A5051902236- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Gastric Cancer Management and Outcomes
- Transplantation: Methods and Outcomes
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- IgG4-Related and Inflammatory Diseases
- Liver Disease Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Esophageal Cancer Research and Treatment
- Lung Cancer Research Studies
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Neuroblastoma Research and Treatments
- Colorectal Cancer Screening and Detection
- Xenotransplantation and immune response
- Renal cell carcinoma treatment
- Colorectal Cancer Treatments and Studies
- T-cell and B-cell Immunology
- Renal Transplantation Outcomes and Treatments
- Helicobacter pylori-related gastroenterology studies
- Occupational and environmental lung diseases
Emory University
2014-2024
Emory University Hospital
2004-2024
Massachusetts General Hospital
2021
Harvard University
2021
Memorial Sloan Kettering Cancer Center
2020
Palmetto Hematology Oncology
2019
Winship Cancer Institute
2016-2018
Yale University
2018
National Taiwan University Hospital
2018
University of Pittsburgh
2007-2017
Rates of colon cancer are much higher in African Americans (65:100,000) than rural South Africans (<5:100,000). The rates associated with animal protein and fat, lower fibre consumption, colonic secondary bile acids, short-chain fatty acid quantities mucosal proliferative biomarkers risk otherwise healthy middle-aged volunteers. Here we investigate further the role fat this association. We performed 2-week food exchanges subjects from same populations, where were fed a high-fibre, low-fat...
International experts met to discuss recent advances and revise the 2004 recommendations for assessing reporting precursor lesions invasive carcinomas of pancreas, including pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm (IPMN), cystic neoplasm, other lesions. Consensus include following: (1) To improve concordance align with practical consequences, a 2-tiered system (low vs. high grade) is proposed all lesions, provision that current PanIN-2 neoplasms...
The 2010 World Health Organization (WHO) classification recommends that pancreatic neuroendocrine tumors (PanNETs) be graded on the basis of mitotic rate and Ki67 index, with grade 2 (G2) PanNETs defined as having a to 20 figures/10 high-power fields or index 3% 20%. Grade 3 (G3) carcinoma (NEC) is >20 >20%. However, some show discordance between usually in G3 range but suggesting G2, prompting us examine clinical significance large series clinically well-characterized G2 PanNETs. Mitotic...
In Brief Objective: To evaluate the effects of surgical weight loss on fatty liver disease in severely obese patients. Summary Background Data: Nonalcoholic (NAFLD), a spectrum that extends to fibrosis and cirrhosis, is rising at an alarming rate. This increase occurring conjunction with rise severe obesity probably mediated part by metabolic syndrome (MS). Surgical operations, reversing MS, have been shown result improvement histology. Methods: Patients who underwent laparoscopic operations...
OBJECTIVES: Autoimmune pancreatitis (AIP) is increasingly recognized as a form of chronic pancreatitis. Systematic evaluation and management AIP in the United States reported only from one center. Our aim was to review at large tertiary METHODS: We retrospectively reviewed information on demographics, clinical presentation, laboratory imaging findings, extrapancreatic involvement, treatment response, recurrence 26 patients with treated University Pittsburgh Medical Center 1998 2007. RESULTS:...
There are no established guidelines for pathologic diagnosis/reporting of intraductal papillary mucinous neoplasms (IPMNs).
In the pancreas, poorly differentiated neuroendocrine carcinomas include small cell carcinoma and large are rare; data regarding their pathologic clinical features very limited.
Abstract Background Trials examining FOLFIRINOX in metastatic pancreatic cancer demonstrate higher response rates compared to gemcitabine‐based regimens. There is currently limited experience with neoadjuvant cancer. Methods Retrospective review of outcomes patients borderline resectable or locally unresectable who were recommended undergo treatment FOLFIRINOX. Results was for 25 cancer, 13 (52%) and 12 (48%) resectable. Four (16%) refused lost follow‐up. Twenty‐one (84%) treated a median...
Intrahepatic noncirrhotic portal hypertension can be idiopathic or associated with known toxic, developmental, vascular, biliary tract diseases. Most patients are successfully managed medically shunting procedures. The goal of this study was to explore the reasons some require orthotopic liver transplantation (OLT). clinical features, gross and microscopic explant pathology, posttransplantation course in 16 who underwent OLT for intrahepatic were studied. There 11 men 5 women a mean age 47...
The epidermal growth factor receptor (EGFR) and its downstream signaling pathways are involved in the development progression of several human tumors, including colorectal cancer. Much attention has been given to EGFR pathway as lately because both some components serve targets for anticancer therapy. In addition playing a critical role targeted therapy, alterations this can have prognostic implications. impact on carcinogenesis prognosis emphasis paper. Since is tightly related response...
Ampullary (AMP) carcinomas comprise a heterogeneous group of cancers lacking adequate subcategorization. In the present study, 249 strictly defined primary AMP (ACs) identified in 1469 malignant pancreatoduodenectomy specimens were analyzed for defining features. Gross and microscopic findings used to determine tumor epicenter extent preinvasive component. ACs classified into 4 distinct subtypes based on location: (1) Intra-AMP (25%): Invasive arising intra-ampullary papillary-tubular...
Pancreatic cancer is an almost uniformly lethal disease, characterized by late diagnosis, early metastasis, resistance to chemotherapy, and mutation of the Kras oncogene. Here we show that receptor for advanced glycation endproducts (RAGE) required activation interleukin 6 (IL-6)-mediated mitochondrial signal transducers activators transcription 3 (STAT3) signaling in pancreatic carcinogenesis. RAGE expression correlates with elevated levels autophagy vivo vitro, this heightened state...
<h3>Importance</h3>Multicenter studies indicate that outcomes of open (ODP) and minimally invasive distal pancreatectomy (MIDP) are equivalent for benign lesions. However, data pancreatic carcinoma limited.<h3>Objective</h3>To compare ODP MIDP early-stage ductal to determine relative safety oncologic efficacy.<h3>Design</h3>Retrospective analysis 62 consecutive patients undergoing or by intention treat with propensity scoring correct selection bias.<h3>Setting</h3>A high-volume university...
Undifferentiated carcinomas with osteoclastic giant cells of the pancreas (OGC) are rare tumors. The current impression in literature is that they highly aggressive tumors similar prognosis to ductal adenocarcinomas. In this study, clinicopathologic characteristics 38 resected OGCs were investigated and contrasted 725 pancreatic adenocarcinomas without (PDCs). frequency among systematically reviewed cancers was 1.4%. showed a slight female predominance (62.9%, vs. 51.4% PDCs). mean age 57.9...
Gastrointestinal stromal tumors (GISTs) are the most common nonepithelial neoplasm of gastrointestinal tract and show a predilection for stomach. Most detected because symptoms, but some incidental findings at autopsy or surgery other reasons. Incidental GISTs tend to be smaller diagnosis, even small (<1 cm) have been shown harbor activating KIT mutations rates similar advanced GISTs. However, prevalence characteristics in surgical resections esophagogastric junction (EGJ) remains unclear....