Donald W. Weaver
A5036134584- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Acute Myocardial Infarction Research
- Immunotherapy and Immune Responses
- Geology and Paleoclimatology Research
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Colorectal Cancer Surgical Treatments
- RNA modifications and cancer
- Cardiac Imaging and Diagnostics
- Cardiac, Anesthesia and Surgical Outcomes
- Stellar, planetary, and galactic studies
- Coronary Interventions and Diagnostics
- Cancer Research and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Genetic factors in colorectal cancer
- Botany and Geology in Latin America and Caribbean
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Cardiac Arrest and Resuscitation
- Virus-based gene therapy research
- Archaeology and Natural History
- CAR-T cell therapy research
- Anorectal Disease Treatments and Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Neuroendocrine Tumor Research Advances
Wayne State University
2014-2023
Detroit Medical Center
2003-2022
John D. Dingell VA Medical Center
2011-2020
Sylvester Comprehensive Cancer Center
2019
University of Miami
2019
Beth Israel Deaconess Medical Center
2017
Roswell Park Comprehensive Cancer Center
2017
NorthShore University HealthSystem
2017
Cedars-Sinai Medical Center
2017
The University of Texas MD Anderson Cancer Center
2017
In the past, colloid (mucinous noncystic) carcinoma (CC) of pancreas had been included under category ordinary ductal adenocarcinoma, a tumor with dismal prognosis, or was frequently misdiagnosed as mucinous cystadenocarcinoma. The clinicopathologic features CC have not yet well characterized, because most cases on record parts studies either cystic neoplasms (MCN) intraductal papillary (IPMN), which carcinomas are associated. To determine characteristics CC, 17 pancreatic tumors composed...
The authorship of the report "The Modulation Fluorouracil With Leucovorin in Metastatic Colorectal Carcinoma: A Randomized Phase III Trial," published October 1989 issue (J Clin Oncol 7:1419–1426, 1989) should have read: "by Gastrointestinal Tumor Study Group." following appendix also appeared at end report:
Poly-sulfobetaine surface modification on a vascular catheter inhibits microbial adherence and thrombosis.
Pancreaticoduodenectomy (PD) specimens present a challenge for surgical pathologists because of the relative rarity these specimens, combined with anatomic complexity. Here, we describe our experience on orientation, dissection, and sampling PD more practical accurate evaluation pancreatic, distal common bile duct (CBD), ampullary tumors. For orientation PDs, identification "trapezoid," created by vascular bed at center, pancreatic neck margin left, uncinate right, is outmost importance in...
Pancreatic carcinoma is considered among the most chemoresistant of human malignancies. The commonly used cytotoxic single agents, 5-fluorouracil and 2'-deoxy-2',2'-difluorocytidine (gemcitabine), have objective response rates less than 10% in large studies. Hypothesizing noncross resistance a synergistic interaction between gemcitabine cisplatin, early clinical studies demonstrated significant activity with this combination patients several types malignant disease. A Phase II study was...
• The effect of albumin when added to the resuscitation regimen patients in hypovolemic shock was studied a randomized prospective manner 52 injured who received an average 15.3 transfusions, 9.6 liters balanced electrolyte solution, and 980 ml fresh frozen plasma. Before during operation, 27 25 gm 150 gm/day for three five days. Patients had greater dependence on respiratory support, averaging eight days while receiving ventilatory support with volume ventilator compared not albumin....
Albumin, when added to a standard resuscitation regimen, is purported enhance plasma volume, improve pulmonary function by its oncotic effect, and prevent renal failure augmenting salt water excreation. These factors were evaluated in prospective randomized manner 52 injured patients who received an average of 15.3 transfusions, 9.6 L balanced electrolyte solution, 9.8 fresh frozen prior during operation; 27 25 gm albumin (Alb) operation 150 gm/day for 3 days thereafter. Alb caused...
To determine the frequency of c-Kit staining in desmoids and optimize an assay for clinical use, we stained 19 from various sites at dilutions with 2 commonly used rabbit polyclonal, anti-c-Kit antibodies (A4502, DAKO, Carpinteria, CA; C-19, Santa Cruz Biotechnology, Cruz, CA), without heat-induced epitope retrieval (HIER) citrate buffer. Appropriate external internal control samples were evaluated each test condition. At 1:50 both substantial numbers desmoids: with/without HIER, A4502,...
Ovarian cancer is the leading cause of mortality from gynecological malignancies, often undetectable in early stages. The difficulty detecting disease its stages and propensity ovarian cells to develop resistance known chemotherapeutic treatments dramatically decreases 5-year survival rate. Chemotherapy with paclitaxel after surgery increases median only by 2 3 years stage IV highlights need for more effective drugs. human immunodeficiency virus (HIV) infection characterized increased risk...
The incidence of Barrett esophageal adenocarcinoma (BEAC) has been increasing at an alarming rate in western countries. In this study, we have evaluated the therapeutic potential sulforaphane (SFN), antioxidant derived from broccoli, BEAC.BEAC cells were treated with SFN, alone or combination chemotherapeutic, paclitaxel, telomerase-inhibiting agents (MST-312, GRN163L), and live cell number determined various time points. effect on drug resistance/chemosensitivity was by rhodamine efflux...
Abstract Background Sulforaphane (SFN), an isothiocyanate phytochemical present predominantly in cruciferous vegetables such as brussels sprout and broccoli, is considered a promising chemo-preventive agent against cancer. In-vitro exposure to SFN appears result the induction of apoptosis cell-cycle arrest variety tumor types. However, molecular mechanisms leading inhibition cell cycle progression by are poorly understood epithelial ovarian cancer cells (EOC). The aim this study understand...
The effects of albumin supplementation on pulmonary function were studied in 94 injured patients whom 46 received albumin. an average 14.5 transfusions, 9.2 L crystalloid, and 0.9 plasma the emergency room operating room; 31 gm during operation 150 gm/day for 5 days. Blood pressure (BP), pulse, CVP, wedge (PWP), red cell (RBCV), volumes (PV), total serum proteins (TSP), (SA), cardiac output (CO), per cent inspired oxygen/arterial O2 tension (FIO2/pO2), physiologic shunting lungs (p shunt)...
Megacam is a large-format optical camera that can be operated at the f/5 Cassegrain foci of MMT on Mount Hopkins, Arizona, and Magellan Clay telescope Las Campanas Observatory, Chile. Megacam's focal plane composed 36 closely packed e2v CCD42-90 CCDs, each with 2048 × 4608 pixels, assembled in an 18,432 array. Two additional CCD42-90s are provided for autoguiding focus control. The CCDs have 13.5 μm square pixels subtend foci, yielding 25' field-of-view. system includes shutter, two filter...
We evaluated the ability of fenoldopam, a newly available renal vasodilator, to prevent radiocontrast nephropathy in high-risk patients undergoing interventional diagnostic and therapeutic angiographic procedures. reviewed results from 46 consecutive procedures with serum creatinine > or = 1.5 mg/dL if diabetic 1.7 nondiabetic. compared our previously published cohort similarly at-risk patients. The incidence nephropathy, defined as an increase 25% at 48 hr following procedure, was 13% group...