A5046422945- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Adipose Tissue and Metabolism
- Circular RNAs in diseases
- Coronary Interventions and Diagnostics
- Cardiac tumors and thrombi
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Myocardial Infarction Research
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Wound Healing and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Mesenchymal stem cell research
- Cardiovascular Disease and Adiposity
- Radiology practices and education
- Atrial Fibrillation Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Adipokines, Inflammation, and Metabolic Diseases
- Venous Thromboembolism Diagnosis and Management
- Sarcoidosis and Beryllium Toxicity Research
- Vascular Procedures and Complications
- Biomedical and Engineering Education
- Pancreatic and Hepatic Oncology Research
- Diagnosis and Treatment of Venous Diseases
- Health and Medical Research Impacts
New York Hospital Queens
2021-2022
NewYork–Presbyterian Hospital
2021-2022
Columbia University
2021-2022
Presbyterian Hospital
2022
Harvard University
2016-2021
Brigham and Women's Hospital
2016-2021
Columbia University Irving Medical Center
2021
Hacettepe University
2019-2020
Yale University
2019
Yale New Haven Hospital
2018-2019
Pancreaticoduodenectomy (PD) specimens present a challenge for surgical pathologists because of the relative rarity these specimens, combined with anatomic complexity. Here, we describe our experience on orientation, dissection, and sampling PD more practical accurate evaluation pancreatic, distal common bile duct (CBD), ampullary tumors. For orientation PDs, identification "trapezoid," created by vascular bed at center, pancreatic neck margin left, uncinate right, is outmost importance in...
Objective- In response to tissue injury, the appropriate progression of events in angiogenesis is controlled by a careful balance between pro and antiangiogenic factors. We aimed identify characterize microRNAs that regulate injury. Approach Results- show microRNA-615-5p (miR-615-5p) rapidly induced serves as an microRNA targeting endothelial cell VEGF (vascular growth factor)-AKT (protein kinase B)/eNOS (endothelial nitric oxide synthase) signaling vitro vivo. MiR-615-5p expression...
Angiogenesis is a critical process in repair of tissue injury that regulated by delicate balance between pro- and antiangiogenic factors. In disease states associated with impaired angiogenesis, we identified miR-135a-3p rapidly induced serves as an microRNA (miRNA) targeting endothelial cell (EC) p38 signaling vitro vivo. MiR-135a-3p overexpression significantly inhibited EC proliferation, migration, network tube formation matrigel, whereas miR-135-3p neutralization had the opposite...
Neoangiogenesis is critical for tissue repair in response to injury such as myocardial ischemia or dermal wound healing. MicroRNAs are small noncoding RNAs and important regulators of angiogenesis under physiological pathological disease states. Therefore, identification microRNAs that may restore impaired provide new targets therapy. Using a microRNA microarray profiling approach, we identified human-specific microRNA, miR-4674, was significantly decreased patients after had an endothelial...
Endocardial Fibroelastosis is diffuse, accentuated proliferation of ventricular endocardium causing a rare form restrictive cardiomyopathy in both children and adults. It an incompletely understood cause heart failure predominantly Sub-Saharan Africa associated with high morbidity mortality. Atrial fibrillation thrombus formation are common accompanying complications portend poor prognosis. Due to rarity the condition developed countries lack evidence based options, optimal strategy for...
White and brown adipose tissues are highly vascularized organs, capable of plasticity based on metabolic demands energy expenditure, which if maladaptive can lead to insulin resistance. Critical gaps remain in our understanding how angiogenesis impacts tissue dysfunction overall metabolism. MicroRNAs (miRs) implicated the regulation angiogenic response pathophysiological stimuli. Function miRNAs regulating diet-induced resistance remains poorly understood. Using a miRNA-Seq approach, we...
Brown adipose tissue (BAT), a highly vascularized, thermogenic tissue, converts chemical energy into heat. The ability of BAT to expand based on the metabolic demand, known as plasticity, plays critical role in regulation whole body balance. Endothelial cells (ECs) within microvasculature play an important aiding retain plasticity by actively modulating angiogenic response. However, mechanism EC-adipocyte cross-talk during this process is not completely understood. In ECs obese mice, we have...
Gogia, Shawnbir; Edens, Madison; Fall, Khady N.; Petrossian, Gregory; Horst, Jennifer; Jas Garcia, Javier; Ozdemir, Denizhan; Karimi Galougahi, Keyvan; Karmpaliotis, Dimitri; Kirtane, Ajay J.; Ben-Yehuda, Ori; Maehara, Akiko; Mintz, Gary S.; Ali, Ziad A. Author Information