A5006528676- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Pancreatitis Pathology and Treatment
- Colorectal Cancer Surgical Treatments
- Neuroendocrine Tumor Research Advances
- Colorectal and Anal Carcinomas
- IgG4-Related and Inflammatory Diseases
- Immunotherapy and Immune Responses
- Immune cells in cancer
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Pediatric Hepatobiliary Diseases and Treatments
- Chronic Lymphocytic Leukemia Research
- Acute Myeloid Leukemia Research
- Thyroid Cancer Diagnosis and Treatment
- Advanced biosensing and bioanalysis techniques
- Minimally Invasive Surgical Techniques
- Microscopic Colitis
- Head and Neck Surgical Oncology
- Adrenal and Paraganglionic Tumors
Beth Israel Deaconess Medical Center
2023-2024
International Association for the Study of Lung Cancer
2023
Boston University
2020-2023
Lahey Medical Center
2023
Boston Medical Center
2021-2023
Harvard University
2023
University Medical Center
2022
Massachusetts General Hospital
2016-2021
University of Michigan
2005-2020
Tufts Medical Center
2015-2018
Recent randomized control trials (JCOG0802 and CALGB140503) have shown sublobar resection to be noninferior lobectomy for non-small cell lung cancer (NSCLC) ≤2.0 cm. We previously proposed histologic criteria stratifying adenocarcinoma into indolent low malignant potential (LMP) aggressive angioinvasive adenocarcinomas, resulting in better prognostication than provided by World Health Organization grade. Here we determine whether pathologic classification is reproducible subsets of...
Lung cancer screening has improved mortality among high-risk smokers but coincidentally detected a fraction of nonprogressive adenocarcinoma historically classified as bronchoalveolar carcinoma (BAC). In the National Screening Trial (NLST) majority BAC—comprising 29% computed tomography–detected stage I lung adenocarcinoma—were considered overdiagnosis after extended follow-up comparison with control arm. current classification, in situ and minimally invasive have replaced BAC together...
Background: A subset of encapsulated/circumscribed follicular variant papillary thyroid carcinoma (FVPTC) was reclassified as noninvasive neoplasm with papillary-like nuclear features (NIFTP) in 2016 to reduce overtreatment a low-risk tumor. Study objectives were describe the epidemiology and long-term outcomes NIFTP high-volume, urban, tertiary referral center. Methods: Among patients enrolled Boston Medical Center (BMC) Thyroid Cancer Registry, 110 cases FVPTC underwent index surgery at...
Inflammatory pseudotumor is a term used to designate inflammation-rich tumefactive lesions. Following the exclusion of specific entities such as IgG4-related disease and other neoplastic previously included in this entity, majority hepatic pseudotumors show prominent fibrohistiocytic inflammatory reaction have been categorized variant (FHVHPT). The goal study was examine clinical, radiologic, histologic, etiologic aspects entity. After excluding diseases, we identified 30 patients with...
Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring response. While proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity these applications. Long INterspersed Element-1 (LINE-1, L1) open reading frame 1 protein (ORF1p) is a transposable element overexpressed in carcinomas high-risk precursors during carcinogenesis with negligible detectable expression corresponding normal tissues,...
Aims Venous invasion (VI) in colorectal carcinoma influences treatment strategies, especially early stages. Despite elastin staining effectiveness detecting VI, guidelines for its routine application, including the optimal number of slides staining, are limited. Methods Elastin was performed VI assessment patients with adenocarcinoma. Patients were categorised into two groups: single stain group (SEG, n=248) and multiple (MEG, n=204). Results The average elastin-stained blocks 2±1.7,...
This report describes a case of primary hepatic diffuse large B-cell lymphoma (DLBCL) in 64-year-old male who presented with constitutional symptoms, jaundice, abdominal swelling, and right upper quadrant pain. The diagnosis was confirmed on percutaneous liver biopsy. Notably, there no evidence extra-hepatic involvement. patient received methylprednisolone cyclophosphamide good response but lost to follow-up upon being transferred. highlights the importance considering DLBCL patients...
Micropapillary carcinoma (MPC) is a recognised WHO variant of colonic (CC), although little known about its prognosis, immune microenvironment and molecular alterations. We investigated clinical, pathological immunological characteristics.
Serrated adenocarcinoma (SAC), a recognised WHO variant of colonic adenocarcinoma, is the purported end-product serrated neoplasia. However, diagnosis SAC infrequently rendered, and little known about its prognosis, immune microenvironment molecular alterations.We assessed 903 consecutive colon carcinomas tumours with ≥ 5% (n = 77) 50% patterns 13). We precursor polyps synchronous polyps. recorded demographic/clinical parameters, histological features mismatch repair (MMR) status. performed...
The pancreatobiliary tract exhibits a spectrum of heterogeneous fibroinflammatory conditions that may be the result primary immune-mediated mechanism, or reaction to neoplasm. This often results in significant overlap regarding clinical presentation, symptoms, radiographic findings, serology, and histopathology between inflammatory neoplastic lesions pancreas, which can lead inadvertent surgical intervention. Among multitude pancreatic diseases, autoimmune pancreatitis, including type 1 2...
Adrenal - renal fusion is a rare entity defined as incomplete encapsulation of the adrenal gland and kidney with histologically adjacent functional tissue. This report describes first published intraoperative identification this anomaly during laparoscopic adrenalectomy. The patient was 59-year-old man chronic hypertension refractory to multiple antihypertensives found be caused by right-sided aldosterone-producing adenoma in setting bilateral hyperplasia. During adrenalectomy, normal...
There is an unmet need for identifying novel biomarkers in Barrett's esophagus that could stratify patients with regards to neoplastic progression. We investigate the expression patterns of extracellular matrix (ECM) molecules and esophagus-related neoplasia, assess their value as diagnosis neoplasia predict Gene-expression analyses ECM matrisome gene sets were performed using publicly available data on human esophagus, dysplasia, esophageal adenocarcinoma (ADCA) normal esophagus....
Aims The lack of accepted scoring criteria has precluded the use p53 in routine practice. We evaluate utility automated quantitative analysis risk stratifying Barrett’s oesophagus (BE) patients using non-dysplastic BE (NDBE) biopsies a multicentric cohort progressor (P) and non-progressor (NP) patients. Methods NDBE prior to diagnosis advanced neoplasia from 75 BE-P, index last surveillance 148 BE-NP were stained for p53, scored digitally as 1+, 2+ 3+. A secondary 30 BE-P was evaluated....
The potent immunostimulatory effects of toll-like receptor 8 (TLR8) agonism in combination with PD-1 blockade have resulted various preclinical investigations, yet the mechanism action humans remains unknown. To decipher combinatory mode TLR8 and blockade, we employed a unique, open-label, phase 1b pre-operative window opportunity clinical trial (NCT03906526) head neck squamous cell carcinoma (HNSCC) patients. Matched pre- post-treatment tumor biopsies from same lesion were obtained. We used...
The potent immunostimulatory effects of toll-like receptor 8 (TLR8) agonism in combination with PD-1 blockade have resulted various preclinical investigations, yet the mechanism action humans remains unknown. To decipher combinatory mode TLR8 and blockade, we employed a unique, open-label, phase 1b pre-operative window opportunity clinical trial (NCT03906526) head neck squamous cell carcinoma (HNSCC) patients. Matched pre- post-treatment tumor biopsies from same lesion were obtained. We used...