A5053729961- Neuroendocrine Tumor Research Advances
- Nutrition and Health in Aging
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Glioma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Advanced Breast Cancer Therapies
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Frailty in Older Adults
- Rheumatoid Arthritis Research and Therapies
- Cancer survivorship and care
- Metastasis and carcinoma case studies
- COVID-19 and healthcare impacts
- Pancreatic and Hepatic Oncology Research
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Systemic Lupus Erythematosus Research
- Cancer Genomics and Diagnostics
- Coding theory and cryptography
- Cancer Treatment and Pharmacology
- Lung Cancer Diagnosis and Treatment
- Oral health in cancer treatment
Bezmiâlem Vakıf Üniversitesi
2021-2024
Marmara University
2016-2021
Bezmialem Foundation University Medical Faculty Hospital
2021
Geriatric syndromes may be more common in older cancer patients than those without cancer. can cause poor clinical outcomes. The Eastern Cooperative Oncology Group Performance Status (ECOG-PS) is often used as a clinically reported functional status score oncology practice.
In this Turkish Oncology Group study, we aimed to evaluate the effectiveness of trastuzumab emtansine (TDM1) in adjuvant treatment early-stage human epidermal growth factor receptor-2 (HER2)-positive breast cancer with residual disease using real-life data. A total 13 centers participated study between September 2019 and October 2024. Patients HER2-positive who underwent surgery after completing neoadjuvant chemotherapy HER2-targeted therapies had invasive or axillary lymph nodes received...
We aimed to identify a rapid, accurate, and accessible biomarker in the early stages of COVID-19 that can determine prognosis disease cancer patients.A total number 241 patients with solid cancers who had diagnosis between March 2020 February 2022 were included study. Factors ten different markers inflammation analyzed by year grouped severity infection.Hospitalization, referral intensive care unit (ICU), mechanical ventilation, death more frequent than 2021 (mortality rates, respectively,...
This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines treatment in patients with metastatic neuroendocrine tumors (NETs).
Aim: To assess the anxiety levels of breast cancer patients during COVID-19 pandemic. Materials & methods: A total 298 completed State-Trait Anxiety Inventory (STAI-S and STAI-T) Visual Analogue Scale for (VAS) VAS in (VAS-CoV). Results: 144 were high category STAI-S, 202 STAI-T. STAI-T score was significantly metastatic group (p = 0.017). VAS-CoV hormonotherapy higher than no-treatment 0.023). There a positive correlation between (r 0.708, p < 0.001), STAI-S scores 0.402, 0.001; r 0.185,...
Abstract Objective We aimed to evaluate cardiac safety profile of ribociclib with 24-h rhythm Holter ECG. Material and method Forty-two female metastatic breast cancer patients were included in the study. Rhythm ECG was performed before starting treatment after 3 months initiation. Results The mean age 56.36 ± 12.73. 52.4% ( n = 22) using combination fulvestrant 47.6% 20) aromatase inhibitors. None developed cardiotoxicity. When results third month compared, there no statistically...
Breast cancer is the most frequently diagnosed in women worldwide. Ribociclib now used treatment of metastatic hormone-positive and human epidermal growth factor receptor 2 (HER 2)-negative breast cancer.A 54-year-old woman with presented at a clinic November 2017 multiple lung bone metastases. After receiving lines due to disease progression, ribociclib fulvestrant were initiated. Grade 4 toxicity was observed during follow-up, discontinued permanently.Management & Outcome: Given that liver...
Although vaccination is efficacious and prevents infection in the general population, there limited data about Coronavirus disease-19 (Covid-19) occurrence after cancer patients. It was aimed to evaluate efficacy of BNT162b2 (Pfizer-BioNTech) CoronaVac vaccines against Covid-19 patients with cancer. In this single-center, retrospective, cross-sectional, descriptive study, referred medical oncology clinic a university hospital were analyzed. The sample study consisted who had or vaccinated...
Objective: To evaluate the predictive significance of systemic inflammation markers (SIMs) in patients with glioblastoma multiforme (GBM), who were treated bevacizumab (Beva).Study Design: Descriptive study.
Erlotinib, a tyrosine kinase inhibitor, has been shown to improve the survival of patients with epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer. Sarcopenia is status increasing importance in cancer, and it may predict poor prognosis. We aimed evaluate impact sarcopenia on erlotinib therapy prognosis EGFR-mutated (exon 19 or 21 L858R) metastatic adenocarcinoma. was defined as skeletal muscle index ≤39 cm2/m2 for women ≤55 men. The patient characteristics,...
Abstract Objective We aimed to evaluate cardiac safety profile of ribociclib with 24-hour-rhythm holter ECG. Material-Method: 42 female metastatic breast cancer patients were included in the study. Rhythm ECG was performed before starting treatment and after 3 months initiation. Results The mean age 56.36 ± 12.73. 52.4%(n = 22) using combination fulvestrant 47.6% (n 20) aromatase inhibitors.None developed cardiotoxicity. When rhythm results third month compared, there no statistically...
<title>Abstract</title> <bold>Objective</bold> We aim to determine the efficacy, and factors associated with effectiveness of first-line CDK4/6i (ribociclib or palbociclib) in HR-positive, HER2-negative MBC patients. <bold>Material method</bold> This is a retrospective, cross-sectional, descriptive study. Ninety patients metastatic breast cancer receiving CDK 4/6i from three different oncology clinics were included <bold>Results</bold> Of patients, 56 (62.2%) had received ribociclib, 34...
Aim: To compare anticholinergic burden (ACB) in older patients with and without cancer evaluate the effects of ACB on geriatric syndromes. Methods: A total 291 from clinic 301 oncology were evaluated. <2 was categorized as low ≥2 high ACB. comprehensive assessment performed clinic. Results: scores significantly higher compared those (p < 0.005). Number falls Geriatric Depression Scale 15 Mini-Nutritional Assessment Barthel/Lawton activities daily living lower Conclusion: It is crucial to...
Introduction: There is a lack of evidence the outcomes in elderly patients advanced stage biliary tract cancer due to aged over 65 years are less than 25% many prospective trials.We designed retrospective multicenter study evaluate factors affecting treatment and survival with advanced-stage cancer.Materials methods: A total 116 ≥65 were included, responses, survival, toxicity rates evaluated respect age groups Results: was no significant difference between response treatment, or...
Regorafenib, an oral multikinase inhibitor, has improved survival in metastatic colorectal cancer (mCRC) patients who have progressed on standard therapies. Our study aimed to evaluate prognostic factors influencing regorafenib treatment and assess the optimal dosing regimen a real-life setting. We retrospectively analysed 263 with mCRC from multiple medical oncology clinics Turkey. Treatment responses for were evaluated using univariate multivariate analysis. Of patients, 120 male, 143...
Tuba Baydas, Ganime Coban, Mehmet Besiroglu, Melih Simsek, Abdallah TM Shbair, Atakan Topcu, Ayse Irem Yasin, Mesut Seker, and Haci Turk. Int J Gastrointest Interv 2023;12:69-74. https://doi.org/10.18528/ijgii220012
Aim: To evaluate the relationship between anxiety and skeletal muscle index (SMI) levels in lung cancer patients on first day of chemotherapy. Materials & methods: This cross-sectional study included 108 patients. We analyzed patient characteristics, SMI levels, pain status predicted factors. Results: Anxiety was detected 61% were significantly lower high group than low (p < 0.001). A significant correlation observed (r = -0.292; p 0.002). correlated with trait 0.618; 0.001) visual analog...
Adrenocortical carcinoma (ACC) is an uncommon and aggressive tumor.Despite the current treatment options commonly used in ACC, prognosis poor.No risk factors have been identified except for genetic predisposition.The most important affecting are stage at time of diagnosis resectability primary tumor.Here, we present a metastatic ACC case 29year-old woman presented with symptoms swelling her feet, abdominal striae, mild pain three months.The computed tomography scan revealed 14 cm mass right...
Advanced-stage biliary tract cancers (BTC) are rare malignancies with poor prognosis. There few prospective trials, but several retrospective studies regarding treatment options. In this study, we aimed to investigate the role of systemic inflammatory parameters (SIP) and other possible independent factors that may affect survival approaches determine benefit later-line treatments in these patients.A total 284 patients, initially diagnosed advanced stage or progressed after curative BTC,...
Histopathological differentiation of primary lung cancer is clinically important. We aimed to investigate whether diffusion tensor imaging (DTI) parameters metastatic brain lesions could predict the histopathological types cancer.In total, 53 patients with 98 solid were included. Lung tumors subgrouped as non-small cell carcinoma (NSCLC) (n = 34) and small (SCLC) 19). Apparent coefficient (ADC) Fractional anisotropy (FA) values calculated from enhanced part metastases. The association...
Objective The aim of the study is to compare efficacy and safety 3 chemotherapy regimens used as first-line treatments in real-life management metastatic pancreatic cancer. Methods A total 218 patients were included this multicenter study. Gemcitabine (Gem, n = 71), gemcitabine-cisplatin (Gem-Cis, 91), FOLFIRINOX (a combination leucovorin, 5-fluorouracil, irinotecan, oxaliplatin [FFX], 56) compared. Results Overall response rate was significantly higher FFX group (50.0%) than Gem (28.2%)...