A5040654673- DNA Repair Mechanisms
- Telomeres, Telomerase, and Senescence
- Cancer therapeutics and mechanisms
- Multiple Myeloma Research and Treatments
- Cancer Genomics and Diagnostics
- CRISPR and Genetic Engineering
- Helicobacter pylori-related gastroenterology studies
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Oral Health Pathology and Treatment
- SARS-CoV-2 and COVID-19 Research
- Polyomavirus and related diseases
- Genomics, phytochemicals, and oxidative stress
- Respiratory viral infections research
- Cancer Research and Treatments
- HIV/AIDS drug development and treatment
- Head and Neck Cancer Studies
- Chromosomal and Genetic Variations
- Adipose Tissue and Metabolism
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- PARP inhibition in cancer therapy
- Ubiquitin and proteasome pathways
- Cancer-related Molecular Pathways
- Synthesis and biological activity
Pt. Jawahar Lal Nehru Memorial Medical College
2017-2024
Dana-Farber Cancer Institute
2009-2023
VA Boston Healthcare System
2010-2014
Harvard University
2009-2014
Jawaharlal Nehru University
2014
Jagannath University
2011
Wayne State University
2009-2010
Ovarian cancer is the leading cause of mortality from gynecological malignancies, often undetectable in early stages. The difficulty detecting disease its stages and propensity ovarian cells to develop resistance known chemotherapeutic treatments dramatically decreases 5-year survival rate. Chemotherapy with paclitaxel after surgery increases median only by 2 3 years stage IV highlights need for more effective drugs. human immunodeficiency virus (HIV) infection characterized increased risk...
The incidence of Barrett esophageal adenocarcinoma (BEAC) has been increasing at an alarming rate in western countries. In this study, we have evaluated the therapeutic potential sulforaphane (SFN), antioxidant derived from broccoli, BEAC.BEAC cells were treated with SFN, alone or combination chemotherapeutic, paclitaxel, telomerase-inhibiting agents (MST-312, GRN163L), and live cell number determined various time points. effect on drug resistance/chemosensitivity was by rhodamine efflux...
Abstract Background Sulforaphane (SFN), an isothiocyanate phytochemical present predominantly in cruciferous vegetables such as brussels sprout and broccoli, is considered a promising chemo-preventive agent against cancer. In-vitro exposure to SFN appears result the induction of apoptosis cell-cycle arrest variety tumor types. However, molecular mechanisms leading inhibition cell cycle progression by are poorly understood epithelial ovarian cancer cells (EOC). The aim this study understand...
We have previously reported that homologous recombination (HR) is dysregulated in multiple myeloma (MM) and contributes to genomic instability development of drug resistance. now demonstrate base excision repair (BER) associated apurinic/apyrimidinic (AP) nucleases (APEX1 APEX2) contribute regulation HR MM cells. Transgenic as well chemical inhibition APEX1 and/or APEX2 inhibits activity cells, whereas the overexpression either nuclease normal human increases activity. Regulation by AP could...
The purpose of this study was to identify drivers genomic evolution in esophageal adenocarcinoma (EAC) and other solid tumors.
Potential of nonantibiotic therapies for treatment Helicobacter pylori-related acid peptic disease remains underexplored. Several clinical studies have shown that higher prevalence H. pylori infection is associated with low Vitamin C (Vit C) level in serum and gastric juice. However, there no consensus regarding the usefulness Vit supplementation management infection. Surveying existing literature we conclude high concentration juice might inactivate urease, key enzyme pathogen's survival...
Unpredictable fatal outcome of COVID-19 is attributed to dysregulated inflammation. Impaired early adaptive immune response leads late-stage inflammatory outcome. The purpose this study was develop biomarkers for detection host impairment at first diagnosis from leftover RNA samples, which may in turn identify high risk patients. Leftover samples patients were stored. Following prospective follow-up, the shorted and categorized into groups. T cell (severity score) IL-10 (undetectable...
In normal cells, RAD51-mediated homologous recombination (HR) is a precise DNA repair mechanism which plays key role in the maintenance of genomic integrity and stability. However, elevated (dysregulated) RAD51 implicated instability potential target for treatment certain cancers, including Barrett's adenocarcinoma (BAC). this study, we investigated impact translational significance moderate vs. strong suppression BAC cells.BAC cells (FLO-1 OE33) were transduced with non-targeting control...
Oral squamous cell carcinoma (OSCC) is often preceded by a white patch on surface of the mouth, called oral leukoplakia (OL). As accelerated telomere length (TL) shortening in dividing epithelial cells may lead to oncogenic transformation, measurement could serve as predictive biomarker OL. However, due high variability and lack universal reference, there has been limited translational application. Here, we describe an approach evaluating TL using paired peripheral blood mononuclear (PBMC)...
Gram-negative bacteria Helicobacter pylori cause gastric ulcer, duodenal cancer, and found in almost half of the world's residents. The protein responsible for this disease is secreted through type IV secretion system (TFSS) H. pylori. TFSS encoded by 40-kb region chromosomal DNA known as cag-pathogenicity island (PAI). comprises three major components: cytoplasmic/inner membrane ATPase, transmembrane core-complex outer membranous pilli, associated subunits. Core complex consists CagX, CagT,...
<title>Abstract</title> Unpredictable fatal outcome of COVID-19 is attributed to dysregulated inflammation. Impaired early adaptive immune response leads late stage inflammatory outcome. The purpose this study was develop biomarkers for detection host impairment at first diagnosis from leftover RNA samples, which may in turn identify high risk patients. Leftover samples patients were stored. Following prospective follow-up, the shorted and categorized into groups. T cell (severity score)...
Background: Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine condition that affects women of reproductive age, often associated with obesity and insulin resistance. Of particular concern the association between PCOS obesity, which exacerbates metabolic dysfunction, resistance, risk developing Type 2 diabetes cardiovascular disease. Irisin, novel myokine, has garnered significant interest for its potential role in energy metabolism glucose homeostasis regulation....