Euihye Jung
A5078216652- Immunotherapy and Immune Responses
- vaccines and immunoinformatics approaches
- Viral-associated cancers and disorders
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- Studies on Chitinases and Chitosanases
- Cancer Genomics and Diagnostics
- Animal Virus Infections Studies
- Monoclonal and Polyclonal Antibodies Research
- Ovarian cancer diagnosis and treatment
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Molecular Biology Techniques and Applications
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- T-cell and Retrovirus Studies
- Parasites and Host Interactions
- Genetics, Aging, and Longevity in Model Organisms
- Immune cells in cancer
- Parasite Biology and Host Interactions
- Chemokine receptors and signaling
- Cell Adhesion Molecules Research
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Galectins and Cancer Biology
University of Pennsylvania
2007-2025
Cancer Research Center
2020-2025
The molecular and functional contributions of intratumoral nerves to disease remain largely unknown. We localized synaptic markers within tumors suggesting that these form connections. Consistent with this, electrophysiological analysis shows malignancies harbor significantly higher electrical activity than benign or normal tissues. also demonstrate pharmacologic silencing tumoral activity. Tumors implanted in transgenic animals lacking nociceptor neurons show reduced These data suggest at...
Over 200 million people have, and another 600 are at risk of contracting, schistosomiasis, one the major neglected tropical diseases. Transmission this infection, which is caused by helminth parasites genus Schistosoma, depends upon release parasite eggs from human host. However, approximately 50% produced schistosomes fail to reach external environment, but instead become trapped in host tissues where pathological changes immune responses secreted egg antigens precipitate disease. Despite...
Abstract Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring response. Although proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity these applications. Long INterspersed Element-1 (LINE-1) open reading frame 1 protein (ORF1p) is a transposable element overexpressed in carcinomas high-risk precursors during carcinogenesis with negligible expression normal tissues, suggesting ORF1p could...
Single-cell gene expression profiling provides unique opportunities to understand tumor heterogeneity and the microenvironment. Because of cost feasibility, bulk tumors remains primary population-scale analytical strategy. Many algorithms can deconvolve these using single-cell profiles infer their composition. While experimental choices do not change true underlying composition tumor, they affect measurements produced by assay.
Abstract Ovarian cancer is a leading cause of death for women worldwide, in part due to ineffective screening methods. In this study, we used whole-genome cell-free DNA (cfDNA) fragmentome and protein biomarker [cancer antigen 125 (CA-125) human epididymis 4 (HE4)] analyses evaluate 591 with ovarian cancer, benign adnexal masses, or without lesions. Using machine learning model the combined features, detected specificity >99% sensitivities 72%, 69%, 87%, 100% stages I IV,...
Help from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether helper polarization affects delivery help and/or responding helped by Th1 or Th2 express distinct effector properties. To address these issues, we compared responses in context injecting dendritic copulsed with major histocompatibility complex class I-restricted OVA peptide plus, respectively, bacterial helminth antigens. We found that cells,...
Unlike most pathogens, helminth parasites and their products induce strong Th2 responses, dendritic cells (DCs) macrophages exposed to antigens generally fail produce interleukin-12. Rather, it has been shown that such as soluble egg (SEA; a extract from Schistosoma mansoni eggs) inhibit the activation of DCs in response classical Toll-like receptor (TLR) ligands lipopolysaccharide or CpG. Nevertheless, recent work suggested TLR4 and/or TLR2 plays an important role recognition by development...
<p>Supplementary Figure S1. Evaluation of screening model DELFI-Pro scores and comorbidities in individuals without cancer. Supplementary S2. score evaluation available clinical characteristics patients with S3. Stability analysis across fold repeats collection source. S4. Detection ovarian cancer subtypes using model. S5. ROC analyses asymptomatic the or diagnostic models Discovery Cohort. S6. Performance ichorCNA median cfDNA fragment lengths Cohorts. S7. at high specificity. S8....
<div>Abstract<p>Ovarian cancer is a leading cause of death for women worldwide, in part due to ineffective screening methods. In this study, we used whole-genome cell-free DNA (cfDNA) fragmentome and protein biomarker [cancer antigen 125 (CA-125) human epididymis 4 (HE4)] analyses evaluate 591 with ovarian cancer, benign adnexal masses, or without lesions. Using machine learning model the combined features, detected specificity >99% sensitivities 72%, 69%, 87%, 100% stages I...
Long interspersed element 1 (LINE-1) retrotransposons are repetitive sequences that can move within the genome by an autonomous mechanism. To limit their mutagenic potential, benign cells restrict LINE-1 expression through molecular mechanisms such as DNA methylation and histone modification, but these usually impaired in cancer. Clear cell ovarian carcinoma (CCOC) represents 5-10% of cancers is thought to arise from endometriosis. Women with advanced CCOC face poor prognoses, highlighting...
Ovarian cancer (OC) is the most deadly gynecological malignancy, with unmet clinical need for new therapeutic approaches. The relaxin peptide a pleiotropic hormone reproductive functions in ovary. Relaxin induces cell growth several types of cancer, but role OC poorly understood. Here, using lines and xenograft models, we demonstrate that its associated GPCR RXFP1 form an autocrine signaling loop essential vivo tumorigenesis, proliferation, viability. We determined activates expression...
Abstract Background Single-cell gene expression profiling provides unique opportunities to understand tumor heterogeneity and the microenvironment. Because of cost feasibility, bulk tumors remains primary population-scale analytical strategy. Many algorithms can deconvolve these using single-cell profiles infer their composition. While experimental choices do not change true underlying composition tumor, they affect measurements produced by assay. Results We generated a dataset high-grade...
Improved biomarkers are needed for early cancer detection, risk stratification, treatment selection, and monitoring response. While proteins can be useful blood-based biomarkers, many have limited sensitivity or specificity these applications. Long INterspersed Element-1 (LINE-1, L1) open reading frame 1 protein (ORF1p) is a transposable element overexpressed in carcinomas high-risk precursors during carcinogenesis with negligible detectable expression corresponding normal tissues,...
High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this, we integrated high-plex imaging and spatial transcriptomics analyze human tissue samples at different stages of development, including p53 signatures, serous tubal intraepithelial carcinomas (STIC), invasive HGSOC. Our findings reveal immune modulating mechanisms within precursor...
Abstract High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this, we integrated high-plex imaging and spatial transcriptomics analyze human tissue samples at different stages of development, including p53 signatures, serous tubal intraepithelial carcinomas (STIC), invasive HGSOC. Our findings reveal immune modulating mechanisms within...
ABSTRACT Patients with densely innervated tumors do poorly as compared to those sparsely disease. Why some heavily recruit nerves while others not, remains unknown does the functional contribution of tumor-infiltrating cancer. Moreover, patients receive chemotherapeutic treatment, whether these drugs affect nerve recruitment has not been tested. Using a murine model ovarian cancer, we show that sensory potentiate tumor growth, decrease survival, and contribute treatment resistance....
Abstract Introduction: Ovarian cancer is the leading cause of death from gynecological related cancers worldwide. Most patients are diagnosed at late stages due to asymptomatic disease and lack effective screening modalities. Additionally, in women with an ovarian mass diagnosis can be challenging many having surgery only discover a benign pathology. Liquid biopsies, including analyses cell-free DNA (cfDNA) fragmentomes circulation, have shown promise for early detection may provide useful...
<p>Calibration curves for “3rd Generation” Simoa assays.</p>
<p>Additional second-generation ORF1p Simoa assay measurements in healthy and cancer patients.</p>
<p>Assay validation for second-generation ORF1p Simoa assays.</p>