A5036008725- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Medical Imaging and Pathology Studies
- Advanced X-ray and CT Imaging
- Pleural and Pulmonary Diseases
- Radiation Dose and Imaging
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Global Cancer Incidence and Screening
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Colorectal Cancer Screening and Detection
- Lung Cancer Research Studies
- Cardiovascular Disease and Adiposity
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Radiology practices and education
- Cancer Genomics and Diagnostics
- Digital Radiography and Breast Imaging
- Esophageal Cancer Research and Treatment
- Atomic and Subatomic Physics Research
- Tracheal and airway disorders
- Cardiovascular Function and Risk Factors
- Gastric Cancer Management and Outcomes
Icahn School of Medicine at Mount Sinai
2016-2025
Mount Sinai Health System
2015-2025
Cornell University
2003-2024
University of California, Irvine
2024
National Heart Lung and Blood Institute
2024
University of Louisville Hospital
2024
The University of Texas Health Science Center at Houston
2024
Mount Sinai Hospital
2014-2024
Harbin Medical University
2024
Third Affiliated Hospital of Harbin Medical University
2024
BackgroundThe Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low-radiation-dose computed tomography (low-dose CT) in people at high risk of lung cancer. We report the experience.MethodsELCAP has enrolled 1000 symptom-free volunteers, aged 60 years or older, with least 10 pack-years cigarette smoking no previous cancer, who were medically fit undergo thoracic surgery. After a structured interview informed consent, chest radiographs...
The outcome among patients with clinical stage I cancer that is detected on annual screening using spiral computed tomography (CT) unknown.In a large collaborative study, we screened 31,567 asymptomatic persons at risk for lung low-dose CT from 1993 through 2005, and 1994 27,456 repeated screenings were performed 7 to 18 months after the previous screening. We estimated 10-year lung-cancer-specific survival rate participants was diagnosed by biopsy, regardless of type treatment received,...
CT Screening for Lung CancerFrequency and Significance of Part-Solid Nonsolid NodulesClaudia I. Henschke1, David F. Yankelevitz1, Rosna Mirtcheva1, Georgeann McGuinness2, Dorothy McCauley1, Olli S. Miettinen3 the ELCAP GroupAudio Available | Share
PURPOSE: To determine the accuracy of high-resolution computed tomographic (CT) volumetric measurements small pulmonary nodules to assess growth and malignancy status. MATERIALS AND METHODS: The three-dimensional (3D) image extraction isotropic resampling techniques was assessed by performing three experiments. first experiment measured volumes in spherical synthetic two diameters (3.20 3.96 mm), second deformable silicone prior after their shape had been altered markedly, third various...
BACKGROUND The Early Lung Cancer Action Project (ELCAP) was designed to evaluate the usefulness of annual computed tomography (CT) screening for lung carcinoma. With baseline results having been reported previously, focus current study on early repeat screenings. METHODS A cohort 1000 high-risk individuals recruited and CT screening. At last follow-up, a total 1184 screenings had performed. positive result from test defined as newly detected, one six noncalcified pulmonary nodules with...
PURPOSE: To assess the frequency with which a particular, possibly optimal work-up of noncalcified nodules less than 5.0 mm in diameter identified on initial computed tomographic (CT) images at baseline screening leads to diagnosis malignancy prior first annual repeat screening, compared larger nodules. MATERIALS AND METHODS: Two series CT screenings high-risk people were retrospectively reviewed. The (n = 1,000) was performed 1993–1998; second 1,897), 1999–2002. In each series, cases...
To assess the usefulness of ordinal scoring visual assessment coronary artery calcification (CAC) on low-dose computed tomographic (CT) scans chest in prediction cardiovascular death.All participants consented to CT screening according an institutional review board-approved protocol. The amount CAC was assessed ungated obtained between June 2000 and December 2005 a cohort 8782 smokers aged 40-85 years. four main arteries were visually scored, each participant received score 0-12. date cause...
To address the frequency of identifying nonsolid nodules, diagnosing lung cancer manifesting as such and long-term outcome after treatment in a prospective cohort, International Early Lung Cancer Action Program.A total 57,496 participants underwent baseline subsequent annual repeat computed tomographic (CT) screenings according to an institutional review board, HIPAA-compliant protocol. Informed consent was obtained. The with course nodule at follow-up, resulting diagnoses cancer, treatment,...
Small pulmonary nodules are a common radiographic finding that presents an important diagnostic challenge in contemporary medicine. While the major indicator of lung cancer, they may also be signs variety benign conditions. Measurement nodule growth rate over time has been shown to most promising tool distinguishing malignant from nonmalignant nodules. In this paper, we describe three-dimensional (3-D) methods for segmentation, analysis, and characterization small imaged using computed...
Preclinical studies suggest that treatment with a selective cyclo-oxygenase-2 (COX-2) inhibitor may augment the antitumor effects of chemotherapy. In this study, patients non-small-cell lung cancer (NSCLC) were preoperatively treated celecoxib in combination End points toxicity, response rates, and measurement intratumoral levels prostaglandin E2 (PGE2).In phase II trial, 29 stages IB to IIIA NSCLC two preoperative cycles paclitaxel carboplatin, as well daily celecoxib, followed by surgical...
The pulmonary nodule is the most common manifestation of lung cancer, deadly all cancers. Most small nodules are benign, however, and currently growth rate provides for one accurate noninvasive methods determining malignancy. In this paper, we present measuring change in size from two computed tomography image scans recorded at different times; may be established. impact partial voxels evaluated isotropic resampling shown to improve measurement accuracy. Methods location sizing, pleural...
Does 2-year stability imply that pulmonary nodules are benign?D F Yankelevitz and C I HenschkeAudio Available | Share
PURPOSE: To determine reproducibility of volume measurements small pulmonary nodules on computed tomographic (CT) scans and to estimate critical time follow-up CT. MATERIALS AND METHODS: One hundred fifteen for which two thin-section small–field-of-view CT were obtained stable during 2-year observation evaluated. A standard group 94 (with no or minimal artifact) an expanded 105 (including those with moderate artifacts) examined. Percentage change (PVC) monthly volumetric growth index (MVGI)...
To empirically address the distribution of volume doubling time (VDT) lung cancers diagnosed in repeat annual rounds computed tomographic (CT) screening International Early Lung Cancer Action Program (I-ELCAP), first and foremost with respect to rates tumor growth but also terms cell types.All CT screenings I-ELCAP from 1993 2009 were performed according HIPAA-compliant protocols approved by institutional review boards collaborating institutions. All instances diagnosis primary cancer after...
Purpose To update information regarding the usefulness of computer-aided detection (CAD) systems with a focus on most critical category, that missed cancers at earlier imaging, for manifest as solid nodule. Materials and Methods By using HIPAA-compliant institutional review board–approved protocol where informed consent was obtained, 50 lung manifested nodule computed tomographic (CT) scans in annual rounds screening (time 1) were retrospectively identified could, retrospect, be previous CT...
Purpose Patients with early-stage, resectable, non–small-cell lung cancer (NSCLC) are at risk for recurrent disease, and 5-year survival rates do not exceed 75%. Angiogenesis inhibitors have shown clinical activity in patients late-stage NSCLC, raising the possibility that targeting vascular endothelial growth factor pathway earlier-stage disease may be beneficial. This proof-of-concept study examined safety efficacy of short-term, preoperative pazopanib monotherapy operable stage I/II...