A5003713153- Chemotherapy-induced organ toxicity mitigation
- Uterine Myomas and Treatments
- Metabolism and Genetic Disorders
- Curcumin's Biomedical Applications
- Endometriosis Research and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Potato Plant Research
- Liver physiology and pathology
- Liver Disease Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Genomics, phytochemicals, and oxidative stress
- Cell death mechanisms and regulation
- Nigella sativa pharmacological applications
- Renal and related cancers
- Pharmacological Effects of Medicinal Plants
- Sulfur Compounds in Biology
- Gynecological conditions and treatments
- Inhalation and Respiratory Drug Delivery
- Tendon Structure and Treatment
- Paraoxonase enzyme and polymorphisms
- Alcoholism and Thiamine Deficiency
- Electromagnetic Fields and Biological Effects
- Biofield Effects and Biophysics
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Ahram Canadian University
2019-2021
Modern University for Information and Technology
2016
Al-Azhar University
2008-2009
Al-Azhar University
2002-2009
Cancer Institute (WIA)
2005
Cairo University
2005
Low dose methotrexate is the cornerstone for treatment of rheumatoid arthritis. One its major drawbacks hepatotoxicity, resulting in poor compliance therapy. Dissatisfied arthritis patients are likely to seek option complementary and alternative medicine such as bee venom. The combination natural products with modern poses possibility potential interaction between two groups needs investigation. present study was aimed investigate modulatory effect venom acupuncture on efficacy, toxicity,...
The possible uroprotective effects of curcumin have been addressed in the current study. Haemorrhagic cystitis was induced by challenging male Swiss albino rats with a single dose cyclophosphamide (150 mg/kg, i.p.). Curcumin (200 i.p.) administered for 10 consecutive days followed cyclophosphamide. well characterized morphologically and biochemically. hallmark this toxicity marked congestion, oedema extravasation rat urinary bladder, as desquamative damage to urothelium severe inflammation...
In the field of environmental toxicology, endocrine-disrupting effects have become a major concern. The present research set out to investigate possible reproductive toxicity acrylamide. was also expanded explore protective two nutraceuticals, thymoquinone (TQ) and capsaicin, against acrylamide-induced toxicity. Six groups sixty male albino rats were created. Group 1 used as control. Rats administered daily dose acrylamide acted model in 2. TQ provided once day 3. Capsaicin 4. given exposed...
Context: Human uterine leiomyomas are very common smooth muscle cell tumors that occur in reproductive-age women and the leading reason for performing hysterectomies. The present study was conducted to explore potential mechanism behind effects exerted by dominant-negative estrogen receptors (DNERs) delivered adenovirus leiomyoma cells ascertain utility of DNERs as a novel strategy treatment fibroids.
In the present study, we have addressed possible protective role of acetyl-L-carnitine in caerulein-induced acute pancreatitis male Swiss albino rats. Acute paradigm was developed by challenging animals with a supramaximal dose caerulein (20 microg/kg, SC) four times at hourly intervals. Caerulein induced that well-characterized morphologically and biochemically. Severe oedema marked increased relative pancreatic weight, atrophy acini interacinar spaces, vacuolization, extensive leucocytic...
<i>Background/Aims:</i> The objective of this study was to assess in vivo gene therapy uterine leiomyomas the Eker rat model using adenovirus (Ad)-mediated delivery herpes simplex virus 1 thymidine kinase (HSV1TK) followed by ganciclovir (GCV) treatment. <i>Methods:</i> We randomized 27 female rats with MRI-confirmed a single treatment direct intra-tumor injection Ad-HSV1TK/GCV, Ad-LacZ/GCV, or medium alone. Samples were collected from tumors, other body organs, and...
To circumvent the paucity of primary adenovirus (Ad5) receptor and non-specific Ad5 tropism in context uterine leiomyoma cells, modification strategies would be beneficial.We screened several modified adenoviruses to identify most efficient selective virus toward human cells used as candidate for delivering therapeutic genes. We propagated: wild-type Ad5-luc, fiber-modified viruses: ad5 RGD-luc, Ad5-Sigma-luc, Ad5/3-luc Ad5-CAV2-luc, well transcriptional targeted survivin-luc,...
Background. Glufosfamide (GLU) is a glucose conjugate of ifosfamide in which isophosphoramide mustard glycosidically linked to the β-D-glucose molecule. Based on GLU structure, it considered targeted chemotherapy with fewer side effects. The main objective current study assess cytotoxic potential for first time prostate cancer (PC) cells representing different stages tumor. Furthermore, this examined synergistic activity combination docetaxel (DOC). Methods. Two cell lines were used, LNCaP...
Peptic ulcers are one of the world's major gastrointestinal disorders, embracing both gastric and duodenal ulcers, affecting 10% world population. The current study aimed to investigate possible protective effect tadalafil pentoxifylline (PTX) on indomethacin-induced peptic ulcers. Male albino rats were divided into five groups: control group; ulcerated Indomethacin + Tadalafil, in which animals pretreated with orally before indomethacin; Indomethacin+ PTX, PTX Tadafil PTX. treatment...