A5028066920- Inflammatory Biomarkers in Disease Prognosis
- COVID-19 Clinical Research Studies
- Ocular Surface and Contact Lens
- Gastric Cancer Management and Outcomes
- Blood Coagulation and Thrombosis Mechanisms
- Salivary Gland Disorders and Functions
- Long-Term Effects of COVID-19
- Psoriasis: Treatment and Pathogenesis
- Venous Thromboembolism Diagnosis and Management
- Reproductive System and Pregnancy
- SARS-CoV-2 and COVID-19 Research
- Pregnancy and Medication Impact
- Bariatric Surgery and Outcomes
- Pregnancy and preeclampsia studies
- Sulfur Compounds in Biology
- COVID-19 diagnosis using AI
- Colorectal Cancer Treatments and Studies
- Ovarian cancer diagnosis and treatment
- Thyroid Cancer Diagnosis and Treatment
- Hemoglobinopathies and Related Disorders
- Protease and Inhibitor Mechanisms
- Urticaria and Related Conditions
- Liver Disease Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Lung Cancer Treatments and Mutations
Istanbul Medipol University
2015-2025
Weatherford College
2021
Türkisch-Deutsche Universität
2021
Istanbul University
2018
Austrian Society of Dermatology and Venereology
2016
Dokuz Eylül University
2008
COVID-19 is associated with mitochondrial dysfunction and metabolic abnormalities, including the deficiencies in nicotinamide adenine dinucleotide (NAD
This study aimed to define the clinical course of anosmia in relation other symptoms.
Cardiac metastasis is rarely detected in oncology practice. Herein we present a rare case of metastatic gastric cancer that metastasized to the right atrium and presented with heart failure. A 51-year-old male patient no known chronic disease fatigue, abdominal distension leg edema for 3 weeks. Physical examination revealed ascites, tachycardia pretibial edema. Transthoracic echocardiography (TTE) hypoechoic, less-mobile mass almost completely filled atrium. Moreover, 18F-fluorodeoxyglucose...
Background and Objectives: Epithelial ovarian cancer (EOC) remains a significant global health challenge. While traditional prognostic factors are well established, emerging biomarkers continue to gain attention. Materials Methods: This retrospective study evaluated the impact of systemic inflammatory markers on progression-free survival (PFS) overall (OS) in 154 EOC patients. Pre-treatment neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte (PLR), index (SII) were calculated categorized...
Background/Objectives: This study aimed to investigate the prognostic and predictive significance of ATM expression in patients with metastatic non-small cell lung cancer (NSCLC) treated pembrolizumab. Methods: A retrospective analysis was conducted on 49 NSCLC who received first-line pembrolizumab as a single agent or combination chemotherapy. Immunohistochemistry used assess archival pathology specimens. Nuclear staining considered positive. categorized into low high groups based combined...
The aim of this study was to evaluate tear film function in patients with vitamin D deficiency.In a single center, 60 eyes 30 deficiency (group 1), and healthy individuals 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, break-up time (TBUT), scoring ocular surface fluorescein staining modified Oxford scale, osmolarity.Tear osmolarity values, OSDI, scale scores significantly higher group 1 (309±9 mOsm/L, 35.78±21.44 1.3±0.9, respectively)...
Disorders in the metabolism of homocysteine and B vitamins, which are involved a one-carbon transfer reaction important for DNA synthesis methylation, have been hypothesized to be associated with carcinogenesis. The purpose this study is evalu-ate levels homocysteine, vitamin B12 folic acid patients newly diagnosed lung cancer determines whether they might used as an accurate tumor marker monitoring if found elevated cancer.Forty male were included study. Age-matched forty healthy males who...
Purpose: The aim of this study was to evaluate tear osmolarity and film function ocular surface changes in patients with metabolic syndrome.Methods: 108 eyes 64 syndrome (group 1) 110 55 healthy individuals 2) were included cross-sectional study. All participants evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, break-up time (TBUT), osmolarity. Main outcome measures values.Results: Tear values OSDI scores significantly higher group 1 (314.4 ± 19.1 mOsm...
Lymph node involvement is an important prognostic factor in patients with gastric cancer. The aim of this study was to determine the significance metastatic lymph ratio (MLNR) and compare it number metastasis pN3 cancer.We retrospectively analyzed 207 cancer who had undergone radical gastrectomy. Prognostic factors MLNR were evaluated by univariate multivariate analysis.An 0.75 found be best cut-off value prognosis (p = 0.001). significantly higher large-sized undifferentiated tumors,...
The aim of this study was to evaluate tear osmolarity, film function, and ocular surface changes in patients with psoriasis.At a single center, 30 eyes psoriasis (group 1) healthy individuals 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, break-up time (TBUT) scoring fluorescein staining modified Oxford scale, osmolarity measurement.Tear values, OSDI, scale scores significantly higher group 1 (309.8 ± 9.4 mOsm, 38.9 1.1, 0.7 respectively) than...
Cytomegalovirus (CMV) disease is an important complication and independent risk factor for acute rejection recipient morbidity-mortality. The aim of this study was to review the results CMV in renal transplant recipients.We have retrospectively analyzed 120 recipients recorded demographic features, clinical manifestations, immunosuppressive regimens.Twenty-nine (24.1%) developed after a median interval 2.8 +/- 2,6 months from transplantation. 36.3% who received basiliximab as induction...
Abstract The aim of this study was to investigate the predictive and prognostic value PLR, relationship between PLR tumor localization. A total 229 patients with de-novo metastatic CRC were retrospectively analyzed. cutoff for defined by receiver operating characteristic (ROC) curve analysis threshold 196.5 as best cut-off found. higher rate BRAF mutation significantly detected high (> 196.5) compared those low (≤196.5) ( P = .001). in tumors located on right colon .012). localization,...
ABSTRACT There is a need to treat COVID-19 patients suffering from respiratory problems, resulting in decreased oxygen levels and thus leading mitochondrial dysfunction metabolic abnormalities. Here, we investigated if high oral dose of mixture Combined Metabolic Activators (CMA) can restore function aid the recovery patients. We conducted placebo-controlled, open-label phase 2 study double-blinded 3 clinical trials investigate time symptom-free on ambulatory using CMA consisting NAD+...
To evaluate the effect of fibrin glue on staple-line leak after sleeve gastrectomy.Fourteen adult wistar rats 300 gr were randomized into two groups: Control group (n=7) and study (n=7). All underwent gastrectomy using lineer stapler. In group, was used to reinforce staple-line. The sacrificed 7 days surgery. stomach resected, submerged in saline exposed excess pressure obtain a burst value. gastric staple line evaluated histopathologically according Ehrlich Hunt scale. results groups...
Background/aim: A SARS-Cov2 infection which was first arised from Wuhan in December 2019 and named as COVID-19. Still there lacks either a specific treatment or vaccine to treat Convalescent plasma (CP) previously used successfully SARS-CoV-1 MERS infections. Health authority Turkey has published guideline integrate this promising option the process of patients who are prone high risk developing severe COVID 19. Materials Methods: Forty consecutive had received CP at our center were included...
Amaç: Psoriazis vulgaris oksidatif stres ve dokuda enflamasyon ile seyreden kronik, sistemik enflamatuvar bir hastalıktır.Tiyol disülfit seviyelerinin total oksidan durumun belirteci olarak hastalıklarda arttığı gösterilmiştir.Bugüne kadar, seboreik dermatit, atopik alopesi areata, akut ürtiker melasma gibi birçok dermatolojik hastalıkta tiyol/disülfit homeostazındaki dengesizlik ya da anormalliklerin etiyopatogenetik rolü olduğu gösterilmiştir.Psoriazis vulgariste tiyol kan oranlarının...
Background/aim: Recent evidence suggests that Vitamin D deficiency may be associated with varying degrees of peripheral blood cytopenia(s). However, the effect on hematopoiesis is largely unknown. According to predefined inclusion criteria, here we analyzed correlation between serum level and hematological parameters. Materials methods: In present cohort study, a total 12.709 patients were screened. first data set, all included. in second one, only (9.936) no complete count (CBC) abnormality...
Objective: Radial artery spasm (RAS), is a major drawback for the routine use of radial Access during coronary interventions and anxiety well-documented predictor RAS. In this study, we aimed to assess relationship between RAS level (LOA) which was quantified with different scales. Material Methods: 123 consecutive patients scheduled elective angiography were enrolled. Demographic procedural relevant features noted, then, asked fill three scales; Beck Anxiety Inventory (BAI), Spielberger...
Background/Objectives: Studies attempting to predict the development of severe respiratory failure in patients with a COVID-19 infection using machine learning algorithms have yielded different results due differences variable selection. We aimed failure, defined as need for high-flow oxygen support, continuous positive airway pressure, or mechanical ventilation, COVID-19, identify most important variables achieving this prediction. Methods: This retrospective, cross-sectional study included...
Epithelial ovarian cancer (EOC) remains a significant health burden globally. While traditional prognostic factors are well-established, newer biomarkers emerging. This retrospective study aimed to investigate the impact of systemic inflammatory markers on progression-free survival (PFS) and overall (OS) in 154 EOC patients. Pre-treatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), index (SII) were calculated categorized into low high groups. Univariate multivariate...
INTRODUCTION: Restless legs syndrome (RLS) is characterized by an uncomfortable sensation on the legs, which causes urge to move legs. The main cause unknown but there are many risk factors, including geographical properties and high altitude. Our objective was explore frequency of RLS in aircrew.METHODS: There were 301 Turkish aircrew who admitted Istanbul Medipol University Hospital Neurology Department for periodic examinations 272 healthy (non-aircrew) subjects included study....
Background: There is still limited knowledge regarding the role of impaired brain glucose metabolism in generation aggression during diabetes. Additionally, there are rapidly replicating piece evidence suggesting that topiramate may exert significant mood stabilizing effect. In this respect, we aimed to evaluate neurometabolic correlates therapeutic effect a patient with diabetes and Intermittent explosive disorder (IED). Methods: We measured regional cerebral using...