A5100424561- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- PARP inhibition in cancer therapy
- DNA Repair Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Cancer therapeutics and mechanisms
- Cancer Treatment and Pharmacology
- Cell death mechanisms and regulation
- Microbial Natural Products and Biosynthesis
- Molecular spectroscopy and chirality
- Animal Genetics and Reproduction
- Microtubule and mitosis dynamics
- Axial and Atropisomeric Chirality Synthesis
- Synthetic Organic Chemistry Methods
- Lung Cancer Treatments and Mutations
- Chemical synthesis and alkaloids
- Nanowire Synthesis and Applications
- Xenotransplantation and immune response
- Quinazolinone synthesis and applications
- CRISPR and Genetic Engineering
- Virus-based gene therapy research
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
China Pharmaceutical University
2016-2023
Simcere Pharmaceutical (China)
2020-2023
Wuhan University
2020
ZheJiang Institute For Food and Drug Control
2016
Introduction Genetically edited pigs, modified using CRISPR-Cas9 technology, hold promise as potential sources for xenotransplantation. However, the optimal combination of genetic modifications and their expression levels initial clinical trials remains unclear. This study investigates generation TKO/hCD55/hTM/hEPCR (6GE) pigs evaluates compatibility with human immune coagulation systems. Methods The 6GE were generated through iterative genome editing F1 breeding. Genotyping, flow cytometry,...
The development of a tumor-targeted immunotherapy is highly required. most advanced application the use CD19 chimeric antigen receptor (CAR)T (CAR-T) cells to B cell malignancies, but there are still side effects including potential carcinogenicity lentiviral or retroviral insertion into host genome. Here, we developed nonviral aptamer-T targeted strategy for tumor therapy. Tumor surface-specific ssDNA aptamers were conjugated CD3+T (aptamer-T cells) using N-azidomannosamine (ManNAz) sugar...
PARP7, a polyadenosine diphosphate-ribose polymerase, has been identified as negative regulator in type I interferon (IFN) signaling. An overexpression of PARP7 is typically found wide range cancers and can lead to the suppression IFN signaling innate immune response. Herein, we describe discovery compound I-1, novel inhibitor with high inhibitory potency (IC50 = 7.6 nM) selectivity for over other PARPs. Especially, I-1 excellent pharmacokinetic properties low toxicity mice exhibits...
SH-1028 is an irreversible third-generation EGFR TKI. Both and osimertinib have a pyrimidine structure (a typical mutant-selective TKI structure). Compared with osimertinib, modified on the indole ring, thus resulting in more stable 6,7,8,9-tetrahydro-pyrrolo [1, 2-a] indol structure. In this study, we explored anti-tumor effect of vitro vivo , inhibition cell signal, such as ERK phosphorylation, verified relationship between pharmacokinetics pharmacodynamic responses. Firstly, selectively...
Four novel taxane derivatives, N-debenzoyl-N-methyl-N-heptanoyl-taxol (1), N-debenzoyl-N-me-thyl-N-octanoyl-taxol (2), N-debenzoyl-N-methyl-N-(4-methylhexanoyl)-taxol (3), and N-debenzoyl-N-methyl-N-[(4Z)-1-oxo-4-tenenoyl]-taxol (4), were isolated from the ethanol extract of whole plant Taxus wallichiana.var.mairer. These structures identified on basis extensive spectroscopic analysis, their antitumor activity was evaluated against MCF-7, A549, 3-AO cancer cell lines by MTT method. Compound...
The construction of an N-C chiral axis for N-aryl indole derivatives is meaningful as they widely exist in functionalized molecules. This work provides a novel method this purpose via amination amino acid at the C2 position and center induced formation. protocol transformation easily accessible, not requiring metal or organic catalyst, endowing with great potential indoles.