A5015976844- Lung Cancer Diagnosis and Treatment
- Occupational and environmental lung diseases
- Cancer Research and Treatments
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Esophageal Cancer Research and Treatment
- Medical Imaging and Pathology Studies
- Esophageal and GI Pathology
- Gastric Cancer Management and Outcomes
- Cancer Cells and Metastasis
- Lung Cancer Treatments and Mutations
- Surgical Simulation and Training
- Radiomics and Machine Learning in Medical Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Airway Management and Intubation Techniques
- Tissue Engineering and Regenerative Medicine
- Pneumothorax, Barotrauma, Emphysema
- Myasthenia Gravis and Thymoma
- Congenital Diaphragmatic Hernia Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac tumors and thrombi
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
Lahey Medical Center
2017-2025
Lahey Hospital and Medical Center
2017-2025
Tufts University
2020-2025
University of Massachusetts Chan Medical School
2024-2025
Beth Israel Deaconess Medical Center
2024-2025
Intuitive Surgical (Switzerland)
2025
Thoracic Surgery Foundation
2023
Society of Thoracic Surgeons
2020-2022
Brigham and Women's Hospital
2015
Harvard University
2015
Regional CAR T cell delivery provides superior protection compared to systemic administration.
The purpose of this study was to describe the frequency interventions necessary palliate intact primary tumor in patients who present with synchronous, stage IV colorectal cancer (CRC) and receive up-front modern combination chemotherapy without prophylactic surgery.
Abstract Purpose: Mesothelin (MSLN) is a tumor-associated antigen, being investigated as biomarker and therapeutic target in malignant pleural mesothelioma (MPM). The biologic function of MSLN overexpression MPM unknown. We hypothesized that may promote tumor invasion MPM, characterized primarily by regional aggressiveness rare distant metastases. Experimental Design: Human murine cells with forced expression short hairpin RNA knockdown were examined for proliferation, invasion, matrix...
In an effort to identify molecular markers of tumor aggressiveness and therapeutic targets in lung adenocarcinoma (ADC), we investigated the expression mesothelin (MSLN) ADC, as well its biologic clinical relevance.In a training validation set patients with early-stage (I-III) ADC (n = 1,209), tissue microarray consisting tumors normal was used examine association between MSLN recurrence-free survival (RFS) overall (OS). The influence overexpression on vitro vivo by use clinically relevant...
Objective: To evaluate demographics and quality metrics across racial ethnic groups amongst patients undergoing lung resection for non-small cell cancer (NSCLC) within the Society of Thoracic Surgeons General Surgery Database (STS GTSD). Summary Background: Studies evaluating disparities NSCLC are limited. Methods: A retrospective cohort analysis STS GTSD was performed between 2015-2022. Multivariable logistic regression operation (wedge versus anatomic resection), operative approach (open...
Abstract Background: Mesothelin is overexpressed in several malignancies and purportedly a specific marker of malignant transformation. In this pilot study, we investigated whether tissue serum mesothelin are potential markers neoplastic progression Barrett's esophagus (BE) esophageal adenocarcinoma (EAC). Methods: expression was retrospectively evaluated normal, BE, EAC from surgically resected specimens (n = 125). addition, soluble mesothelin-related peptide (SMRP) levels were measured...
Recent randomized control trials (JCOG0802 and CALGB140503) have shown sublobar resection to be noninferior lobectomy for non-small cell lung cancer (NSCLC) ≤2.0 cm. We previously proposed histologic criteria stratifying adenocarcinoma into indolent low malignant potential (LMP) aggressive angioinvasive adenocarcinomas, resulting in better prognostication than provided by World Health Organization grade. Here we determine whether pathologic classification is reproducible subsets of...