A5090530567- Lung Cancer Diagnosis and Treatment
- AI in cancer detection
- Salivary Gland Tumors Diagnosis and Treatment
- Cervical Cancer and HPV Research
- Lung Cancer Treatments and Mutations
- Medical Imaging and Pathology Studies
- Pancreatic and Hepatic Oncology Research
- Radiology practices and education
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Thyroid Cancer Diagnosis and Treatment
- Tumors and Oncological Cases
- Head and Neck Anomalies
- Tracheal and airway disorders
- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Global Cancer Incidence and Screening
- Viral-associated cancers and disorders
- Lymphadenopathy Diagnosis and Analysis
- Head and Neck Cancer Studies
- Colorectal Cancer Screening and Detection
- Advances in Oncology and Radiotherapy
- Infectious Diseases and Mycology
- Breast Lesions and Carcinomas
Geisinger Medical Center
2021-2025
European Molecular Biology Organization
2024
The University of Texas MD Anderson Cancer Center
2019-2024
Università Cattolica del Sacro Cuore
2017-2024
Massachusetts General Hospital
2015-2024
Beth Israel Deaconess Medical Center
2023-2024
Faculty of Media
2023
University of Parma
2022
nView Medical (United States)
2022
Children's Hospital of Pittsburgh
2012-2022
Objective DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the evaluation cysts (PCs). Mutations in KRAS / GNAS are highly specific for intraductal papillary mucinous neoplasms (IPMNs) and cystic (MCNs), while TP53 PIK3CA PTEN alterations associated with advanced neoplasia. A prospective study was performed evaluate preoperative PCF DNA testing. Design Over 43-months, 626 specimens from 595 patients were obtained by endoscopic ultrasound (EUS)-fine needle aspiration...
Background & AimsNext-generation sequencing (NGS) of pancreatic cyst fluid is a useful adjunct in the assessment patients with cyst. However, previous studies have been retrospective or single institutional experiences. The aim this study was to prospectively evaluate NGS on multi-institutional cohort real time.MethodsThe performance 22-gene panel (PancreaSeq) first retrospectively confirmed and then within 2-year timeframe, PancreaSeq testing used endoscopic ultrasound–guided fine-needle...
The Bethesda System for Reporting Thyroid Cytopathology is largely based on data from adult studies. Although thyroid nodules in children are rare, the rate of malignancy high. authors' aim was to analyze cytomorphology and mutational profiles pediatric fine-needle aspirations (FNAs).Thyroid FNAs patients 21 years old or younger were identified pathology archive, categorized using Cytopathology, correlated with histological molecular follow-up.A total 179 samples 142 identified, including 96...
Objective Despite improvements in imaging, serum CA19-9 and pathological evaluation, differentiating between benign malignant bile duct strictures remains a diagnostic conundrum. Recent developments next-generation sequencing (NGS) have opened new opportunities for early detection management of cancers but, to date, not been rigorously applied biliary specimens. Design We prospectively evaluated 28-gene NGS panel (BiliSeq) using endoscopic retrograde cholangiopancreatography-obtained...
Background: In the recent past, algorithms and recommendations to standardize morphological, immunohistochemical molecular classification of lung cancers on cytology specimens have been proposed, several organizations recommended cell blocks (CBs) as preferred modality for testing. Based literature, there are different techniques available CB preparation-suggesting that is no standard. The aim this study was conduct a survey preparation utilized in various practice settings analyze current...
The evaluation of lymph nodes (LN) by fine-needle aspiration cytology (FNAC) is routinely used in many institutions but it not uniformly accepted mainly because the lack guidelines and a cytopathological diagnostic classification. A committee cytopathologists has developed system performance, classification, reporting for LN-FNAC.The members prepared document that circulated among them five times; final text been approved all participants. It based on review international literature...
Peer review is an important part of the scientific process, but traditional peer at journals coming under increased scrutiny for its inefficiency and lack transparency. As preprints become more widely used accepted, they raise possibility rethinking peer-review process. Preprints are enabling new forms that have potential to be thorough, inclusive, collegial than journal review, thus fundamentally shift culture toward constructive collaboration. In this Consensus View, we make a call action...
Two promising ancillary tests used in the diagnosis of mesothelioma include GLUT-1 immunohistochemical analysis and fluorescence situ hybridization (FISH) testing for p16 deletion. This study compared diagnostic usefulness FISH mesothelial proliferations 158 cases with a benign (45.4%), atypical (10.4%), or malignant/mesothelioma (44.2%). Of 70 cases, none had deletion 5 (7%) were positive GLUT-1. 68 mesotheliomas, 40 (59%) (sensitivity, 59%; specificity, 100%) 27 (40%) 40%; 93%). showed...
The aim of this study was to test the hypothesis that our 60-gene DNA/RNA ThyroSeq v2 next-generation sequence (NGS) assay would identify additional genetic markers, including gene fusions in sporadic pediatric differentiated thyroid carcinomas (DTC) had no known molecular alterations. Sporadic DTCs with informative testing ( n = 18) were studied. We previously tested 15 cases by standard 7-gene BRAF, NRAS, HRAS, KRAS, RET/PTC1, RET/PTC3, PAX8/PPARg) mutation panel. Three not previously....
Background: Digital slides obtained from whole slide imaging (WSI) platforms are typically viewed in two dimensions using desktop personal computer monitors or more recently on mobile devices. To the best of our knowledge, we not aware any studies viewing digital pathology a virtual reality (VR) environment. VR technology enables users to be artificially immersed and interact with computer-simulated world. Oculus Rift is among world's first consumer-targeted headsets, intended primarily for...
BACKGROUND Whole‐slide imaging in cytology is limited when glass slides are digitized without z‐stacks for focusing. Different vendors have started to provide z‐stacking solutions overcome this limitation. The Panoptiq system allows users create digital files combining low‐magnification panoramic images with regions of interest (ROIs) that imaged high‐magnification z‐stacks. aim study was compare such conventional whole‐slide and the tasks screening interpretation cytopathology. METHODS...
ATF5, a transcription factor important in differentiation, proliferation and survival, has been found to be highly expressed neural progenitor cells certain tumors including glioblastomas (GBMs), but its expression other normal neoplastic tissues not extensively investigated. A tissue microarray immunostained for ATF5 showed diffuse nuclear (as defined by the presence greater than 25% of cells) 63% (117/186) samples, when compared only 32% (20/62) nonneoplastic tissues. When analyzed...
Abstract BACKGROUND: Fine‐needle aspiration (FNA) cytology is increasingly being used as a diagnostic modality for soft tissue and bone lesions. These diagnoses can be challenging because of variety factors, including interpretation sampling issues. This study investigates the utility FNA biopsy, in addition to pitfalls, cytopathology. METHODS: We retrospectively reviewed FNAs over 4‐year period (2004‐2008), along with available ancillary studies, pathological follow‐up, clinical data. The...
The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) provides a reporting scheme thyroid fine needle aspiration (FNA) and includes three indeterminate categories with different management strategies. This study analyzes FNAs in children, correlates these findings the histological features.A total of 179 FNA specimens were retrieved from children. Cases categorized by TBSRTC. Only cases diagnosed as atypia (AUS)/follicular lesion undetermined significance (FLUS), suspicious...
BACKGROUND Endobronchial ultrasound‐guided fine‐needle aspiration (EBUS‐FNA) is a minimally invasive modality for diagnosing mediastinal lesions. When determining adequacy, EBUS‐FNAs are evaluated diagnostic material or sufficient lymphoid tissue. In this study, the authors their experience with and correlated findings adequacy histologic follow‐up. METHODS were retrospectively reviewed over 3‐year period clinicopathologic findings, RESULTS total, 593 obtained from 356 patients, including...
Salivary gland aspiration cytology is useful in the preoperative management of patients but remains challenging, because extensive morphologic overlap some tumors limits ability to always determine presence malignancy. In response this challenge, there has been increasing drive develop a risk-based categorization scheme for salivary aspirates. Herein, authors examine interobserver variability 1 such pattern and system.Select smears cell-block sections 50 aspirates from 2 large academic...
Preprints enable new forms of peer review that have the potential to be more thorough, inclusive, and collegial. In December 2022, 80 researchers representatives funders, institutions, preprint servers, journals, indexers, services were invited gather online at Janelia Research Campus for a workshop on Recognizing Preprint Peer Review. Sponsored by HHMI, ASAPbio, EMBO, this meeting aimed catalyze community consensus support create model funder, institutional, journal policies recognize both...
Abstract Background There is increasing interest in designing new fine‐needle aspiration (FNA) needles to maximize tissue acquisition. This study compares cytological preparations from a rotating FNA needle (CytoCore) with conventional (ConvFNA) using semiquantitative evaluation and quantitative image analysis (IA). Methods were performed on ex vivo quadruplicate for each type (ConvFNA CytoCore), including different sizes (22 G 25 G) variable procedure time (5 20 s). The Nikon Elements...
Background: One of the novel techniques utilizing fine needle aspiration (FNA) in diagnosis mediastinal and lung lesions is endobronchial ultrasound (EBUS)-guided FNA. In this study, we describe five cases which had a discrepancy between on-site evaluation final diagnosis, or diagnostic dilemma when rendering preliminary order to illustrate some difficulties pitfalls that can occur EBUS Methods: A total FNA from patients were identified our records with rapid (ROSE) addressed dilemma. All...
The significance of histologic subtyping surgically resected lung adenocarcinoma (ADC) was recently proposed by the International Association for Study Lung Cancer/American Thoracic Society/European Respiratory Society (IASLC/ATS/ERS) classification. Approximately 70% cancer patients present with advanced disease, and small biopsies or cytology specimens are frequently only available diagnostic material. It is uncertain whether morphologic ADC can be applied to specimens. objective this...