A5043148455- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related cognitive impairment studies
- MicroRNA in disease regulation
- Brain Metastases and Treatment
- Extracellular vesicles in disease
- Immune cells in cancer
- Glioma Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Genetic and Kidney Cyst Diseases
- Hepatitis C virus research
- Tryptophan and brain disorders
- Trace Elements in Health
- Iron Metabolism and Disorders
- Amino Acid Enzymes and Metabolism
- Cancer-related molecular mechanisms research
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Diet, Metabolism, and Disease
- Endoplasmic Reticulum Stress and Disease
- Adenosine and Purinergic Signaling
- Silk-based biomaterials and applications
- Lipid metabolism and biosynthesis
- Curcumin's Biomedical Applications
University of Michigan
2022-2024
Ain Shams University
2011-2024
Michigan United
2023
Diabet. Med. 28, 1194–1200 (2011) Aims Omentin-1 and chemerin have been identified as interesting novel adipokines that may modulate insulin action. Also, they suggested to be linked obesity-induced resistance. The aim of this study was analyse the relationship between these interleukin-6, resistance anthropometric metabolic variables in patients with Type 2 diabetes mellitus who ischaemic heart disease. Methods Seventy-five individuals 15 healthy control subjects were enrolled study....
Improving prediction of treatment outcomes in chronic hepatitis C (CHC) genotype 4 (G4) is necessary to increase sustained viral response (SVR) rates. Vitamin D related and interferon stimulated genes are good candidates as they recently crosstalk altering response. Thus single nucleotide polymorphisms (SNPs) within some these multiple stepwise regression analysis including other independent predictors (IL28B(rs12979860), serum 25OH-vitamin D, alfa-fetoprotein (AFP)) were performed on a...
Flavonoids possess different interesting biological properties, including antibacterial, antiviral, anti-inflammatory and antioxidant activities. However, unfortunately, these molecules present bottlenecks, such as low aqueous solubility, photo oxidative degradability, high first-pass effect, poor intestinal absorption and, hence, systemic bioavailability. A variety of delivery systems have been developed to circumvent drawbacks, among them, in this work niosomes selected encapsulate the...
Ferroptosis is a non-apoptotic form of cell death resulting from the iron-dependent accumulation lipid peroxides. Colorectal cancer (CRC) cells accumulate high levels intracellular iron and reactive oxygen species (ROS) are thus particularly sensitive to ferroptosis. The compound (S)-RSL3 ([1S,3R]-RSL3) commonly used ferroptosis inducing that currently characterized as selective inhibitor selenocysteine containing enzyme (selenoprotein) Gluathione Peroxidase 4 (GPx4), an utilizes glutathione...
The use of doxorubicin (DOX) to treat various tumors is limited by its cardiotoxicity. This study aimed investigate and compare the cardioprotective effects nicotinamide (NAM) alfacalcidol (1α(OH)D3), against DOX-induced Sprague Dawley male rats received DOX (5 mg/kg, i.p.) once/week for four consecutive weeks. Treated groups either NAM (600 p.o.) 28 days or 1α(OH)D3 (0.5 ug/kg, elicited marked cardiac tissue injury manifested elevated serum cardiotoxicity indices, conduction...
With the rising incidence of hepatocellular carcinoma (HCC) from non-alcoholic steatohepatitis (NASH), identifying new metabolic readouts that function in pathway perpetuation is still a demand. The study aimed to compare signature between NASH and NASH-HCC patients explore novel reprogrammed pathways might modulate cancer progression patients. were recruited screened for metabolomics, isotope-labeled lipidomics targeted profiled using EXION-LCTM system equipped with Triple-TOFTM 5600+...
The present study aims to formulate and evaluate the efficacy of chrysin-loaded nanoemulsion (CH NE) against lithium/pilocarpine-induced epilepsy in rats, as well as, elucidate its effect on main pathogenesis cornerstones; neuronal hyperactivity, oxidative stress, neuroinflammation.NEs were characterized by droplet size, zeta potential, pH, vitro release, accelerated long-term stability studies. Anti-convulsant optimized formula underlying mechanisms involved assessed compared that from CH...
Abstract Background Doxorubicin (DOX), a widely used chemotherapeutic agent, can cause neurodegeneration in the brain, which leads to condition known as chemobrain. In fact, chemobrain is deteriorating adversely affects lives of cancer survivors. This study aimed examine potential therapeutic effects bone marrow mesenchymal stem cells (BMSCs) and their derived exosomes (BMSCs-Exo) DOX-induced rat models. Methods Chemobrain was induced by exposing rats DOX (2 mg/kg, i.p) once weekly for 4...
non-alcoholic steatohepatitis (NASH) recently headlined hepatocellular carcinoma (HCC) worldwide. This study aims to unveil the role of some unaddressed critical players that might aid in understanding, predicting, and targeting NASH NASH-HCC.Serum interleukin 13 (IL-13) levels single nucleotide polymorphisms (SNPs) within (IL)-13 rs20541, IL-13 receptors (IL-13R1) rs2248841, (IL-13R2) rs5946040, signal transducer activator transcription 6 (STAT6) rs167769, yes-associated protein (YAP1)...
End-stage liver disease is marked by portal hypertension, systemic elevations in ammonia, and development of hepatocellular carcinoma (HCC). While these clinical consequences cirrhosis are well described, it remains poorly understood whether hepatic insufficiency the accompanying ammonia contribute to HCC carcinogenesis. Using preclinical models, we discovered that entered cell through transporter SLC4A11 served as a nitrogen source for amino acid nucleotide biosynthesis. Elevated promoted...
Abstract We sought in our cross-sectional study to investigate the role of metabolic/hypoxial axis development tamoxifen (TMX) resistance BC patients. Quantification plasma LncRNA Taurine upregulated-1 (TUG-1), miRNA 186-5p (miR-186), serum Sirtuin-3 (SIRT3), Peroxisome Proliferator Activator Receptor alpha (PPAR-1 α) and Hypoxia Inducible Factor-1 (HIF-1α) was done a cohort patients divided into TMX-sensitive TMX-resistant candidates. Multiple logistic regression Receiver Operating...
Cardiovascular-disease (CVD)-related mortality has been fueled by the upsurge of non-alcoholic steatohepatitis (NASH). Mesenchymal stem cells (MSCs) were extensively studied for their reparative power in ameliorating different CVDs via direct and paracrine effects. Several reports pointed to importance bone marrow mesenchymal (BM-MSCs) as a reliable therapeutic approach several CVDs. Nevertheless, potential not yet investigated cardiotoxic state that is induced NASH. Thus, this study sought...
Abstract Non-alcoholic fatty liver (NAFLD) is a widespread disease with various complications including steatohepatitis (NASH) that could lead to cirrhosis and ultimately hepatocellular carcinoma (HCC). Up till now there no FDA approved drug for treatment of NAFLD. Flavonoids such as Rhamnetin (Rhm) have been ascribed effective anti-inflammatory anti-oxidative properties. Thus, Rhm potent flavonoid target multiple pathological cascades causing NAFLD prevent its progression into HCC....