A5067678529- Glioma Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Cancer and Skin Lesions
- Metastasis and carcinoma case studies
- Lymphoma Diagnosis and Treatment
- AI in cancer detection
- Breast Lesions and Carcinomas
- Teratomas and Epidermoid Cysts
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Reproductive System and Pregnancy
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Gastric Cancer Management and Outcomes
- Endometriosis Research and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Meningioma and schwannoma management
- Cutaneous Melanoma Detection and Management
- HER2/EGFR in Cancer Research
- Hematopoietic Stem Cell Transplantation
- Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Acute Myeloid Leukemia Research
Istanbul Medipol University
2015-2024
Dokuz Eylül University
2016-2024
Gebze Technical University
2024
Sağlık Bilimleri Üniversitesi
2024
University of Health Science
2024
Istanbul University
1993-2019
Gazi University
2008-2014
Sivas State Hospital
2011-2013
State Hospital
2012
Abstract Artificial intelligence (AI) has shown promise for diagnosing prostate cancer in biopsies. However, results have been limited to individual studies, lacking validation multinational settings. Competitions be accelerators medical imaging innovations, but their impact is hindered by lack of reproducibility and independent validation. With this mind, we organized the PANDA challenge—the largest histopathology competition date, joined 1,290 developers—to catalyze development...
The Gleason score is the most important prognostic marker for prostate cancer patients, but it suffers from significant observer variability. Artificial intelligence (AI) systems based on deep learning can achieve pathologist-level performance at grading. However, of such degrade in presence artifacts, foreign tissue, or other anomalies. Pathologists integrating their expertise with feedback an AI system could result a synergy that outperforms both individual pathologist and system. Despite...
There are virtually no data in the literature regarding incidence, patterns, and clinicopathologic characteristics of mucinous carcinomas (MCs) gallbladder (GB).To determine incidence differentiation invasive GB those that qualify as MC.Primary (n = 606) were reviewed for differentiation. Some degree mucin production was identified 40 cases (6.6%); however, only 15 (2.5%) qualified World Health Organization definition MC (stromal deposition constituting >50% tumor).The mean age 65 years,...
We describe a clinicopathologically distinct subtype of cholecystitis, the extensively calcific version which has been presented in clinical literature as "porcelain gallbladder (PG)." This we propose to refer hyalinizing cholecystitis (HC), is characterized by dense, paucicellular hyaline fibrosis transforming (GB) wall into relatively thin and uniform band. The process diffusely effaces most normal structures GB, some cases show calcifications. To determine clinicopathologic associations...
Breast carcinomas can be classified into five subtypes based on gene expression profiling or immunohistochemical characteristics. Among these subtypes, basal-like breast (BLBCs) are one of the most studied group, due to their poor prognosis. The aim this study was investigate prevalance, morphological and features BLBCs, in Turkish population. Five hundred invasive were reviewed for several immunostained oestrogen progesterone receptors, c-ERB-B2, cytokeratin5/6, cytokeratin14, vimentin...
Objectives The aims of this study are to evaluate expressions Ki67, RacGAP1 (MgcRacGAP) and topoisomerase 2 alpha (TOP2a), the markers related with cell proliferation that have been proposed affect prognosis in literature correlate results clinicopathological parameters breast cancer patients. Methods RacGAP1, TOP2a antibodies were applied immunohistochemically tissue micrarray blocks 457 female correlated clinical, prognostic, histopathological features, other immunohistochemical findings...
Abstract Background: In support of Project LUNGMARK, LUNGBANK was established as a pioneering biorepository dedicated to lung cancer. Designed for streamlined biospecimen handling, it employs high-volume technologies secure high-quality samples. Fortified with robust data management, efficiently integrates diverse datasets. This strategic infrastructure positions more than repository; operates sophisticated platform advanced cancer research, amplifying the potential meaningful discoveries....
Group 2 innate lymphoid cells (ILC2) can be activated by interleukin (IL)-33 or IL-25. IL-25-activated ILC2 help protect the host against helminth infection while exacerbating allergic-like inflammation and tissue damage in lung. In context of cancer, IL-33-activated were found to bear anti-tumoral functions lung cancer promoted tumorigenesis colorectal cancer. The role remains addressed.We examined overall survival human non-small cell (NSCLC) patients according IL25 expression as well...
Lymph node involvement is an important prognostic factor in patients with gastric cancer. The aim of this study was to determine the significance metastatic lymph ratio (MLNR) and compare it number metastasis pN3 cancer.We retrospectively analyzed 207 cancer who had undergone radical gastrectomy. Prognostic factors MLNR were evaluated by univariate multivariate analysis.An 0.75 found be best cut-off value prognosis (p = 0.001). significantly higher large-sized undifferentiated tumors,...
Cervical carcinoma is one of the frequently seen cancers in world and our country, develops from precursor lesions. These lesions are analyzed by pathologists so that diagnosis disease can be made. In this study, a system performs automatic detection pre-cancerous was performed using convolutional neural networks (CNNs). training phase, lesion recognition performance proposed has reached 92%. Thereafter, whole image segmented 60 × pixel tiles during phase. After all, were with 81.71% Dice...
Programmed death-ligand 1 (PD-L1) is suggested to be a predictive biomarker in non-small-cell lung carcinoma (NSCLC). However, the differential expression of PD-L1 primary tumor vs. synchronous metastases, especially brain metastasis (BM), remains unclear. This study assessed concordance on cells and infiltrating lymphocytes (TILs) CD8+ TIL intensity between tumors BMs from 24 NSCLC patients. PD-L1, CD3, CD8 positivity was determined by immunohistochemistry (IHC). scoring based proportion...
A subungual exostosis (SE) is a bony overgrowth that permanently attached to the tip of distal phalanx. Its pathology differs from osteocartilaginous exostoses in it mainly involves normal bone, which may present beneath toenail or on sides toe. This retrospective study aimed report results surgical treatment when diagnosis SE was delayed; condition initially considered be another affecting different nail terminal toe.A total 17 patients (12 female, five male) were included study. All...
The current study was designed to assess the response treatment, as well clinical and survival outcomes, across different breast cancer subtypes in patients who underwent neoadjuvant chemotherapy (NAC). From 2014 2019, a total of 139 were histologically confirmed have cancer, NAC, subsequently received axillary surgery, retrospectively included this study. rates pathological complete (pCR) NAC significantly higher for HER2-positive triple-negative than luminal A HER2-negative (p = 0.013)....
Backround: The purpose of this study was to evaluate the outcomes different radiotherapy techniques used in routine clinical practice for radical treatment hypopharyngeal cancer and assess improvements over last few decades. Methods: We compared patients with squamous cell carcinoma treated curative (RT) or chemoradiotherapy between January 1992 December 2020, using 2D-RT, 3D-CRT/IMRT, VMAT techniques. A retrospective analysis conducted on eighty-one cancer. Results: median follow-up time 26...
Prostate adenocarcinoma is the most common malignancy and second leading cause of cancer related deaths in men. Testicular liposarcomas are uncommon soft tissue neoplasms. We report coexistence prostate testicular liposarcoma a 69 year-old-man because while orchiectomy endications decreasing day by day, these malignancies should not be missed.
Schistosomiasis is a rare condition in Turkey but remains second most prevelant parasitic infestation worldwide.A 67-years old male patient admitted to hospital with macroscopic hematuria. Bladder tumor was diagnosed and referred our department for the treatment. Transurethral resection of bladder performed pathological examination revealed high-grade papillary urothelial carcinoma Schistosoma mansoni eggs. The used praziquantel 40mg orally treatment intravesical immunotherapy applied 6...
This study aims at evaluating the endometrial receptivity in uterus of pregnant rats exposed to nicotine via examination integrin expression by immunohistochemical effect.In this study, 16 healthy were divided into two groups control and each comprising eight rats. The randomised group given a certain amount before during pregnancy. Integrin was detected all staining. effect exposure on embryo implantation immunohistochemically pathologically evaluated.Comparison both revealed no difference...