<h3>Objective</h3> Epithelial ovarian cancer (EOC) is the leading cause of death among gynecological tumors and usually diagnosed at advanced stage. We aimed to identify clinical prognostic relevance coagulation tests their correlation with serum CA-125 levels in EOC. <h3>Materials Methods</h3> A total 33 advanced-stage (stages III IV) EOC patients were enrolled study. Of these patients, 17 had received neoadjuvant chemotherapy 16 after optimal debulking surgery. Several clinicopathologic...

Insulin-like growth factor-1 (IGF-1) and its essential binding protein-3 (IGFBP-3) exhibit significant roles in cellular proliferation, differentiation apoptosis numerous malignancies, including lung cancer. The aim of the present study was to determine clinical serum IGF-1 IGFBP-3 levels cancer patients. A total 80 patients with were enrolled study. Serum concentrations determined by ELISA methods. median age 58.5 years old, a range 36-80 years. majority had non-small cell (NSCLC) (85%)...

Background: Cellular heat shock proteins (HSPs) play significant roles in sustaining normal cellular conditions. The stimulated expressions of HSPs result stabilization at times stress, such as cancer. objective this study was to determine the clinical significance serum levels HSP90 melanoma patients. Material and methods: A total number 98 patients were enrolled into study. Serum concentrations determined by solid-phase sandwich ELISA method. Age sex matched 43 healthy controls included...

Extracellular metalloproteinase inducer (EMMPRIN) and a disintegrin (ADAM12) play major role in cancer invasion metastasis owing to the fact that they are directly related cell microenvironment extracellular matrix (ECM) degradation. The aim of this study was search for an answer question "whether determination EMMPRIN ADAM12 values especially urine may be helpful early diagnosis prostate without employing invasive methods" also check whether useful patients with high risk. Peripheral blood...

Many studies suggested that cytokines interleukin (IL)-29, IL-32, and tumor necrosis factor alpha (TNF-α) are implicated in the pathogenesis of malignancies. The purpose this study was to determine clinical significance serum levels IL-29, TNF-α gastric cancer (GC) patients. Fifty-eight GC patients 20 age- sex-matched healthy controls were enrolled into study. median age at diagnosis 59.5 years (range 32-82 years). Tumor localization majority antrum (n = 42, 72.4 %), histopathology diffuse...

Insulin-like growth factor-1 (IGF-1) and its primary binding protein-3 (IGFBP-3) play an important role in cellular proliferation, differentiation apoptosis many tumors, including breast cancer (BC). The objective of this study was to determine the clinical significance serum levels IGF-1 IGFBP-3 BC patients. A total 96 patients with a pathologically confirmed diagnosis were enrolled into study. Serum determined by solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) methods. Age-...

Prostate cancer antigen 3 (PCA3) and microRNA-141 (miR-141) are emerging molecules in prostate (PCa) pathogenesis have been shown to be involved androgen signaling. In this original research, we designed an experimental cell model with androgen-sensitive LNCaP cells comparatively assess the extent of responsiveness PCA3-mRNA miR-141 along specific (PSA)mRNA their release into culture medium. These were also measured plasma patients early PCa which is considered analogous androgenresponsive...

The activation of coagulation and fibrinolysis is frequently found among cancer patients. Such tumors are considered to be associated with a higher risk invasion, metastases, eventually worse outcome. aim this study explore the clinical prognostic value blood tests for melanoma Pretreatment including prothrombin time (PT), activated partial thromboplastin (APTT), activity (PTA), international normalized ratio (INR), D-dimer (DD), fibrinogen (F) levels, platelet (PLT) counts were carried out....

Fibronectin and vitronectin are the important components of extracellular matrix proteins. The aim this study was to determine clinical significance these protein serum levels in patients with melanoma. A total 60 a pathologically confirmed diagnosis melanoma were enrolled study. Serum fibronectin concentrations determined using solid-phase sandwich ELISA method. Thirty age-matched sex-matched healthy controls included analysis. baseline significantly higher than those control group (P<0.001...

Recent studies have demonstrated the differential expression of miR‑141 and miR‑375 in circulation patients with advanced/metastatic prostate cancer (PCa). The aim this study was to investigate regulation by androgens their release into incubation medium relation prostate‑specific antigen (PSA) mRNA 3 (PCA3). Plasma levels these molecules were measured a small cohort localized PCa. As an vitro cell model we used androgen‑sensitive LNCaP cells exposed androgen ablation 48 h, then treated...

Background: Angiogenesis plays an essential role in tumor growth and serum levels of YKL-40 , a strong angiogenic factor that promotes vessel development, has been found to be elevated various cancers. We here investigated correlation between melanoma parameters levels, assess potential diagnostic, prognostic predictive values. Material Methods: Data for 112 pathologically confirmed cutaneous melanomas any stage were examined retrospectively. ELISA assays used measure plasma samples....

The aim of the present study was to evaluate correlations between serum osteocalcin, osteoprotegerin and NTX (Cross-linked N-telopeptides Type I Collagen) urinary in breast lung cancer patients with bone metastases. These four markers are considered have important roles formation, resorption metastases.Four were determined sera 60 21 healthy controls (n=30). Serum levels studied using ELISA EIA.The median (p<0.001) osteocalcin (p=0.003) higher patients. Significant observed NTX-osteocalcin...

Fibronectin is an important component of the extracellular matrix and serves a role in pathogenesis multiple malignancies. The expression fibronectin also affects outcome for patients with cancer. objective present study was to determine clinical significance serum levels gastric A total 63 pathologically confirmed diagnosis cancer were enrolled into study. Serum concentrations determined by solid-phase sandwich enzyme-linked immunosorbent assay method. Age sex matched healthy controls...

M30 and M65 are relatively new assays that detect different circulating forms of the epithelial cell structural protein cytokeratin 18. This study was conducted to investigate serum levels in patients with metastatic pancreatic adenocarcinoma (MPA) relationship tumor progression known prognostic parameters. Twenty-six MPA were investigated. Serum samples obtained on first admission before treatment follow-up. Both determined using enzyme-linked immunosorbent assay. The median age at...

Cellular adhesion molecules might be good markers in some types of malignant tumors and provide useful information diagnosis prognosis. The objective this study was to determine the clinical significance serum levels vascular cell molecule-1 (VCAM-1) lung cancer patients treated with platinum-based chemotherapy. One hundred thirty were enrolled into study. Serum VCAM-1 determined by solid-phase sandwich ELISA method. Age- sex-matched 34 healthy controls included analysis. Median age 58 years...

Cellular adhesion molecules are considered useful markers in the diagnosis and prognosis of several types malignant tumors. Laminin, a major structural component basement membrane, is strong promoter cell adhesion, migration, differentiation proliferation via integrins other surface receptors. The present study aimed to evaluate clinical significance serum level laminin lung cancer patients. A total 80 patients with were enrolled study. was measured by solid‑phase sandwich enzyme-linked...

This study was conducted to investigate the serum levels of membrane-bound mucin 2 (MUC2) in breast cancer (BC) patients and relationship with tumour progression known prognostic parameters. We enrolled 127 female histopathologically diagnosed BC who did not receive chemotherapy (CT) or radiotherapy. Serum MUC2 were measured by enzyme-linked immunosorbent assay (ELISA) method compared those 40 age sex-matched healthy controls. Median diagnosis 50 (range: 26⁻78). Twenty-eight (22%) metastatic...

The aim of the present study was to evaluate serum neuron-specific enolase (NSE) levels in patients with prostate cancer, Hodgkin lymphoma, lung cancer and peripheral nerve tumors.NSE were determined by ELISA sera 100 47 35 tumor also 132 healthy controls.The median NSE elevated (p=0.018) tumors (p=0.008). lymphoma higher than controls but there no statistically significant difference (p>0.05).We conclude that may be applied routine gain insight about clinical statuses various patients, more...