A5044469435- Cancer, Hypoxia, and Metabolism
- Hemoglobinopathies and Related Disorders
- Ferroptosis and cancer prognosis
- Eicosanoids and Hypertension Pharmacology
- Erythrocyte Function and Pathophysiology
- Autophagy in Disease and Therapy
- Iron Metabolism and Disorders
- Immune cells in cancer
- Complement system in diseases
- SMEs Development and Digital Marketing
- RNA modifications and cancer
- MicroRNA in disease regulation
- Sulfur Compounds in Biology
- Metabolism, Diabetes, and Cancer
- Blood groups and transfusion
- COVID-19 Pandemic Impacts
- Metabolomics and Mass Spectrometry Studies
- Cancer-related Molecular Pathways
- FinTech, Crowdfunding, Digital Finance
- High Altitude and Hypoxia
- Fibroblast Growth Factor Research
- Cutaneous lymphoproliferative disorders research
- Stock Market Forecasting Methods
- Epigenetics and DNA Methylation
- Trace Elements in Health
University of Michigan
2019-2024
Michigan United
2023
Noida International University
2016-2021
Laboratoire d’immunologie intégrative du cancer
2021
Regional Centre for Biotechnology
2014-2019
Sparrow Hospital
2018
Manipal Academy of Higher Education
2016
University of Pittsburgh Medical Center
2012-2014
UPMC Presbyterian
2012
University College of Medical Sciences
2011
Abstract Thrombocytopenia is common in patients with dengue virus (DENV) infections. With a focus on understanding the possible mechanism of thrombocytopenia DENV infections we described direct correlation between activation and depletion platelets patients. Our data showed sharp decrease platelet counts at day 4 fever The high genome copies correlated directly elevated along increased binding complement factor C3 IgG their surface 4. Recovery count was observed 10 through 6 8 simultaneous...
Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis confers resistance to chemo radiotherapies. Hypoxic responses are largely mediated by the transcription factors hypoxia-inducible factor 1α (HIF-1α) HIF-2α. Our work demonstrates HIF-2α essential for colorectal cancer (CRC) progression. However, targeting hypoxic cells difficult, rapidly acquire inhibitors To overcome this limitation, we performed small molecule screen identify HIF-2α-dependent...
Mitophagy is a cargo-specific autophagic process that recycles damaged mitochondria to promote mitochondrial turnover. PTEN-induced putative kinase 1 (PINK1) mediates the canonical mitophagic pathway. However, role of PINK1 in diseases where mitophagy has been purported play role, such as colorectal cancer, unclear. Our results here demonstrate higher expression positively correlated with decreased colon cancer survival, and required for growth. We show doxycycline-inducible knockdown (KD)...
BRAF mutations are highly specific for papillary thyroid carcinoma (PTC) and many cytology specimens with expected to demonstrate cytologic features typical of PTC. However, indeterminate cases inevitable understanding the significance mutation within context Bethesda System Reporting Thyroid Cytopathology would be valuable.Thyroid submitted conventional cytomorphologic evaluation mutational analyses were selected from authors' cytopathology files April 2007 October 2011. From this group,...
Cancer cells reprogram cellular metabolism to maintain adequate nutrient pools sustain proliferation. Moreover, autophagy is a regulated mechanism break down dysfunctional components and recycle nutrients. However, the requirement for integration in cancer cell not clear colon cancer. Here, we show cell-autonomous dependency of growth colorectal Loss epithelial inhibits tumor both sporadic colitis-associated models. Genetic pharmacological inhibition cancer–derived lines patient-derived...
The host-microbiome interface is rich in metabolite exchanges and exquisitely sensitive to diet. Hydrogen sulfide (H2S) present at high concentrations this interface, a product of both microbial host metabolism. mitochondrial enzyme, quinone oxidoreductase (SQOR), couples H2S detoxification oxidative phosphorylation; its inherited deficiency presents as Leigh disease. Since an estimated two thirds systemic metabolism originates gut, it raises questions whether impaired clearance compartment...
Abstract Hypoxic stress in solid tumors promotes cancer cell growth and survival confers therapeutic resistance. Hypoxia inducible factors (HIFs) are transcription that help cells adapt to hypoxic stress. HIFs often overexpressed associated with worse clinical outcomes. HIF inhibition is a novel strategy belzutifan first-in-class HIF-2α inhibitor. Belzutifan has recently been approved for metastatic renal carcinoma treatment. However, despite studies showing critical regulator of colorectal...
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Intravascular hemolysis increases the risk of thrombosis in hemolytic disorders. Our previous study showed that binding adult hemoglobin (HbA) to glycoprotein (GP) 1bα induced activation platelets. The elevated plasma Hb or platelet surface bound positively correlated with patients paroxysmal nocturnal hemoglobinuria (PNH). Furthermore, this shows sickle [HbS, occurs due single nucleotide polymorphism at A>T β-globin gene and causes cell disease (SCD)] also GP1bα activated platelets a...
Abstract The distinct response shown by different phenotypes of macrophages and monocytes under various clinical conditions has put the heterogeneity these cells into focus investigation for several diseases. Recently, we have described that after engulfing hemoglobin (Hb)‐activated platelets, classical differentiated pro‐inflammatory phenotypes, which were abundant in circulation paroxysmal nocturnal hemoglobinuria (PNH) sickle cell disease patients. Our current study shows upon engulfment...
Reports including our own describe that intravascular hemolysis increases the risk of thrombosis in hemolytic disorders. Our recent study shows plasma Hb concentrations correlate directly with platelet activation patients paroxysmal nocturnal hemoglobinuria (PNH). The binding to glycoprotein1bα (GP1bα) activation. A peptide AA1-50, designed from N-terminal amino acid sequence GP1bα significantly inhibits as well Hb-induced This further examined if Hb-mediated plays any significant role...
Herpes simplex virus type 1 encephalitis presents acutely in patients who are immunocompetent. We report what we believe to be the first published case of a subacute course herpes patient with asymptomatic chronic lymphocytic leukemia subsequently developed multiple sclerosis. A 49-year-old Caucasian woman history fever blisters presented emergency department left temporal headache for four weeks, and numbness face leg two weeks. complete blood count revealed white cell 11,820 cells/mL, an...
Diabetic lipemia, although common in type 2 diabetes, is rare 1 diabetes mellitus. It may manifest as lipemia retinalis, eruptive xanthomas, fatty liver, and pancreatitis. We describe a 6-year-old girl diagnosed with autoimmune poly-glandular syndrome IIIa, who presented diabetic manifesting xanthomas. Probable metabolic derangements causing such severe lipid abnormalities its treatment are discussed.
Abstract Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in US. Hypoxia a hallmark solid tumors which promotes tumor cell growth, survival, metastasis and confers resistance to chemo radiotherapies. Targeting hypoxic cells has been difficult. Moreover, inhibitors for major transcription factors, hypoxia inducible factor (HIF)-1α HIF-2α have not shown long-term efficacy most cancers. We previously that essential colon tumorigenesis. Using an unbiased screen, we...
Key Clinical Message Blastic plasmacytoid dendritic cell neoplasm is an aggressive with a median survival of only few months despite treatment. An exhaustive immunohistochemical workup required to differentiate it from myeloid sarcoma and extranodal NK /T lymphoma. Treatment induction using regimen utilized for leukemia. Allogeneic hematopoietic stem transplantation recommended those who achieve remission following induction.
Marketers have been using electronic tools for manyyears, but the internet and other information technologiescreated a flood of interesting innovative ways to providecustomer value. The more Internet settles into mainstreambusiness, it spawns innovation change.Electronic marketing is youngest membership growthdevices has grown tremendously since mainstreaming littlemore than two decades ago. E-marketing traditional marketingusing technology with some twists. Themarketing transformation...
In a recent work, we have described the kinetics among monocyte subsets in peripheral blood of hemolytic patients including paroxysmal nocturnal hemoglobinuria (PNH) and sickle cell disease (SCD). After engulfing Hb-activated platelets, classical monocytes (CD14+CD16-) significantly transformed into highly inflammatory (CD14+CD16hi) vitro. An estimated 40% total circulating PNH 70% SCD existed as CD14+CD16hi subsets. this study, show that nonclassical (CD14dimCD16+) are nearly absent with or...