A5047744191- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Colorectal Cancer Surgical Treatments
- Cell Adhesion Molecules Research
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Cancer Treatment and Pharmacology
- Neuroendocrine Tumor Research Advances
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Caveolin-1 and cellular processes
- HER2/EGFR in Cancer Research
- Cancer, Lipids, and Metabolism
- Renal cell carcinoma treatment
- Multiple and Secondary Primary Cancers
- Cancer Risks and Factors
- Galectins and Cancer Biology
- Neuroblastoma Research and Treatments
Istanbul University
2015-2024
Bahçeşehir University
2022
Bezmiâlem Vakıf Üniversitesi
2016
Selçuk University
2014-2016
Marmara University
2015
Necmettin Erbakan University
2012-2015
Kafkas University
2008
ABSTRACT Background: Bone metastasis is rarely seen in colorectal cancer (CRC) patients, and there insufficient data available regarding such cases. The study aimed to identify the prognostic factors characteristics associated with overall survival patients bone metastatic CRC. Method: Data from CRC referred a high-volume tertiary center Turkey, between January 2018 April 2021, were retrospectively collected. records of 150 consecutive treated for metastases due reviewed. Overall curves...
Background: Inoperable and metastatic hepatocellular carcinoma (HCC) is associated with a poor prognosis low chemotherapeutic efficiency. Sorafenib an oral multi-kinase inhibitor exerting its effects via the RAF/MEK/ERK pathway, vascular endothelial growth factor receptor (VEGFR) platelet derived beta (PDGFR-<TEX>${\beta}$</TEX>) tyrosine kinases. Randomized studies have shown significant contribution of sorafenib to life expectancy quality cancer patients. The aim present study evaluate...
Tenascin-C (TNC) is an extracellular matrix protein that expressed at low levels in normal adult tissue but highly around many tumors including ovarian tumors. The objective of this study was to determine the clinical significance serum TNC epithelial cancer (EOC) patients. A total 50 patients with a pathologically confirmed diagnosis EOC were included study. Serum determined by solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) method. Age- and sex- matched 28 healthy controls...
Insulin-like growth factor-1 (IGF-1) and its essential binding protein-3 (IGFBP-3) exhibit significant roles in cellular proliferation, differentiation apoptosis numerous malignancies, including lung cancer. The aim of the present study was to determine clinical serum IGF-1 IGFBP-3 levels cancer patients. A total 80 patients with were enrolled study. Serum concentrations determined by ELISA methods. median age 58.5 years old, a range 36-80 years. majority had non-small cell (NSCLC) (85%)...
Pancreas cancer (PCa) is one of the mortal types with ranking as fourth leading death in both sexes together. FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GNP) are approved first-line metastatic treatment PCa. The aim this study was to compare clinical outcomes, treated FFX GNP Medical records patients diagnosed PCa, from January 2010 December 2020 were analyzed. This a retrospective cohort, multi-institution analysis. focus present efficiency chemotherapy combinations Efficacy had...
Introduction: Breast cancer in young women is a relatively rare disease; however it tends to be more aggressive and the leading cause of death this population. The aim study investigate clinical biological features breast arising Turkish patients. Materials Methods: Patients with aged 35 or less (<TEX>${\leq}35$</TEX> years) were selected for study. In total 211 cases included. Pathologic features; histologic subtypes, grade, lymphovascular invasion, axillary involvement, stage recorded...
Disorders in the metabolism of homocysteine and B vitamins, which are involved a one-carbon transfer reaction important for DNA synthesis methylation, have been hypothesized to be associated with carcinogenesis. The purpose this study is evalu-ate levels homocysteine, vitamin B12 folic acid patients newly diagnosed lung cancer determines whether they might used as an accurate tumor marker monitoring if found elevated cancer.Forty male were included study. Age-matched forty healthy males who...
This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines treatment in patients with metastatic neuroendocrine tumors (NETs).
The purpose of this study was to determine the clinical significance vascular cell adhesion molecule-1 (VCAM-1) and epithelial molecule (EpCAM) in breast cancer (BC) patients. Ninety-six BC patients 30 age- sex-matched healthy controls were enrolled into study. Pretreatment serum markers determined by solid-phase sandwich (enzyme-linked immunosorbent assay (ELISA)). median age at diagnosis 48 years (range 29-80 years). Majority (71 %) had luminal subtype, 38.5 % metastatic disease....
Many studies suggested that cytokines interleukin (IL)-29, IL-32, and tumor necrosis factor alpha (TNF-α) are implicated in the pathogenesis of malignancies. The purpose this study was to determine clinical significance serum levels IL-29, TNF-α gastric cancer (GC) patients. Fifty-eight GC patients 20 age- sex-matched healthy controls were enrolled into study. median age at diagnosis 59.5 years (range 32-82 years). Tumor localization majority antrum (n = 42, 72.4 %), histopathology diffuse...
Background: Oesophageal squamous cell carcinoma (ESCC) is endemic in the Eastern Anatolian region of Turkey. The present study was performed to identify risk factors for ESCC that specifically reflect demography and nutritional habits individuals living this region. Materials Methods: following parameters were compared 208 patients 200 control region: age, sex, place living, socioeconomic level, education smoking, alcohol intake, habits, food preservation methods. Results: mean age 56.2...
The efficacy and tolerability of modern cytotoxic chemotherapy regimens used in malnourished metastatic colorectal cancer (mCRC) patients is uncertain. aim this study was to investigate the effect malnutrition on overall survival mCRC patients.In multicenter study, demographic, oncologic nutritional data were collected prospectively from patients. Nutritional status evaluated basis NRI (Nutritional Risk Assessment), BMI (Body Mass Index) WL (Weight Loss) before first chemotherapy, after...
Insulin-like growth factor-1 (IGF-1) and its primary binding protein-3 (IGFBP-3) play an important role in cellular proliferation, differentiation apoptosis many tumors, including breast cancer (BC). The objective of this study was to determine the clinical significance serum levels IGF-1 IGFBP-3 BC patients. A total 96 patients with a pathologically confirmed diagnosis were enrolled into study. Serum determined by solid-phase sandwich enzyme-linked immunosorbent assay (ELISA) methods. Age-...
Tenascin-C (TNC) is a key molecule in tissue remodeling, and high levels are observed many diseases, including heart failure, thrombosis, atherosclerosis, cancer. High TNC expression by immunohistochemical analysis has been shown invasive metastasizing tissues from variety of cancers, colon, lung, brain, breast. This study was conducted to investigate the serum level breast cancer patients its relationship with tumor progression known prognostic parameters. Ninety-six were enrolled into...
Transforming growth factor-beta1 (TGF-beta1) plays an important role in the pathogenesis of multiple malignancies, and also, its expression strongly affects outcomes cancer patients. The objective this study was to determine clinical significance serum levels TGF-beta1 gastric A total 63 patients with a pathologically confirmed diagnosis were enrolled into study. Serum concentrations determined by solid-phase sandwich ELISA method. Thirty healthy age- sex-matched controls included analysis....
Hepatocellular carcinoma (HCC) is one of the most aggressive cancer types. MicroRNAs (miRNAs) are small noncoding regulatory RNAs that function posttranscriptionally. miRNA deregulation was observed in development and progression HCC. In this study, we aimed to investigate expression levels four miRNAs (mir-33a, mir-203b, mir361-3p, mir-424) HCC patients comparison healthy individuals.Venous blood samples were collected from both individuals. order determine relative mir-33a, hsa-mir-424...
The prognosis of patients with advanced HCC can vary widely depending on factors such as the stage cancer, patient's overall health, and treatment regimens. This study aimed to investigate survival outcomes associated in hepatocellular carcinoma (HCC). In this retrospective study, data from 23 medical oncology clinics were analyzed. Progression-free (PFS) (OS) values estimated using Kaplan–Meier method. Prognostic which identified univariate analysis subsequently evaluated a multivariate...