A5044499133- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Cancer-related cognitive impairment studies
- Drug-Induced Hepatotoxicity and Protection
- Reproductive Biology and Fertility
- Tryptophan and brain disorders
- Bioactive Compounds and Antitumor Agents
- Chemotherapy-induced cardiotoxicity and mitigation
- Ovarian function and disorders
- Genomics, phytochemicals, and oxidative stress
- Chemotherapy-induced organ toxicity mitigation
- Estrogen and related hormone effects
- Brain Metastases and Treatment
- Cancer Treatment and Pharmacology
- Diet, Metabolism, and Disease
- Glioma Diagnosis and Treatment
- Phytochemicals and Antioxidant Activities
- Pesticide Exposure and Toxicity
- Cancer, Lipids, and Metabolism
- Stress Responses and Cortisol
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Microbial metabolism and enzyme function
Ain Shams University
2016-2025
King Saud University
2021
Misr International University
2016
Galveston College
2008-2010
National Center for Environmental Assessment (EPA)
2008
Meharry Medical College
2008
Doxorubicin (DOX) is the mainstay chemotherapeutic agent against a variety of human neoplasmas. However, its clinical utility limited by marked cardiotoxicity. Chrysin, natural flavone which possesses antioxidant, anti-inflammatory and anti-cancer properties. The current study aimed to investigate potential protective effect chrysin DOX-induced chronic cardiotoxicity underlying molecular mechanisms. Male Sprague-Dawley rats were treated with either DOX (5 mg/kg, once week) and/or (50 four...
Low dose methotrexate is the cornerstone for treatment of rheumatoid arthritis. One its major drawbacks hepatotoxicity, resulting in poor compliance therapy. Dissatisfied arthritis patients are likely to seek option complementary and alternative medicine such as bee venom. The combination natural products with modern poses possibility potential interaction between two groups needs investigation. present study was aimed investigate modulatory effect venom acupuncture on efficacy, toxicity,...
Background and Purpose Liver fibrosis is one of the leading causes morbidity mortality worldwide with very limited therapeutic options. Given pivotal role activated hepatic stellate cells in liver fibrosis, attention has been directed towards signalling pathways underlying their activation fibrogenic functions. Recently, hedgehog (Hh) pathway identified as a potentially important target fibrosis. The present study was designed to explore antifibrotic effects potent Hh inhibitor, forskolin,...
Biochanin A (BCA) is an isoflavone found in red clover possessing multiple pharmacological activities including antimicrobial, antioxidant, and anticancer ones. The present study aimed to assess its hepatoprotective potential at different doses a carbon tetrachloride (CCl4)-induced hepatotoxicity model rats. effects on hepatic injury were explored by measuring serum levels of alanine aminotransferase, aspartate alkaline phosphatase. Furthermore, the glucose, urea, creatinine, total...
Abstract This study was carried out to investigate the potential therapeutic effect of galangin, a promising active principle honeybee propolis, in dextran sulphate sodium (DSS)–induced colitis mice. We explored possible underlying mechanisms for galangin action and benefit adding standard therapy sulphasalazine. A dose 40 mg/kg selected based on preliminary dose‐selection investigation 4‐week cyclical model DSS‐induced colitis. Mice received 3% DSS their drinking water during first third...
Cisplatin (CP) is a broad-spectrum antineoplastic agent used to treat many human cancers. Nonetheless, most patients receiving CP suffer from cognitive deficits, phenomenon termed "chemo-brain". Recently, vildagliptin (Vilda), DPP-4 inhibitor, has demonstrated promising neuroprotective properties against various neurological diseases. Therefore, the present study aims investigate potential of Vilda CP-induced neurotoxicity and elucidate underlying molecular mechanisms. Chemo-brain was...
Abstract Background High intake of dietary fructose is accused being responsible for the development insulin resistance (IR) syndrome. Concern has arisen because realization that fructose, at elevated concentrations, can promote metabolic changes are potentially deleterious. Among these IR which manifests as a decreased biological response to normal levels plasma insulin. Methods Oral glucose tolerance tests (OGTT) were carried out, homeostasis model assessment (HOMA) was calculated,...
Radiotherapy is a major factor contributing to female infertility by inducing premature ovarian failure (POF). Therefore, the need for an effective radioprotective agent evident. The present study investigated mechanism of potential effect sodium selenite on radiation-induced and whether can stimulate in-vivo follicular development in experimental rats. Immature Sprague-Dawely rats were either exposed gamma-radiation (3.2 Gy, LD20), once and/or treated with (0.5 mg/kg), daily one week before...
The use of doxorubicin (DOX) to treat various tumors is limited by its cardiotoxicity. This study aimed investigate and compare the cardioprotective effects nicotinamide (NAM) alfacalcidol (1α(OH)D3), against DOX-induced Sprague Dawley male rats received DOX (5 mg/kg, i.p.) once/week for four consecutive weeks. Treated groups either NAM (600 p.o.) 28 days or 1α(OH)D3 (0.5 ug/kg, elicited marked cardiac tissue injury manifested elevated serum cardiotoxicity indices, conduction...