was induced via pressure overload rats, which were then evaluated histological...
Shensong Yangxin Capsule (SSYX), traditional Chinese medicine, has been used to treat arrhythmias, angina, cardiac remodeling, fibrosis, and so on, but its effect on energy metabolism is still not clear. The objective of this study was investigate the effects SSYX myocardium in angiotensin (Ang) II-induced hypertrophy.We 2 μl (10-6 mol/L) AngII neonatal rat cardiomyocytes (NRCMs) for 48 h. Myocardial α-actinin staining showed that myocardial cell volume increased. Expression hypertrophic...
Compositions of resin composite exhibit cytotoxicity, especially Triethylene-glycol-dimethacrylate (TEGDMA), yet the underlying mechanisms and its relationship with filler content are poorly understood. Here, specimens five composites (VITA LC, VITA ZETA, Z350, Filtek P60, AP-X), containing different size weight, were immersed into culture medium for 72 h. After TEGDMA quantification, eluates used to incubate HGFs. Cellular viability was evaluated. Total reactive oxygen species (ROS)...
Diabetes and periodontitis are prevalent diseases that considerably impact global economy diabetes is a major risk factor of periodontitis. Mitochondrial dynamic alterations involved in many including this study aims to evaluate their relevance with aggravated Sixty mice randomly divided into 4 groups: control, periodontitis, diabetic Periodontitis severity evaluated by alveolar bone loss, inflammation oxidative stress status. structural functional defects the mitochondrial fission/fusion...
Local immunoinflammatory events instruct skeletal stem cells (SSCs) to repair/regenerate bone after injury, but mechanisms are incompletely understood. We hypothesized that specialized Regulatory T (Treg) necessary for repair and interact directly with SSCs through organ-specific messages. Both in human patients fracture mouse model of we identified a injury-responding Treg subpopulation bone-repair capacity marked by CCR8. production CCL1 induced massive migration CCR8+ from periphery the...
Background Loss of masticatory function consequent to tooth loss has been associated with changes in food choices and insufficient nutritional intake. To date, interventions based on dental prostheses alone did not significantly improve nutrient Pilot studies have shown positive impacts combining implant-supported fixed prosthesis brief dietary advice. The relative contribution the potential synergy components such need be determined as it major public health implications for...