A5062919693- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- 3D Printing in Biomedical Research
- Advanced Drug Delivery Systems
- Cancer Cells and Metastasis
- Metabolomics and Mass Spectrometry Studies
- Advancements in Transdermal Drug Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Tissue Engineering and Regenerative Medicine
- Lipid Membrane Structure and Behavior
- Electrospun Nanofibers in Biomedical Applications
- Neurotransmitter Receptor Influence on Behavior
- Mitochondrial Function and Pathology
- Eicosanoids and Hypertension Pharmacology
- Innovative Microfluidic and Catalytic Techniques Innovation
- Neuroscience and Neuropharmacology Research
- Corneal Surgery and Treatments
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Drug Solubulity and Delivery Systems
- RNA modifications and cancer
- Inhalation and Respiratory Drug Delivery
- Fatty Acid Research and Health
- Corneal surgery and disorders
- Inflammatory mediators and NSAID effects
National Institute of Pharmaceutical Education and Research
2023-2025
Indian Institute of Technology Delhi
2018-2024
Maitama Sule University Kano
2023
Aligarh Muslim University
2023
Manouba University
2023
Babasaheb Bhimrao Ambedkar University
2014-2022
Miragen Therapeutics (United States)
2019-2022
Translational Health Science and Technology Institute
2018-2020
University of Lucknow
2016-2018
Howard University
1978
Angiogenesis plays a significant role in the human body, from wound healing to tumor progression. "Angiogenic switch" indicates time-restricted event where imbalance between pro- and antiangiogenic factors results transition prevascular hyperplasia outgrowing vascularized tumor, which eventually leads malignant cancer In last decade, molecular players, i.e., angiogenic biomarkers underlying pathways involved tumorigenesis, have been intensely investigated. Disrupting initiation halting...
Abstract In recent years, engineering biomimetic cellular microenvironments have been a top priority for regenerative medicine. Collagen II, which is arranged in arches, forms the predominant fiber network articular cartilage. Due to shortage of suitable microfabrication techniques capable producing 3D fibrous structures, vitro replication arch-like cartilaginous tissue constitutes one major challenges. Hence, present study, we report bioprinting approach fabricating constructs using two...
A novel ultra-short peptide hydrogelator capable of exhibiting excellent aggregation-induced emission and biocompatible features that have been exploited for in vitro cellular imaging.
Alpha linolenic acid is an essential polyunsaturated fatty and reported to have the anti-cancer potential with no defined hypothesis or mechanism/s. Henceforth present study was in-quested validate effect of alpha on mitochondrial apoptosis, hypoxic microenvironment de novo synthesis using in-vitro in-vivo studies. The IC50 value recorded be 17.55μM against ER+MCF-7 cells. Treatment evident for presence early late apoptotic signals along depolarization, when studied through acridine...
Rifampicin (RIF) and Isoniazid (INH) are two major first-line antitubercular drugs (ATDs) that typically administered orally, in combination. However, INH-catalysed degradation of RIF under acidic pH environment the stomach is a concern related to its oral delivery, dramatically accelerated upon further exposure interaction with INH. This interaction, turn, triggers direct decline available dose below sub-therapeutic level, thereby diminishing therapeutic efficacy. We hypothesized...
Dual-drug-loaded lipid nanoparticle formulations (LNFs) namely solid nanoparticles (SLNs) and nanostructured carrier (are also nanoparticles- a new generation of traditional SLNs) were developed delivered to differentiated THP-1 cells. Developed LNFs have smooth spherical surface morphology nano range in size. In vitro drugs release profiles from these slow sustained. Particles well co-localised different compartment (lysosome endosome) polarised macrophage by using suitable pH-dependent...
In vitro models are necessary to study the pathophysiology of disease and development effective, tailored treatment methods owing complexity heterogeneity breast cancer large population affected by it. The cellular connections tumor microenvironments observed in vivo often not recapitulated conventional two-dimensional (2D) cell cultures. Therefore, developing 3D that mimic complex architecture physiological circumstances tumors is crucial for advancing our understanding illness. A...
3D bioprinting has the potential for rapid and precise engineering of hydrogel constructs that can mimic structural optical complexity a healthy cornea. However, use existing light-activated bioinks corneal printing is limited by their poor cytocompatibility, cytotoxic photoinitiators (PIs), low photo-crosslinking efficiency, opaque/colored surface printed material. Herein, we report fast-curable, non-cytotoxic, optically transparent system using new water-soluble benzoyl phosphinate-based...
The present study was in quested to the effects of β-sitosterol on methyl nitrosourea (MNU) induced mammary gland carcinoma albino wistar rats. Animals were randomized and divided into four groups eight animals each. Group I (sham control 1 % CMC normal saline p.o.); II (toxic control, MNU 47 mg/kg, i.v); III (MNU i.v + β-sitosterol, 10 p.o); IV 20 p.o). Toxicity by single i.v. injection followed supplementation therapy for 115 days at dose mentioned above. Treatment with evidenced decrease...
Isoniazid is an important first-line antitubercular drug used in the treatment of all major clinical manifestations tuberculosis, including both pulmonary and cerebral diseases. However, it associated with significant drawbacks due to its inherent hydrophilic nature, poor gut permeability inability cross lipophilic blood–brain barrier, which, turn, limit efficacy. We hypothesized that addition a hydrophobic moiety this molecule would help overcome these limitations improve bioavailability...
We investigated the plasticity and polarization of THP-1 cells on native regenerated silk-based biomaterials to address basic paradigm immune response. Here, we report redox kinetics, adhesion morphology, nitric oxide release patterns identify specific subtypes macrophages at different time points. Water-annealed silk film fibrous braids from Bombyx mori silkworms showed higher anti-inflammatory cytokine profiles or M2 (as evidenced by enhanced expression interleukin-10, interleukin-13,...
The molecular niche of an osteoarthritic microenvironment comprises the native chondrocytes, circulatory immune cells, and their respective inflammatory mediators. Although M2 macrophages infiltrate joint tissue during osteoarthritis (OA) to initiate cartilage repair, mechanistic crosstalk that dwells underneath is still unknown. Our study established a co-culture system human OA chondrocytes in 3D spheroids bioprinted silk-gelatin constructs. It already well Silk fibroin-gelatin bioink...
Abstract In terms of biomedical tools, nanodiamonds (ND) are a more recent innovation. Their size typically ranges between 4 to 100 nm. ND produced via variety methods and known for their physical toughness, durability, chemical stability. Studies have revealed that surface modifications functionalization significant influence on the optical electrical properties nanomaterial. Consequently, functional groups NDs applications in domains, including drug administration, gene delivery,...
Selenium nanoparticle-functionalized injectable chitosan/collagen hydrogels for bone regeneration.