A5002913296- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Lung Cancer Treatments and Mutations
- Nonmelanoma Skin Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Gastrointestinal Tumor Research and Treatment
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- Gastrointestinal disorders and treatments
- Liver Disease Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Liver Disease and Transplantation
- Cutaneous Melanoma Detection and Management
- Drug Transport and Resistance Mechanisms
- Developmental Biology and Gene Regulation
- Renal cell carcinoma treatment
- Barrier Structure and Function Studies
- Esophageal and GI Pathology
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Celiac Disease Research and Management
Massachusetts General Hospital
2018-2024
Harvard University
2020-2024
Boston University
2024
University of Pittsburgh Medical Center
2023
Brigham and Women's Hospital
2023
Massachusetts Institute of Technology
2023
Radiation Oncology Associates
2021
University of Pennsylvania
1983-2018
Hospital of the University of Pennsylvania
2014-2018
Pontificia Universidad Javeriana
2016
The KRAS oncogene is a driver mutation and present in greater than 90% of pancreatic ductal adenocarcinomas (PDAC). A subset these tumors, however, do not harbor mutations (wild type KRAS). Studies have shown that patients with mutated poorer survival on first-line gemcitabine-based chemotherapy compared to wild KRAS. In this study, we examined cohort PDAC at our institution who were either or mutant for the gene assessed differences response different chemotherapeutic regimens.We clinical...
Altered host-microbe interactions and increased intestinal permeability have been implicated in disease pathogenesis. However, the mechanisms by which microbes affect epithelial barrier integrity remain unclear. Here, we investigate impact of bacterial metabolism host-produced bile acid (BA) metabolites on integrity. We observe that rats fed a choline-deficient, l -amino acid–defined, high-fat diet (CDAHFD) exhibit reduced abundance conjugated BAs at early time points, coinciding with gut...
Massive gastric polyposis is a rare entity that often associated with juvenile syndrome (JPS). The aim of this study was to evaluate the clinicopathological features 22 patients abundant juvenile-type or hyperplastic-like polyps.The included 12 males and 10 females median age 48 years (range: 13-79 years). Fourteen (64%) carried diagnosis JPS, three had prior gastrointestinal adenocarcinomas. Patients without known JPS presented at an older (60 versus 40 years; P = 0.0068). Clinical symptoms...
Abstract Background Over 700 donor livers are discarded annually in the United States due to high risk of poor graft function. The objective this study was determine impact using normothermic machine perfusion identify transplantable among those currently discarded. Study Design A series 21 human underwent viability assessment during perfusion. Cross‐sectional analysis Scientific Registry Transplant Recipients database and cost performed extrapolate case national experience. Results were...
Evidence suggests that early-onset gastric cancers are distinct from traditional cancers; however, detailed genomic and morphologic characterization of these has not been performed.Genomic analysis was performed for 81 patients with cancer who were 50 years old or younger; pathology slides available 53 patients, they re-reviewed to perform a morphologic-molecular correlation analysis. The results compared corresponding cBioPortal data Cancer Genome Atlas (TCGA) analysis, which represent...
Abstract Lipophilic but not hydrophilic statins have been shown to be associated with reduced risk for hepatocellular carcinoma (HCC) in patients chronic viral hepatitis. We investigated differential actions of lipophilic and their ability modulate a clinical prognostic liver signature (PLS) predicting HCC disease. Hepatitis C virus (HCV)–infected Huh7.5.1 cells, recently developed as model screen chemopreventive agents, were treated (atorvastatin simvastatin) (rosuvastatin pravastatin),...
Abstract Purpose: Perineural invasion (PNI) is associated with aggressive tumor behavior, recurrence, and metastasis, can influence the administration of adjuvant treatment. However, standard histopathologic examination has limited sensitivity in detecting PNI does not provide insights into its mechanistic underpinnings. Experimental Design: A multivariate Cox regression was performed to validate associations between survival 2,029 patients across 12 cancer types. Differential expression...
This is the case of an 84-year-old woman diagnosed with Stage IVb colon adenocarcinoma (CRC) metastatic to liver, retroperitoneum, anastomotic site, and distal rectal sigmoid colon. She experienced intolerable side effects systemic chemotherapy 5-fluorouracil bevacizumab, as well disease progression. Next generation sequencing her tumor was ordered, further discussion malignancy's genomic information took place at a multidisciplinary molecular board. The patient had mutations in KRAS...
Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare disease characterized by intimal smooth muscle proliferation, leading to thickening small medium-sized veins. This vascular mimics inflammatory bowel (IBD) clinically and endoscopically, while showing ischemic mucosal changes without classic features IBD on biopsy. Given mixed picture, this entity frequently misdiagnosed. Surgical resection diseased segment reveals true etiology pathology curative. We describe case...
Barrett's esophagus is a well-recognized risk factor for esophageal adenocarcinoma. The natural history of classified as 'indefinite dysplasia' (IND) poorly characterized. aim this study to characterize the IND by determining rate neoplastic progression and identifying factors progression. Patients from University Pennsylvania Health System pathology database registry with diagnosis between 2000 2014 were identified. Exclusion criteria included: (1) prior low-grade dysplasia (LGD),...
Context.—Phosphatase and tensin homolog (PTEN) is one of the most frequently inactivated tumor suppressor genes in sporadic cancers. Somatic mutations PTEN occur many tumors including those gastrointestinal hepatobiliary tracts. Loss expression associated with poor prognosis patients metastatic colonic adenocarcinoma, gastroesophageal junction gastric pancreatic ductal adenocarcinoma. Objective.—To study its significance ampullary adenocarcinoma (AA). Design.—We constructed tissue...