Comorbidity, the most important components of which are hypertension/coronary artery disease (HTN/CAD), diabetes mellitus (DM), and chronic obstructive pulmonary (COPD), is frequently encountered in small cell lung cancer (SCLC) patients. We aimed to assess possible impacts these major comorbidities on prognoses SCLC A total 378 patients were analyzed retrospectively. did not ascertain effect comorbidity survival general; similarly, presence HTN/CAD COPD adversely affect outcome. However,...

Melanoma is among the most common tumors that disseminate to brain. We analyzed patients with resected early-stage cutaneous melanoma who developed sole brain metastases and accompanying other organ spreads interpreted clinical characteristics of these in this study. A total 457 any during or after adjuvant therapy follow-up were included analysis. 55 (12%) had (M1d), 402 (M1a,b,c) metastases. The majority ( n = 36, 65.4%) accompanied by metastases, only 19 Brain mostly men (76.4 vs. 61.9%,...

This review examines the role of gut microbiota in activation Wnt/β-catenin signaling pathway and its impact on cancer progression via YAP/TAZ activation. Yes-associated protein, YAP, is a transcriptional coactivator involved regulating gene expression cell proliferation by interacting with TEA domain (TEAD) transcription factor Hippo pathway. The an evolutionarily conserved that important for development tissue homeostasis but was described as driving oncogenic processes through activity....

Nearly one-third of all melanoma patients will experience disease recurrence and the majority relapses eventually develop metastatic as a consequence progression in early-stage patients. As very few number studies have investigated natural history cutaneous at first relapse, we analyzed time until along with patterns outcomes this retrospective study. A total 332 who were initially diagnosed nonmetastatic developed during course and/or follow-up included analysis. Locoregional relapse alone...

OBJECTIVE:In this study, we aimed to compare the cardiovascular risk factors that might be associated with inflammation, atherosclerosis and metabolic syndrome between hemodialysis peritoneal dialysis patients.METHODS: Fifty 50 patients who had been receiving therapy for at least one year were included in study.Venous blood samples taken after 12 hours of fasting, serum glucose, triglyceride, low-density lipoprotein (LDL)-cholesterol, high-density (HDL)-cholesterol, C-reactive protein,...

Regression is caused by a host immunological response primarily characterized lymphocytic infiltration directed against melanoma cells. The prognostic significance of regression remains controversial in cutaneous patients. aim this study was to determine the clinical histological status patients with melanoma. A total 664 pathologically confirmed were enrolled into and investigated retrospectively. median age 51 years, ranging from 16 104 years. majority them had lesions without (n=495;...

A small subset of head and neck melanoma, scalp melanoma comprises 3-5% all cutaneous melanomas. So far, numbers researches on have yielded controversial results. In this trial, we aimed to define the histopathological clinical features specific compare them with melanomas that occurred other sites by using a large group patients from single institution. The data 93 1076 were analyzed retrospectively. median age was 53 (range 18-83) years. found more frequently in male (79.6 vs. 52.0%,...

Insulin-like growth factor-1 (IGF-1) and its essential binding protein-3 (IGFBP-3) exhibit significant roles in cellular proliferation, differentiation apoptosis numerous malignancies, including lung cancer. The aim of the present study was to determine clinical serum IGF-1 IGFBP-3 levels cancer patients. A total 80 patients with were enrolled study. Serum concentrations determined by ELISA methods. median age 58.5 years old, a range 36-80 years. majority had non-small cell (NSCLC) (85%)...

Tumor infiltrating lymphocytes (TILs) invade and disrupt melanoma cells their clinical roles remain controversial. In this study, we aimed to determine the significance of TILs status in cutaneous patients (CMPs). Of 750 CMPs enrolled into study 486 (64.8%) had lesions with TILs. The more likely nodular histology, presence histological regression, absence regional lymph node involvement. However, its was not associated outcome. conclusion, may be only an independent predictor for nodal...

Patient age has been reported as a highly significant and strong predictor of the outcome in patients with cutaneous melanoma. The aim present study was to determine clinical significance patient Turkish A total 1,169 pathologically proven melanoma were enrolled. Age classified young (<40 years), middle-aged (40-59 years) old (≥60 years). median 51 years (range, 16-104 Non-superficial spreading histology significantly more observed than other groups (P<0.001). lower Clark invasion level...

Disorders in the metabolism of homocysteine and B vitamins, which are involved a one-carbon transfer reaction important for DNA synthesis methylation, have been hypothesized to be associated with carcinogenesis. The purpose this study is evalu-ate levels homocysteine, vitamin B12 folic acid patients newly diagnosed lung cancer determines whether they might used as an accurate tumor marker monitoring if found elevated cancer.Forty male were included study. Age-matched forty healthy males who...

Elevated erythrocyte sedimentation rate (ESR) is common in cancer patients and it may affect survival. However, its clinical role prognostic significance remain unknown melanoma patients. The objective of the present study was to determine ESR levels cutaneous A total 139 were enrolled this retrospectively investigated. median age 52 years (range, 16‑88 years). 22 mm/h 2‑122 mm/h). Significant differences found be associated with sex, histology, blood hemoglobin level, lactate dehydrogenase...

Abstract: The histological subtype is not considered one of the major prognostic factors in melanoma, yet it known to have an impact on survival. aim this study was investigate clinical significance subtypes and possible impacts clinicopathological course melanoma patients all stages. A total 1017 cutaneous were analyzed retrospectively. Four histotypes that studied as follows: (1) superficial spreading (SSM), (2) nodular (NM), (3) acral lentiginous (ALM), (4) lentigo maligna (LMM). Unlike...

Background: Cellular heat shock proteins (HSPs) play significant roles in sustaining normal cellular conditions. The stimulated expressions of HSPs result stabilization at times stress, such as cancer. objective this study was to determine the clinical significance serum levels HSP90 melanoma patients. Material and methods: A total number 98 patients were enrolled into study. Serum concentrations determined by solid-phase sandwich ELISA method. Age sex matched 43 healthy controls included...

Many studies suggested that cytokines interleukin (IL)-29, IL-32, and tumor necrosis factor alpha (TNF-α) are implicated in the pathogenesis of malignancies. The purpose this study was to determine clinical significance serum levels IL-29, TNF-α gastric cancer (GC) patients. Fifty-eight GC patients 20 age- sex-matched healthy controls were enrolled into study. median age at diagnosis 59.5 years (range 32-82 years). Tumor localization majority antrum (n = 42, 72.4 %), histopathology diffuse...

The prognostic significance of BRAF mutations in the natural course melanoma is controversial. aim study was to assess V600E mutation cutaneous patients. A total 151 melanomas were included study. detected using real-time PCR. rate 51%. higher for young patients (61.4%) and upper limbs (63.2%), trunk (59.3%) head neck (59.2%) most frequently afflicted sites BRAF-mutant patients, whereas lower mostly affected BRAF-wild (77.8%). Likewise, acral rarely harbored (17.1%). disease-free survivals...

&lt;b&gt;&lt;i&gt;Background/Aims:&lt;/i&gt;&lt;/b&gt; Acral lentiginous melanoma (ALM) is a small subtype of affecting Caucasians far more often than other ethnic groups, such as blacks, Hispanics, and Asians. Only few studies have yielded controversial results on ALM so far. The aim this study was to define the histopathological clinical expressions compare them with those non-ALM in large group Turkish patients from single referral institution....

Background: Even though anxiety and depression are two mood disorders encountered commonly in cancer patients only few trials have been carried out so far melanoma patients. The aim of the study was to determine clinical prevalence these Turkish cutaneous clarify possible clinicopathological factors influencing them. Material methods: A total 100 consecutive outpatient were enrolled asked complete Hospital Anxiety Depression Scale (HADS) questionnaire immediately after scheduled visits....

Systemic treatment options with proven efficacy for the of metastatic uveal melanoma are limited. In this study, we aimed to evaluate nivolumab in patients. our multi-center files patients who received a diagnosis were retrospectively reviewed and their information was recorded. Seventeen enrolledand 16 evaluable efficacy. The objective response rate (ORR) 18% including one confirmed complete two partial responses. median progression-free survival (PFS) 5.8 months (95% CI, 0.03-11.57...

Several previous studies have explored whether sex has prognostic significance in patients with small cell lung cancer (SCLC). In this retrospective study, we aimed to show the clinical of SCLC patients.