A5100327766- Dental Implant Techniques and Outcomes
- Bone Tissue Engineering Materials
- Genetic Mapping and Diversity in Plants and Animals
- Dental Radiography and Imaging
- Orthopaedic implants and arthroplasty
- Dental materials and restorations
- Research in Cotton Cultivation
- Periodontal Regeneration and Treatments
- Bone Metabolism and Diseases
- Graphene and Nanomaterials Applications
- Oral microbiology and periodontitis research
- Advanced X-ray and CT Imaging
- Hip and Femur Fractures
- Medical and Biological Sciences
- Pain Mechanisms and Treatments
- Single-cell and spatial transcriptomics
- Total Knee Arthroplasty Outcomes
- Lung Cancer Treatments and Mutations
- Traditional Chinese Medicine Studies
- Retinal Diseases and Treatments
- Plant-based Medicinal Research
- Healthcare and Venom Research
- Orthodontics and Dentofacial Orthopedics
- Bone fractures and treatments
- Artificial Intelligence in Healthcare and Education
Shanghai Jiao Tong University
2013-2025
Shanghai Ninth People's Hospital
2016-2025
National Clinical Research
2021-2025
Chinese Academy of Agricultural Sciences
2022-2025
Institute of Animal Sciences
2025
Jiamusi University
2023-2024
Shanghai Stomatological Hospital
2022-2024
Shandong University
2024
National Clinical Research Center for Digestive Diseases
2021-2024
Harbin Medical University
2023-2024
While large language models (LLMs) such as ChatGPT and Google Bard have shown significant promise in various fields, their broader impact on enhancing patient health care access quality, particularly specialized domains oral health, requires comprehensive evaluation.
Abstract Although many studies have explored the benefits of empowering leadership for followers, beneficial effect such behavior actors who demonstrate has been overlooked. Applying conservation resources theory, we propose and test a model that determines why when actors. We use an experience sampling survey to examine on actors’ daily work engagement. In particular, focus moderating role power distance orientation mediating roles negative affect sleep quality, which operate sequentially....
Guided tissue regeneration (GTR) is a promising treatment for periodontal defects, which generally uses membrane to build mechanical barrier from the gingival epithelium and hold space especially tooth-supporting bone. However, existing membranes possess insufficient properties limited bioactivity bone regenerate. Herein, fish collagen polyvinyl alcohol (Col/PVA) dual-layer were developed via combined freezing/thawing layer coating method. This had clear but contact boundary line between PVA...
Periodontitis is a complicated inflammatory disease that damages the tooth-supporting tissues, with limited pharmacotherapy available. Macrophage-targeting therapy promising for diseases. Resveratrol (RSV), nonflavonoid polyphenol, known its anti-inflammatory and immunomodulatory effects. However, medical application by poor stability water-solubility, as well low bioavailability.
A hydrogel with improved interfacial compatibility was formed to promote osteogenesis by establishing electrostatic bonds.
To compare the biomechanical properties of proximal femur bionic nail (PFBN), femoral antirotation (PFNA) and InterTan in treatment elderly intertrochanteric fractures AO/OTA 31-A1.3 by finite element analysis.We used Mimics, Unigraphics other software to establish normal fracture models, reconstructed PFBN, PFNA intramedullary assembled them on model. The ANSYS was von Mises stress distribution, deformation internal fixation distribution each group under a load 2100 N.It could be seen that...
Pain is the most common symptom of bone cancer. TGF-β, a major bone-derived growth factor, largely released by osteoclast resorption during progression cancer and contributes to proliferation, angiogenesis, immunosuppression, invasion, metastasis. Here, we further show that TGF-β1 critical for cancer-induced pain sensitization. We found that, after cancer, was highly expressed in tumor-bearing bone, expression its receptors, TGFβRI TGFβRII, significantly increased DRG rat model based on...
Although tantalum (Ta)-based coatings have been proven to good antibacterial activity, the underlying mechanism and in vivo biological performance remain unclear, which are essential for clinical application of Ta-coated biomaterials as dental implants.The main objective this study is investigate activity Ta-modified titanium (Ti) implants against peri-implantitis-related microbes potential molecular mechanisms.Fusobacterium nucleatum Porphyromonas gingivalis were selected evaluate Ta...
Excessive production of reactive oxygen species (ROS) around titanium implants under diabetic conditions causes persistent inflammation, leading to poor osseointegration and even implant failure. Surface modification is an effective way promote ROS clearance, alleviate stimulate bone formation. In this study, a multifunctional coating fabricated by introducing cerium (Ce)-containing mesoporous bioactive glass nanoparticles (Ce-MBGNs) onto the surface via electrophoretic deposition method....
The rostral anterior cingulate cortex (rACC) is a key structure of pain affect. Whether and how estrogen in the rACC regulates pain-related negative emotion remains unclear. Behaviorally, using formalin-induced conditioned place aversion (F-CPA) rats, which believed to reflect emotion, we found that receptor (ER) inhibitor ICI 182, 780 (ICI, 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol) or aromatase androstatrienedione into completely blocked F-CPA...
Recent evidence suggests that estrogen is synthesized in the spinal dorsal horn and plays a role nociceptive processes. However, cellular molecular mechanisms underlying these effects remain unclear. Using electrophysiological, biochemical, morphological techniques, we here demonstrate 17β-estradiol (E2), major form of estrogen, can directly modulate cord synaptic transmission by 1) enhancing NMDA receptor-mediated neurons, 2) increasing glutamate release from primary afferent terminals, 3)...
Neutrophils, as first-line immune cells, typically lose their edge within the diabetic wounds accompanied by methicillin-resistant Staphylococcus aureus (MRSA) infections (the D/M setting), playing role of "more foe than friend" during healing process. Specifically, reduced influx calcium ions (Ca2+) and impaired homeostasis yield dysfunction neutrophil sequential behaviors in pathogen killing wound healing, manifesting suppressed chemotaxis, decreased intracellular reactive oxygen species...
Abstract Purpose The aim of the study was to evaluate clinical parameters and patient satisfaction treatments with short implants compared longer osteotome sinus floor elevation (OSFE) in atrophic posterior maxillae. Materials Method data were retrieved from an ongoing randomized controlled trial (NCT02350075). Patients randomly allocated into three groups: (group1: short‐6 mm implant, group 2: short‐8‐mm implant OSFE, 3: standard‐10 OSFE). Early failure, complications, stability quotient...
SH-1028 is an irreversible third-generation EGFR TKI. Both and osimertinib have a pyrimidine structure (a typical mutant-selective TKI structure). Compared with osimertinib, modified on the indole ring, thus resulting in more stable 6,7,8,9-tetrahydro-pyrrolo [1, 2-a] indol structure. In this study, we explored anti-tumor effect of vitro vivo , inhibition cell signal, such as ERK phosphorylation, verified relationship between pharmacokinetics pharmacodynamic responses. Firstly, selectively...
Local immunoinflammatory events instruct skeletal stem cells (SSCs) to repair/regenerate bone after injury, but mechanisms are incompletely understood. We hypothesized that specialized Regulatory T (Treg) necessary for repair and interact directly with SSCs through organ-specific messages. Both in human patients fracture mouse model of we identified a injury-responding Treg subpopulation bone-repair capacity marked by CCR8. production CCL1 induced massive migration CCR8+ from periphery the...
Protein is the basis of biological and cellular functions. Ca7Si2P2O16 (CSP) a new kind bioceramic with excellent apatite-mineralization osteostimulation properties; however, osteogenic mechanism CSP bioceramics unclear. Especially, effect on protein expression its possible signaling pathway unknown. In order to elucidate mechanism, bone-related expressions rat bone marrow stromal cells (rBMSCs) cultured disk extracts were systematically studied, in which we mainly investigated whether...
A new strategy for decreasing microleakage and improving the durability of dentin bonding interface by using a PU adhesive.