A5090565344- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Colorectal and Anal Carcinomas
- Renal cell carcinoma treatment
- Lung Cancer Treatments and Mutations
- Breast Lesions and Carcinomas
- Reproductive Biology and Fertility
- MRI in cancer diagnosis
- Inflammatory Biomarkers in Disease Prognosis
- Estrogen and related hormone effects
- Cancer Diagnosis and Treatment
- Cancer survivorship and care
- Gastric Cancer Management and Outcomes
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Ovarian function and disorders
- Bone health and treatments
- Vitamin D Research Studies
- Brain Metastases and Treatment
Memorial Sisli Hospital
2015-2023
Istanbul Aydın University
2019-2021
Ege University
2021
Pamukkale University
2021
City Hospital
2021
Haseki Eğitim ve Araştırma Hastanesi
2016-2020
Turkish Society of Hematology
2020
Istanbul Memorial Hospital
2019
Sağlık Bilimleri Üniversitesi
2018
Bahçeşehir University
2017
The correlation between imaging findings and pathologic characteristics of tumors may provide information for diagnosis treatment cancer. aim this study is to determine whether ultrasound features breast cancer are associated with molecular subtype, histologic grade, hormone receptor status, as well assess the predictive value these features.A total 201 consecutive invasive patients were reviewed from database according Breast Imaging Reporting Data System (BI-RADS). Tumor margins classified...
In this study, they investigated whether mean thrombocyte volume (MPV) and MPV/platelet count ratio have a prognostic significance in advanced NSCLC or not.A total of 496 patients at stage IIIB/IV did not meet exclusion criteria were included the study. The demographic features (age, gender, smoking habit), clinical characteristics (performance status, weight loss, disease stage, first-line treatment regimen), laboratory tests (levels hemoglobin, lactate dehydrogenase calcium as well MPV,...
The aim of this study was to evaluate the efficacy bioimpedance spectroscopy for follow-up patients with lymphedema in Turkey and its benefits diagnosis stage 0, 1, 2 who are under treatment breast cancer. Thirty-seven female cancer underwent surgical procedures our Breast Health Centre were followed up using bioimpedance, clinical measurements taken a minimum period 1 year at 3-month intervals. Patients had been monitored regularly between November, 2011, September, 2013, enrolled study. In...
The aim of the present study was to identify optimal Ki-67 cut-off value in breast cancer (BC) patients, and investigate association Ki‑67 expression levels with other prognostic factors. Firstly, a retrospective search performed patients stage I-III BC (n=462). A range index values were then assigned five groups (<10, 10-14, 15-19, 20-24 ≥25%). correlation between factors [age, tumor type, histological nuclear grade, size, multifocality, an situ component, lymphovascular invasion (LVI),...
Several prognostic factors have been studied in NSCLC, although it is unknown which most useful. In this study, we aimed to investigate whether pre-treatment serum albumin level has value patients with Stage IIIB NSCLC.This cross-sectional study included a total of 204 NSCLC who met the inclusion criteria. Pre-treatment levels and demographic, clinical, histological characteristics, as well laboratory variables were recorded. A cut-off was defined for stratified into four groups on thios...
Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer (BC) prevention. It also related to prognosis after diagnosis and treatment. The aim of our study was determine the prevalence vitamin as measured by serum 25-hydroxy (25-OHD) levels in patients with BC evaluate its correlations life-style treatments.This included 186 stage 0-III treated center between 2010-2013. correlation baseline 25-OHD supplement usage, age, menopausal status, diabetes...
We aimed to identify a rapid, accurate, and accessible biomarker in the early stages of COVID-19 that can determine prognosis disease cancer patients.A total number 241 patients with solid cancers who had diagnosis between March 2020 February 2022 were included study. Factors ten different markers inflammation analyzed by year grouped severity infection.Hospitalization, referral intensive care unit (ICU), mechanical ventilation, death more frequent than 2021 (mortality rates, respectively,...
One of the most important adverse effects zoledronic acid (ZA) is osteonecrosis jaw (ONJ). In previous literature, several risk factors have been identified in development ONJ. this study, we aimed to determine role trastuzumab, an antiangiogenic agent, as independent factor for serious side effect. Our study included 97 patients (mean age: 54 ± 10 years) with breast cancer, recorded archives Istanbul Florence Nightingale Breast Study Group, who received ZA therapy due bone metastases...
Background The Oncotype Dx recurrence score (ODx-RS) guides the adjuvant chemotherapy decision-making process for patients with early-stage hormone receptor-positive, HER-2 receptor-negative breast cancer. This study aimed to evaluate survival and its correlation ODx-RS in pT1-2, N0-N1mic treated therapy based on tumor board decisions. Patients methods Estrogen-positive negative cancer (pT1-2 N0, N1mic) known ODx-RS, operated between 2010 2014, were included this study. primary aim was...
The expression of epidermal growth factor receptor (EGFR) has been linked to clinical outcome in several solid tumors. However, the significance EGFR (c-erbB1) gastric cancer remains unclear. present study was designed detect implications Turkish population. Paraffin-embedded tissue microarrays containing were obtained from 30 patients. detected using immunohistochemistry. correlation this biomarker clinicopathological features and survival patients with studied. overall positivity rate...
Background: The phosphatidylinositol 3'-kinase/Akt (PI3K/Akt) pathway is a key regulator for HER2-overexpressing breast cancer, but data about whether activation of PI3K/Akt associated with poor prognosis and resistance to trastuzumab therapy controversial. In this study we investigated predictive prognostic significance expression p27, Akt, PTEN PI3K, which are components the signaling pathway, in HER2-positive metastatic cancer (MBC), retrospectively. Materials Methods: Fifty-four MBC...
Abstract Purpose The latissimus dorsi muscle has long been used in breast cancer (BC) patients for reconstruction. This study aimed to compare early stage BC who had partial mastectomy (PM) with mini flap (MLDF) and subcutaneous implant (MI) respect quality of life (QoL), cosmetic outcome (CO), survival rates. Patients methods data underwent PM + MLDF (Group 1) M I 2) between January 2010 2018 were evaluated. Both groups compared terms demographics, clinical pathological characteristics,...
The aim of this study is to evaluate the efficacy and toxicity trastuzumab emtansine (T-DM1) in cases with metastatic breast cancer (mBC) different lines treatment.Retrospective analysis T-DM1 results human epidermal growth factor receptor 2 (Her2) positive 414 mBC from 31 centers Turkey.Except 2, all were female a median age 47. had been used as second-line therapy 37.7% number cycles was 9. Progression-free survival (PFS) overall (OS) times according line treatment. OS found 43, 41, 46, 23...
This study was aimed at investigating clinical and histopathologic features of ipsilateral breast tumor recurrences (IBTR) their effects on survival after conservation therapy.1,400 patients who were treated between 1998 2007 had breast-conserving surgery (BCS) for early cancer (cT1-2/N0-1/M0) evaluated. Demographic pathologic parameters, radiologic data, treatment, follow-up related the recorded.53 (3.8%) IBTR BCS within a median 70 months. The mean age 45.7 years (range, 27-87 years), 22...
The aim of this study was to determine the roles biopsychosocial risk factors in development breast cancer.This hospital-based case-control included 491 women with cancer (study group) and 512 who did not have or other serious diseases (control group). Biological, psychological, social were compared between two groups. Data collected using semi-structured interview, Stress Assessment Form, Coping Strategy Indicator assess these factors.When significantly different variables control groups...
Premenopausal breast cancer with a triple-negative phenotype (TNBC) has been associated inferior locoregional recurrence free survival (LRFS) and overall (OS) after conserving surgery (BCS). The aim of this study is to analyze the association between age, subtype, surgical treatment on in young women (≤40 years) early population high rate women.Three hundred thirty-two patients ≤40 years old stage I-II invasive who underwent at single institution 1998 2012 were identified retrospectively....
Objective The aim of the present study was to investigate possibility effect life long stressful events, along with coping method used, perception social support, and style on development breast cancer. Methods In this hospital-based case control study, group comprised 250 women cancer who were followed by Florence Nightingale Breast Study Group. Control included women, had similar sociodemographic characteristics group. Data collected semi-structured interview form, Healthy Life Style...
To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological statuses of 201 MBC 1995 2015 retrospectively recorded. Survival analyses conducted uni- multivariate cox regression analysis.Median follow-up time was 54 (4-272) months. Median patient age at diagnosis 47 years old (26-90). Of patients, 91.5% triple negative. Five-year...