A5101886487- Pharmaceutical and Antibiotic Environmental Impacts
- Constructed Wetlands for Wastewater Treatment
- Advanced biosensing and bioanalysis techniques
- Lung Cancer Treatments and Mutations
- DNA and Nucleic Acid Chemistry
- Heat shock proteins research
- Nanoplatforms for cancer theranostics
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Turfgrass Adaptation and Management
- Lung Cancer Research Studies
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Inflammatory Bowel Disease
- Luminescence and Fluorescent Materials
- Molecular Sensors and Ion Detection
- Pneumonia and Respiratory Infections
- Physiological and biochemical adaptations
- Sulfur-Based Synthesis Techniques
- Seed Germination and Physiology
- RNA Research and Splicing
- Genetic factors in colorectal cancer
Hubei University
2025
Taizhou Central Hospital
2012-2024
Taizhou University
2022-2024
China-Japan Friendship Hospital
2021-2024
Suzhou Traditional Chinese Medicine Hospital
2024
Ming Wai Lau Centre for Reparative Medicine
2021-2022
Hebei Agricultural University
2019-2021
Wuhan University
2019
Sichuan University
2017
State Key Laboratory of Oral Diseases
2017
Abstract Dual inhibition of vascular endothelial growth factor and epidermal receptor (EGFR) signaling pathways offers the prospect improving effectiveness EFGR-targeted therapy. In this phase 3 study (ClinicalTrial.gov: NCT04028778), 315 patients with treatment-naïve, EGFR- mutated, advanced non-small cell lung cancer (NSCLC) were randomized (1:1) to receive anlotinib or placebo plus gefitinib once daily on days 1–14 per a 3-week cycle. At prespecified final analysis progression-free...
The reintroduction of the pseudorabies virus (PRV) has led to emergence epidemics in some pig farms China, resulting significant economic losses. Moreover, number human infections with PRV increased. Therefore, research into prevention and treatment strains is imperative. In this work, DNA polymerase (DNA pol) was found exhibit a high degree sequence structural similarity herpes simplex 1 (HSV-1) pol. Consequently, we provided first experimental evidence that PNU-183792, non-nucleoside...
Abstract Antibacterial photodynamic therapy (PDT) is one of the emerging methods for curbing multidrug‐resistant bacterial infections. Effective fluorescent photosensitizers with dual functions bacteria imaging and PDT applications are highly desirable. In this study, three cationic heteroleptic cyclometalated Ir(III) complexes formula [Ir(CˆN) 2 (NˆN)][PF 6 ] prepared characterized. These named Ir(ppy) bP , Ir(1‐pq) bP, Ir(2‐pq) comprised CˆN ligands (i.e., 2‐phenylpyridine (ppy),...
To evaluate the value of nanopore targeted sequencing in diagnosing pneumonia pathogens.This large-scale multicentre prospective study performed 8 hospitals across China from April to October 2022. Hospitalised patients with a diagnosis at admission were included. Complete clinical data collected, and bronchoalveolar lavage fluid obtained each patient. These samples underwent simultaneous testing using conventional microbial testing, metagenomic next-generation sequencing, sequencing.A total...
Abstract Background Small heat shock proteins (sHSPs) are critical for plant response to biotic and abiotic stresses, especially stress. They have also been implicated in various aspects of development. However, the acting mechanisms sHSPs plants, perennial grass species, remain largely elusive. Results In this study, AsHSP26.8a , a novel chloroplast-localized sHSP gene from creeping bentgrass ( Agrostis stolonifera L.) was cloned its role environmental stress studied. encodes protein 26.8...
Although previous studies have implicated pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), to be detrimental for osteogenic activity, the related regulatory mechanisms are not yet fully validated. Since mitochondria host several essential metabolic processes play a pivotal role in cellular functions, whether how mitochondrial function contributes inflammation-induced bone destruction needs further exploration. Our findings revealed that TNF-α...
Small heat shock proteins (sHSPs), a family of the ubiquitous stress in plants acting as molecular chaperones to protect other from stress-induced damage, have been implicated plant growth and development well response environmental stress, especially stress. In this study, chloroplast-localized sHSP, AsHSP26.8, was overexpressed creeping bentgrass (Agrostis stolonifera L.) study its role regulating response. Transgenic (TG) displayed arrested root development, slow rate, twisted leaf blades...
Thermosensitive and imaging-traceable materials with fine-tunable lower critical solution temperature (LCST) around body are highly valuable in biomedicine. However, such rare because it is challenging to fine-tune the LCST incorporate suitable imaging modalities. Herein, peptidic monodisperse polyethylene glycol (M-PEG) "combs" LCST, "hot spot" fluorine-19 magnetic resonance (19F MRI), thermoresponsive fluorescent imaging, drug loading ability were developed through accurately programming...
Parallel and anti-parallel T–Hg–T base pairs have different thermal stabilities conformational influences on DNA duplex structures.
Chromosome 8q24 is commonly amplified in many types of cancer, particularly lung cancer. Polymorphisms this region are associated with risk different cancers. To investigate the relationship between three single nucleotide polymorphisms (SNPs) (rs1447295, rs16901979 and rs6983267) on cancer risk, we conducted an association study two Han Chinese populations: one population was from Zhejiang Province (576 case patients 576 control subjects), whereas other Fujian subjects). We found that...
Epidermal growth factor receptor‑tyrosine kinase inhibitors, such as gefitinib, have been found to be clinically effective in the treatment of patients with non‑small cell lung cancer (NSCLC). However, therapeutic effect gefitinib is often limited by development resistance. MicroRNAs (miRNAs), a group small non‑coding RNAs, demonstrated frequently dysregulated human malignancies. For instance, downregulation miR‑506‑3p has reported NSCLC patients. The aim present study was determine role and...
To investigate the correlations between expressions of proto-oncogenes C-myc and B-cell-specific Moloney leukemia virus integration site-1 (BMI-1), vaginal microecology, human papillomavirus-DNA (HPV-DNA) load in patients with different cervical lesions.
Atypical L858R or other L858X mutations in the epidermal growth factor receptor (EGFR) gene, beyond classical EGFR