A5100672092- Radiopharmaceutical Chemistry and Applications
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Advanced Glycation End Products research
- Neurological Disease Mechanisms and Treatments
- Bone and Joint Diseases
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Neonatal Respiratory Health Research
- Cancer, Hypoxia, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Phagocytosis and Immune Regulation
- Adenosine and Purinergic Signaling
- Immune Response and Inflammation
- Hair Growth and Disorders
- Bone Tumor Diagnosis and Treatments
- Immune Cell Function and Interaction
- Mitochondrial Function and Pathology
- Pancreatic and Hepatic Oncology Research
- Oral and Maxillofacial Pathology
- Cerebral Palsy and Movement Disorders
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Pediatric health and respiratory diseases
- Redox biology and oxidative stress
Sichuan University
2018-2024
Chengdu University of Traditional Chinese Medicine
2024
State Key Laboratory of Biotherapy
2024
Beijing University of Chinese Medicine
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
First Affiliated Hospital of Xiamen University
2015-2023
Fujian Medical University
2023
Xiamen University
2023
State Key Laboratory of Oral Diseases
2018-2022
Peking Union Medical College Hospital
2022
Hair morphogenesis takes place through reciprocal epithelial and mesenchymal signaling; however, the mechanisms controlling signal exchange are poorly understood. Laminins extracellular proteins that play critical roles in adhesion signaling. Here we demonstrate mechanism of how laminin-511 controls hair morphogenesis. Dermal papilla (DP) from mutants showed developmental defects by E16.5, including a failure to maintain expression key morphogen noggin. This maintenance was as exogenous...
To evaluate the short-term outcomes in terms of tumor control and toxicity patients with skull base or cervical spine chordoma chondrosarcoma treated intensity-modulated proton carbon-ion radiation therapy.Between 6/2014 7/2018, a total 91 were our Center. The median age was 38 (range, 4-70) years. Forty-six (50.5%) definitively for their conditions as initial diagnosis, 45 (49.5%) had recurrent tumors including 14 prior radiotherapy. gross volume 37.0 1.6-231.7) cc. Eight received therapy...
Sirtuin 3 (SIRT3), a mitochondrial NAD+ -dependent deacetylase, has received much attention for its effect on metabolism and aging. However, the role of SIRT3 in periodontal disease remains unknown.This study aimed to investigate functional age-related underlying mechanisms.Sixteen mice were randomly assigned into four groups: young wild type (WT), aged WT, SIRT3-knockout (KO), SIRT3-KO. cyclophilin D (CypD) expression protein lysine acetylation levels alveolar bones detected by western...
High mobility group box 1 (HMGB1) participates actively in oxidative stress damage and the latter relates closely to diabetic complications, including poor implant osseointegration. This article is aimed at investigating effects of HMGB1 on dysfunction bone marrow stromal cells (BMSCs) impaired osseointegration under environment. In vitro , BMSCs were treated with normal glucose (NG), high (HG), HG+glycyrrhizin (HMGB1 inhibitor, HG+GL). Cell proliferation, osteogenic behaviors, determined....
Background: Sinonasal adenoid cystic carcinoma (SNACC) presents a challenge to oncologists due its complex anatomy and poor prognosis. Although radiation therapy, either definitive or adjuvant surgery, is an important part of the multidisciplinary management SNACC, photon-based radiotherapy yielded suboptimal local control. The purpose this study was report clinical results large patient cohort treated with particle beam therapy. Methods: Patients SNACC that received proton therapy (PBT),...
The interleukin-1 (IL-1) signaling pathway plays a vital role in multiple mechanisms associated with myocardial ischemia-reperfusion (I/R) injury, including inflammation and apoptosis. An IL-1 receptor antagonist (IL-1Ra) can block by competitive binding to the type I (IL-1RI) thus may provide cardioprotective effect. In present investigation, we determined whether exogenous administration of recombinant human IL-1Ra (rhIL-1Ra) provides protective against I/R injury. Sprague-Dawley rats...
Compositions of resin composite exhibit cytotoxicity, especially Triethylene-glycol-dimethacrylate (TEGDMA), yet the underlying mechanisms and its relationship with filler content are poorly understood. Here, specimens five composites (VITA LC, VITA ZETA, Z350, Filtek P60, AP-X), containing different size weight, were immersed into culture medium for 72 h. After TEGDMA quantification, eluates used to incubate HGFs. Cellular viability was evaluated. Total reactive oxygen species (ROS)...
In some inflammatory diseases of bone, osteogenesis and osteoclasis are uncoupled the balance is usually tipped resulting in bone destruction. The underlying mechanism osteogenic dysfunction inflammation still needs further study. This study aimed at investigating effects cyclosporine A (CsA) on remodeling lipopolysaccharide‐ (LPS‐) related inflammation. vivo , an alveolar defect model was established using 10‐week‐old C57BL/6J mice. mice were divided into phosphate‐buffered saline (PBS),...
Antioxidant systems like thioredoxin (Trx) and glutaredoxin (Grx) maintain oxidative stress balance. These have cross-talk supported by some
What is the central question of this study? Does leptin have an effect on hypoxia-induced apoptosis in human periodontal ligament cells (hPDLCs), and what potential underlying mechanism? main finding its importance? Hypoxia induces cell expression hPDLCs through induction hypoxia-inducible factor-1α accumulation reactive oxygen species (ROS). Leptin shows feedback inhibition ROS-mediated hPDLCs, suggesting a new application for hypoxic damage diseases.Hypoxia-induced (hPDLCs) important...