A5042273117- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Genetic factors in colorectal cancer
- Lung Cancer Research Studies
- Gastrointestinal Tumor Research and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Disease Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Epigenetics and DNA Methylation
- Uterine Myomas and Treatments
- Adrenal and Paraganglionic Tumors
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Neuroblastoma Research and Treatments
- Genetic Syndromes and Imprinting
- Biliary and Gastrointestinal Fistulas
- Thyroid Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- IgG4-Related and Inflammatory Diseases
- Pituitary Gland Disorders and Treatments
- Soft tissue tumor case studies
Marmara University
2015-2025
Koç University
2022
University of Alabama at Birmingham
2022
University of Michigan
2022
Tata Memorial Hospital
2020
Université de Sherbrooke
2020
Emory University
2011-2017
Samsung Medical Center
2015
Sungkyunkwan University
2015
University of Ulsan
2015
The literature on the clinicopathologic characteristics of tumoral intraepithelial neoplasms (neoplastic polyps) gallbladder (GB) is fairly limited, due in part to variability definition and terminology. Most reported adenomas (pyloric gland type others) were microscopic thus regarded as clinically inconsequential, whereas papillary situ carcinomas have been largely considered a invasive adenocarcinoma under heading "papillary adenocarcinomas." In this study, 123 GB cases that well-defined...
The interaction between tumor cells and inflammatory has an important role in cancer initiation progression; however, this not been systematically investigated pancreatic neoplasia. In study, the presence of tumor-infiltrating neutrophils within and/or adjacent to neoplastic was neoplasms. Areas with >10 neutrophils/100 epithelial were arbitrarily classified as positive. Those 11–15 considered 'borderline' while those >15 'significant'. Among 363 invasive ductal carcinomas, 15 showed...
Ampullary (AMP) carcinomas comprise a heterogeneous group of cancers lacking adequate subcategorization. In the present study, 249 strictly defined primary AMP (ACs) identified in 1469 malignant pancreatoduodenectomy specimens were analyzed for defining features. Gross and microscopic findings used to determine tumor epicenter extent preinvasive component. ACs classified into 4 distinct subtypes based on location: (1) Intra-AMP (25%): Invasive arising intra-ampullary papillary-tubular...
Information on the clinicopathologic characteristics of invasive carcinomas arising from mucinous cystic neoplasms (MCNs) is limited, because in many early studies they were lumped and analyzed together with noninvasive MCNs. Even more importantly, largest prior did not require ovarian-type stroma (OTS) for diagnosis. We 178 MCNs, all strictly defined by presence OTS, 98% which occurred perimenopausal women (mean age, 47 y) arose distal pancreas. Twenty-nine (16%) patients had associated...
Undifferentiated carcinomas with osteoclastic giant cells of the pancreas (OGC) are rare tumors. The current impression in literature is that they highly aggressive tumors similar prognosis to ductal adenocarcinomas. In this study, clinicopathologic characteristics 38 resected OGCs were investigated and contrasted 725 pancreatic adenocarcinomas without (PDCs). frequency among systematically reviewed cancers was 1.4%. showed a slight female predominance (62.9%, vs. 51.4% PDCs). mean age 57.9...
Pancreaticoduodenectomy (PD) specimens present a challenge for surgical pathologists because of the relative rarity these specimens, combined with anatomic complexity. Here, we describe our experience on orientation, dissection, and sampling PD more practical accurate evaluation pancreatic, distal common bile duct (CBD), ampullary tumors. For orientation PDs, identification "trapezoid," created by vascular bed at center, pancreatic neck margin left, uncinate right, is outmost importance in...
There are virtually no data in the literature regarding incidence, patterns, and clinicopathologic characteristics of mucinous carcinomas (MCs) gallbladder (GB).To determine incidence differentiation invasive GB those that qualify as MC.Primary (n = 606) were reviewed for differentiation. Some degree mucin production was identified 40 cases (6.6%); however, only 15 (2.5%) qualified World Health Organization definition MC (stromal deposition constituting >50% tumor).The mean age 65 years,...
Background Different perspectives exist regarding the clinicopathologic characteristics, biology and management of gallbladder polyps. Size is often used as surrogate evidence polyp behavior size ≥1cm widely cholecystectomy indication. Most studies on this issue are based pathologic correlation polyps clinically selected for resection, whereas, data nature polypoid lesions from pathology perspective -regardless indication- highly limited. Methods In study, 4231 gallbladders -606 which had...
Objective. The presence of high tumor budding in colorectal carcinomas is a significant pathological feature indicative potential for lymph node metastasis. Our aim was to investigate the prognostic impact ampullary carcinomas. Materials and methods. We conducted cohort 101 consecutive carcinoma resections evaluate budding, macroscopic microscopic subtypes, lymphatic/vascular/perineural invasions, other histopathological parameters. Results. High observed 49 (49%) tumors, multivariate...
Objective: Preoperative identification of familial pheochromocytoma and paraganglioma (PPGL) is crucial, yet often overlooked, leading to missed diagnoses. Typically, succinate dehydrogenase-B (SDHB) fumarate hydratase (FH) tests are applied postoperatively confirm links assess prognosis. However, routine preoperative multidisciplinary collaboration limited, causing delayed screening requests. Consequently, SDHB FH immunohistochemistry (IHC) testing not widely practiced. This study...
Massive gastric polyposis is a rare entity that often associated with juvenile syndrome (JPS). The aim of this study was to evaluate the clinicopathological features 22 patients abundant juvenile-type or hyperplastic-like polyps.The included 12 males and 10 females median age 48 years (range: 13-79 years). Fourteen (64%) carried diagnosis JPS, three had prior gastrointestinal adenocarcinomas. Patients without known JPS presented at an older (60 versus 40 years; P = 0.0068). Clinical symptoms...
Tumoral (grossly visible) intraductal neoplasms of the bile ducts are still being characterized.To investigate their morphologic, immunohistochemical, and molecular features.Forty-one cases were classified as gastric-, intestinal-, pancreatobiliary-type papillary neoplasm (IPN), oncocytic (IOPN), or tubulopapillary (ITPN) on basis histology. All subjected to targeted next-generation sequencing.The mean age at diagnosis was 69 years (42-81 years); male female ratio 1.3. Most (n = 23, 56%)...