Arturo Loaiza‐Bonilla
A5060268370- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Renal cell carcinoma treatment
- COVID-19 and healthcare impacts
- Economic and Financial Impacts of Cancer
- Artificial Intelligence in Healthcare and Education
- Cancer Treatment and Pharmacology
- Genetic factors in colorectal cancer
- COVID-19 Clinical Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastrointestinal Tumor Research and Treatment
- Biosimilars and Bioanalytical Methods
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- AI in cancer detection
- Healthcare cost, quality, practices
- Cancer Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Global Cancer Incidence and Screening
- Colorectal Cancer Surgical Treatments
Capital Health
2024
Capital Health Medical Center Hopewell
2023-2024
Cancer Treatment Centers of America
2017-2022
City of Hope
2022
University of Pennsylvania
2013-2019
University of Miami
2012-2018
Jackson Memorial Hospital
2012-2018
Beth Israel Deaconess Medical Center
2018
Pontificia Universidad Javeriana
2016-2017
The Ohio State University
2017
Patients with cancer may be at high risk of adverse outcomes from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We analyzed a cohort patients and 2019 (COVID-19) reported to the COVID-19 Cancer Consortium (CCC19) identify prognostic clinical factors, including laboratory measurements anticancer therapies. active or historical laboratory-confirmed SARS-CoV-2 diagnosis recorded between 17 March 18 November 2020 were included. The primary outcome was severity measured...
Autophagy is a mechanism of treatment resistance to chemotherapy that has role in the maintenance pancreatic cancer. Hydroxychloroquine sulfate (HCQ) an inhibitor autophagy inhibits fusion autophagosome lysosome.To determine whether HCQ improves overall survival at 1 year combination with gemcitabine hydrochloride and nab-paclitaxel (GA) among patients metastatic cancer.Open-label, phase 2 randomized clinical trial conducted between March 18, 2013, November 16, 2017, University Pennsylvania,...
5-fluorouracil, leucovorin, irinotecan and oxaliplatin (FOLFIRINOX) is superior to gemcitabine in patients with metastatic pancreatic cancer who have a good performance status. We investigated this combination as neoadjuvant therapy for locally advanced (LAPC).In retrospective series, we included unresectable LAPC received FOLFIRINOX growth factor support. The primary analysis endpoint was R0 resection rate.Eighteen treatment-naïve or borderline resectable were treated FOLFIRINOX. median age...
<h3>Importance</h3> COVID-19 is a life-threatening illness for many patients. Prior studies have established hematologic cancers as risk factor associated with particularly poor outcomes from COVID-19. To our knowledge, no beneficial role anti–COVID-19 interventions in this at-risk population. Convalescent plasma therapy may benefit immunocompromised individuals COVID-19, including those cancers. <h3>Objective</h3> evaluate the association of convalescent treatment 30-day mortality...
<h3>Importance</h3> Non-Hispanic Black individuals experience a higher burden of COVID-19 than the general population; hence, there is an urgent need to characterize unique clinical course and outcomes in patients with cancer. <h3>Objective</h3> To investigate racial disparities severity presentation, complications, between non-Hispanic White cancer COVID-19. <h3>Design, Setting, Participants</h3> This retrospective cohort study used data from Cancer Consortium registry March 17, 2020,...
Background This two-stage, multi-institutional, randomized phase 2 trial assessed the toxicity and response rate associated with two treatment schedules of histone deacetylase inhibitor, vorinostat (suberoylanilide hydroxamic acid; SAHA) in patients relapsed acute myeloid leukemia selected untreated high-risk leukemia.Design Methods Patients or who were not candidates for chemotherapy entered one arms. In both arms a total dose 8400 mg was delivered each 21-day cycle treatment: arm A regimen...
The KRAS oncogene is a driver mutation and present in greater than 90% of pancreatic ductal adenocarcinomas (PDAC). A subset these tumors, however, do not harbor mutations (wild type KRAS). Studies have shown that patients with mutated poorer survival on first-line gemcitabine-based chemotherapy compared to wild KRAS. In this study, we examined cohort PDAC at our institution who were either or mutant for the gene assessed differences response different chemotherapeutic regimens.We clinical...
<h3>Importance</h3> Androgen deprivation therapy (ADT) has been theorized to decrease the severity of SARS-CoV-2 infection in patients with prostate cancer owing a potential tissue-based expression coreceptor transmembrane protease, serine 2 (TMPRSS2). <h3>Objective</h3> To examine whether ADT is associated decreased rate 30-day mortality from among cancer. <h3>Design, Setting, and Participants</h3> This cohort study analyzed patient data recorded COVID-19 Cancer Consortium registry between...
This is the case of a 47-year-old woman diagnosed with chemotherapy and radiation-refractory BRAF V600E mutant, poorly differentiated intrahepatic cholangiocarcinoma (ICC), multiple metastatic lesions within liver, lungs, pleura, bone, stage IV. Discussion her malignancy's next-generation sequencing genomic information at multidisciplinary molecular tumour board took place. The patient was considered suitable candidate for dual MEK inhibition, intent to prolong survival optimize quality...
Introduction: Early cancer detection can lead to improved outcomes and a shift toward prevention model. This review explores the role of artificial intelligence (AI) in early detection, focusing on its application various clinical settings.
This is the case of an 84-year-old woman diagnosed with Stage IVb colon adenocarcinoma (CRC) metastatic to liver, retroperitoneum, anastomotic site, and distal rectal sigmoid colon. She experienced intolerable side effects systemic chemotherapy 5-fluorouracil bevacizumab, as well disease progression. Next generation sequencing her tumor was ordered, further discussion malignancy's genomic information took place at a multidisciplinary molecular board. The patient had mutations in KRAS...
3545 Background: Colorectal cancer (CRC) cells can become resistant to chemotherapy and anti-angiogenic therapy through autophagy. The antimalarial agent hydroxychloroquine (HCQ) is a potent inhibitor of autophagy, in vivo studies CRC cell models show significant decrease tumor volume when these autophagy inhibitors were combined with oxaliplatin bevacizumab. We previously reported safety HCQ 600mg BID combination standard front-line FOLFOX bevacizumab Phase I study metastatic patients....
The COVID-19 pandemic has had a distinct spatiotemporal pattern in the United States. Patients with cancer are at higher risk of severe complications from COVID-19, but it is not well known whether outcomes this patient population were associated geography. To quantify variation among patients cancer. This registry-based retrospective cohort study included historical diagnosis invasive malignant neoplasm and laboratory-confirmed SARS-CoV-2 infection between March November 2020. Data...
Background: Prior reports have demonstrated inferior outcomes for patients with right-sided colorectal cancer (CRC) compared to left-sided disease, as well differences in treatment response based on disease sidedness. Differences prognosis remain even among metastatic indicating that anatomy or stage at diagnosis alone cannot explain all of these findings. While genetic between right- and CRC long been described, the molecular drivers underlying incompletely understood. Methods: We mutation...
Cancer somatic genetic evolution is a direct contributor to heterogeneity at the clonal and molecular level in colorectal adenocarcinoma (COAD). We sought determine extent which may be detected COAD routinely obtained single clinical specimens establish significance with regard clinicopathologic outcome data. One hundred twenty three cases of collected mismatch repair proficient were sequenced on Illumina Truseq Amplicon assay. Measures intratumoral preferential timing mutational events...
Combination nab-paclitaxel/gemcitabine (AG) is superior to gemcitabine in patients with metastatic pancreatic cancer (PC). There are limited data for AG borderline resectable (BR) or locally advanced (LAPC). Herein, we report our experience neoadjuvant BR/LAPC ineligible FOLFIRINOX.This retrospective series, included who received as therapy 3-4 months followed by radiation, then re-evaluation surgery.Between 10/2013-2/2018, 32 (22 BR, 10 LAPC) were treated this approach. Median age was 70...
We report the case of a woman with history hypertension and hyperlipidemia presenting recurrent episodes consistent clinically cerebrovascular accidents (CVA), MRI changes suggestive ischemia versus vasculitis as their cause. No anatomical neurological, rheumatic, cardioembolic, or arteriosclerotic etiologies could be determined by extensive workup. Incidentally, patient was found to have prolonged activated Partial Thromboplastin Time (aPTT) normal Prothrombin (PT); further testing revealed...
In July 2019, bevacizumab-awwb and trastuzumab-anns were marketed in the USA as first therapeutic oncology biosimilars. We aimed to investigate initial real-world use of for cancer management US practices.A retrospective, observational analysis data from patients (⩾18 years age) was carried out describe during 12 months following their market entry, using structured Flatiron Health electronic health record-derived database.A total 2952 2997 with recorded trastuzumab-anns, respectively,...
447 Background: A+B is the standard first-line (1L) treatment for uHCC based on IMbrave150 trial, which demonstrated superior efficacy over sorafenib with longer median overall survival (19.2 vs 13.4 months) and progression-free (6.8 4.3 among patients Child Pugh (CP) A cirrhosis. Evidence about use outcomes in routine clinical practice, including impaired liver function, remains limited. Methods: This retrospective observational study included adult who initiated 1L within The US Oncology...