A5077509035- Eicosanoids and Hypertension Pharmacology
- Hormonal Regulation and Hypertension
- Pharmacogenetics and Drug Metabolism
- Liver Disease Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- Nitric Oxide and Endothelin Effects
- Alcohol Consumption and Health Effects
- Liver physiology and pathology
- Bioactive natural compounds
- Sphingolipid Metabolism and Signaling
- Phytochemicals and Antioxidant Activities
- Essential Oils and Antimicrobial Activity
- Bee Products Chemical Analysis
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Estrogen and related hormone effects
- Natural Antidiabetic Agents Studies
- Pharmacological Effects of Natural Compounds
- Analytical Chemistry and Chromatography
- Moringa oleifera research and applications
University of Alberta
2021-2025
Ain Shams University
2017-2021
Cytochrome P450 (P450) enzymes are monooxygenases that expressed hepatically and extrahepatically play an essential role in xenobiotic metabolism. Substantial scientific evidence indicates sex-specific differences between males females disease patterns drug responses, which could be attributed, even partly, to the expression and/or activity levels of different organs. In this study, we compared mRNA protein organs male female Sprague-Dawley rats by real-time polymerase chain reaction western...
Abstract This study was carried out to investigate the potential therapeutic effect of galangin, a promising active principle honeybee propolis, in dextran sulphate sodium (DSS)–induced colitis mice. We explored possible underlying mechanisms for galangin action and benefit adding standard therapy sulphasalazine. A dose 40 mg/kg selected based on preliminary dose‐selection investigation 4‐week cyclical model DSS‐induced colitis. Mice received 3% DSS their drinking water during first third...
Distinct differences between sexes exist in various cardiovascular diseases. Moreover, there is a significant correlation the pathogenesis of cardiac hypertrophy (CH) and metabolites arachidonic acid (AA) mediated by cytochrome P450 (CYP) enzymes. The potential link these sex differences, levels activity CYP enzymes, their AA-mediated remains to be elucidated. Male female Sprague Dawley rats were injected with 1 mg/kg isoproterenol for 7 days induce CH. Echocardiography was performed before...
Heart failure (HF) is preceded by cellular hypertrophy (CeH) which alters expression of cytochrome P450 enzymes (CYPs) and arachidonic acid (AA) metabolism. Inflammation involved in CeH pathophysiology, but mechanisms remain elusive. This study investigates the impacts tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), lipopolysaccharides (LPS) on development role CYP1B1. AC16 cells were treated with TNF-α, IL-6, LPS presence absence CYP1B1-siRNA or resveratrol. mRNA protein levels...
Aryl hydrocarbon receptor (AhR) is a multifunctional that regulates cytochrome P450 1A1 (CYP1A1), an arachidonic acid (AA) metabolizing enzyme producing 19-hydroxyeicosatetraenoic (HETE). 6-formylindolo[3,2-b]carbazole (FICZ) demonstrates great affinity toward the AhR. Recently, we have shown 19(S)-HETE preferentially cardioprotective. This study investigates role of FICZ on AhR and (CYP) 1A1-mediated AA metabolism whether it attenuates angiotensin (Ang) II-induced cardiac hypertrophy. Adult...
The phenomenon of chirality has been shown to greatly impact drug activities and effects. Different enantiomers may exhibit different effects in a certain biological condition or disease state. Cytochrome P450 (CYP) enzymes metabolize arachidonic acid (AA) into large variety metabolites with wide range activities. Hydroxylation AA by CYP hydroxylases produces hydroxyeicosatetraenoic acids (HETEs), which are classified mid-chain (5, 8, 9, 11, 12, 15-HETE), subterminal (16-, 17-, 18- 19-HETE)...
Menopause is a normal stage in the human female aging process characterized by cessation of menstruation and ovarian production estrogen progesterone hormones. associated with an increased risk several different diseases. Cardiovascular diseases are generally less common females than age-matched males. However, this advantage lost after menopause. Cardiac hypertrophy disease cardiac size that develops as response to chronic overload or stress. Similar other cardiovascular diseases,...
Hydroxyeicosatetraenoic acids (HETEs) are hydroxylated arachidonic acid (AA) metabolites that classified into midchain, subterminal, and terminal HETEs. Hydroxylation results in the formation of R S enantiomers for each HETE, except 20-HETE. HETEs have multiple physiological pathological effects. Several studies demonstrated sex-specific differences AA metabolism different organs. In this study, microsomes from heart, liver, kidney, lung, intestine, brain adult male female Sprague-Dawley...
Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD), characterized by chronic inflammation the gastrointestinal tract. In general, IBD more common in Western than Eastern places, and industrialized developing countries. However, incidence has been rising recently countries including Egypt. Symptoms include loss appetite, tenesmus, abdominal cramps, diarrhea, bloody stools. Available treatment options drugs, surgery, or combination both. One most commonly used drugs for...