A5011519619- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Folate and B Vitamins Research
- Epigenetics and DNA Methylation
- Autophagy in Disease and Therapy
- Blind Source Separation Techniques
- Image and Signal Denoising Methods
- Intracerebral and Subarachnoid Hemorrhage Research
- Endoplasmic Reticulum Stress and Disease
- Metabolomics and Mass Spectrometry Studies
- Advanced Data Compression Techniques
- Cancer Research and Treatments
University of Michigan–Ann Arbor
2022-2024
Laboratoire d’immunologie intégrative du cancer
2018-2021
Iron-related disorders are among the most prevalent diseases worldwide. Systemic iron homeostasis requires hepcidin, a liver-derived hormone that controls mobilization through its molecular target ferroportin (FPN), only known mammalian exporter. This pathway is perturbed in cause overload. Additionally, intestinal HIF-2α essential for local absorptive response to systemic deficiency and Our data demonstrate hetero-tissue crosstalk mechanism, whereby hepatic hepcidin regulated deficiency,...
Cancer cells reprogram cellular metabolism to maintain adequate nutrient pools sustain proliferation. Moreover, autophagy is a regulated mechanism break down dysfunctional components and recycle nutrients. However, the requirement for integration in cancer cell not clear colon cancer. Here, we show cell-autonomous dependency of growth colorectal Loss epithelial inhibits tumor both sporadic colitis-associated models. Genetic pharmacological inhibition cancer–derived lines patient-derived...
For image compression, it is very necessary that the selection of transform should reduce size resultant data as compared to original set. In this paper, a new lossless compression method proposed. continuous and discrete time cases, wavelet packet has emerged popular techniques. While integer using lifting scheme significantly reduces computation time, we propose completely approach for further speeding up computation. First, (WPT) (LS) are described. Then an application LS WPT presented...
Abstract Classic hereditary hemochromatosis (HH) is an autosomal recessive iron-overload disorder resulting from loss-of-function mutations of the HFE gene. Patients with HH exhibit excessive hepatic iron accumulation that predisposes these patients to liver disease, including risk for developing cancer. Chronic overload also poses a development metabolic disorders such as obesity, type 2 diabetes, and insulin resistance. We hypothesized liraglutide, GLP1 receptor agonist, alters metabolism...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer that highly malignant and lethal. The treatment options are limited, contributing to its high mortality rate. PDAC known have profound metabolic alterations enable growth survival. Here, we screened for amino acid dependency in cell lines found the cells cluster into cysteine dependent, moderately independent cells. In dependent cells, deprivation reduces viability by ∼90%, which could be rescued glutathione (GSH)...