A5101601015- RNA modifications and cancer
- RNA Research and Splicing
- Multiple Myeloma Research and Treatments
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Immune Cell Function and Interaction
- Beetle Biology and Toxicology Studies
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Bioinformatics and Genomic Networks
- Immunotherapy and Immune Responses
- Cardiac Imaging and Diagnostics
- Cancer therapeutics and mechanisms
- Lung Cancer Treatments and Mutations
- RNA and protein synthesis mechanisms
- Genetic factors in colorectal cancer
University of Virginia
2022
Medical University of South Carolina
2012-2015
Kent State University
2012-2015
Dana-Farber Cancer Institute
2013
Harvard University
2013
MUSC Hollings Cancer Center
2012
A major challenge in the clinical management of human cancers is to accurately stratify patients according risk and likelihood a favorable response. Stratification confounded by significant phenotypic heterogeneity some tumor types, often without obvious criteria for subdivision. Despite intensive transcriptional array analyses, identity validation cancer specific 'signature genes' remains elusive, partially because transcriptome does not mirror proteome. The simplification associated with...
Understanding intrinsic and acquired resistance is crucial to overcoming cancer chemotherapy failure. While it well-established that intratumor, subclonal genetic phenotypic heterogeneity significantly contribute resistance, not fully understood how tumor sub-clones interact with each other withstand therapy pressure. Here, we report a previously unrecognized behavior in heterogeneous tumors: cooperative adaptation (CAT), which cells induce co-resistant phenotypes neighboring when exposed...
Abstract Drug-induced resistance, or tolerance, is an emerging yet poorly understood failure of anticancer therapy. The interplay between drug-tolerant cancer cells and innate immunity within the tumor, consequence on tumor growth, therapeutic strategies to address these challenges remain undescribed. Here, we elucidate role taxane-induced resistance natural killer (NK) cell in triple-negative breast (TNBC) design spatiotemporally controlled nanomedicines, which boost efficacy invigorate...
RNA and its associated binding proteins (RBPs) mitigate a diverse array of cellular functions phenotypes. The interactions between RBPs are implicated in many roles biochemical processing by the cell such as localization, protein translation, stability. Recent discoveries novel mechanisms that significant evolutionary advantage include interaction RBP with 3' 5' untranslated region (UTR) target mRNA. These shown to function through trans-factor (RBP) cis-regulatory element (3' or UTR)...