A5036745583- Breast Cancer Treatment Studies
- Breast Lesions and Carcinomas
- Advanced Radiotherapy Techniques
- Breast Implant and Reconstruction
- Endometrial and Cervical Cancer Treatments
- Brain Metastases and Treatment
- Cancer Diagnosis and Treatment
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Multiple and Secondary Primary Cancers
- Cancer Treatment and Pharmacology
- Lung Cancer Treatments and Mutations
- Advanced Breast Cancer Therapies
- Head and Neck Cancer Studies
- Medical Imaging Techniques and Applications
- Cervical Cancer and HPV Research
- Lung Cancer Research Studies
- BRCA gene mutations in cancer
- Colorectal and Anal Carcinomas
- Lanthanide and Transition Metal Complexes
- Radiation Therapy and Dosimetry
- Metabolism and Genetic Disorders
- HER2/EGFR in Cancer Research
- Lung Cancer Diagnosis and Treatment
- Radiation Dose and Imaging
Istanbul University
2016-2025
Radiation Oncology Institute
2018-2025
Npistanbul Brain Hospital
2021-2024
Radiation Oncology Associates
2021
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2018
Trakya University
2007-2014
Importance Increasing evidence supports the oncologic safety of de-escalating axillary surgery for patients with breast cancer after neoadjuvant chemotherapy (NAC). Objective To evaluate outcomes among clinically node (cN)–positive and whose disease became cN negative NAC (ycN negative). Design, Setting, Participants In NEOSENTITURK MF-1803 prospective cohort registry trial, from 37 centers cT1-4N1-3M0 treated sentinel lymph biopsy (SLNB) or targeted dissection (TAD) alone ypN-negative...
We aimed to evaluate retrospectively the correlation of loco-regional relapse (LRR) rate, distant metastasis (DM) disease free survival (DFS) and overall (OS) in a group breast cancer (BC) patients who are at intermediate risk for LRR (T1-2 tumor 1-3 positive axillary nodes) treated with or without postmastectomy radiotherapy (PMRT) following modified radical mastectomy (MRM).Ninety patients, T1-T2 tumor, nodes had undergone MRM received adjuvant systemic therapy (n = 66) 24) PMRT....
BACKGROUND:We compared pathological prognostic stage (PPS) with anatomic (AS) groups according to the updated version of breast cancer staging American Joint Committee on Cancer (AJCC) 8th Edition. MATERIAL AND METHODS:We evaluated 353 patients initially treated surgery. AS and PPS were performed by evaluating data AJCC Edition version. Stages survival rates between 2 systems compared. Disease-free (DFS) disease-specific (DSS) calculated both using Kaplan-Meier test. After change was made in...
Abstract Background: Previous prospective studies reported decreased false negative rates in patients presenting with T1-3/cN1 disease, the removal of 2 or more sentinel lymph nodes (SLNs), using combined technique for SLN biopsy (SLNB), and by targeted axillary dissection (TAD) initially clinically node-positive after neoadjuvant chemotherapy (NAC). The aim this study is to compare feasibility oncological safety TAD SLNB cN-positive/ycN0 breast cancer following NAC a study. Methods: This...
Objective To investigate the impact of cumulative cisplatin dose on clinical outcomes in locally advanced cervical cancer patients undergoing definitive chemoradiotherapy. Methods A retrospective analysis was conducted 654 with stage IB3–IVA disease treated Radiotherapy applied as external beam pelvic or without para-aortic radiotherapy and brachytherapy. Concomitant chemotherapy form weekly 3 cisplatin. Data demographics, treatment protocols, dose, adverse effects, survival were collected....
e17534 Background: This multicentric study aimed to investigate the impact of cumulative cisplatin dose on clinical outcomes in locally advanced cervical cancer patients undergoing definitive chemoradiotherapy (CRT). Methods: A retrospective analysis was conducted 654 with stage IB3-IVA disease treated CRT. Radiotherapy (RT) applied as external beam pelvic or without para-aortic RT and brachytherapy. Concomitant chemotherapy form weekly 3-weekly cisplatin. Data demographics, treatment...
Abstract Background The omission of axillary lymph node dissection (ALND) remains controversial for patients with residual disease after neoadjuvant chemotherapy (NAC), regardless the burden. This study evaluated oncologic safety and factors associated outcomes in disease. These were treated solely sentinel biopsy (SLNB) or targeted (TAD), without ALND, NAC. Methods A joint analysis two different multicenter cohorts—the retrospective cohort registry MF18‐02 prospective observational MF18‐03...
The assessment of immune infiltrate in invasive breast carcinomas (IBCs), most commonly referred to as tumor infiltrating lymphocytes (TILs), is gaining importance the current quest for optimal biomarker selection and prediction prognosis. In this study, impact intensity TILs expressions cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death-1 (PD-1), lymphocyte activation gene 3 (LAG-3) a group with regards prognosis conventional pathologic parameters was scrutinized....
The aim of this study was to determine the clinicopathological characteristics, treatment details and outcome patients with brain metastasis from epithelial ovarian carcinoma (EOC).This included 21 diagnosed EOC between 1999 2009.Median age 61 years (range 38-77). median time elapsed diagnosis detection 32 months. Single metastases were found in 10 (48%) cases, there extra-cranial disease 11 (52%) cases. During mean 86 months follow-up, 18 (86%) died 3 (14%) alive disease. survival after...
Introduction: Patients with HER2-positive metastatic breast cancer are at risk for developing brain metastases. Different anti-HER2 treatments can be used in the management of disease. In this study, we aimed to evaluate prognosis and factors affecting patients cancer. Methods: Clinical pathological features magnetic resonance imaging onset metastasis were recorded. Survival analyses performed using Kaplan-Meier Cox regression methods. Results: Analyses study by including 83 patients. The...
Abstract Aim Clinicopathologic,demographic characteristics, and treatment patterns of patients diagnosed with male breast cancer (MBC) treated adjuvant radiotherapy (RT) in the last 20 years were retrospectively analyzed. Material Method: Between January 2000 2021, 207 MBC, all whom underwent RT, recruited from 25 centers.Kaplan-Meier method was used to determine rates overall survival (OS),progression-free (PFS),and loco-regional recurrence-free survival(LRRFS).Multivariate Cox regression...
Abstract ABSTRACT Background Individualized treatment strategies are highlighted for breast cancer patients in the last decades. Therefore aggressive surgical approaches have begun to evolve towards minimally invasive tailored interventions. SLNB is widely used who received neoadjuvant (NAC) and axillary lymph node dissection (ALND) recommended with residual disease after NAC. In our study, we investigated regional recurrence rates limited NAC underwent imaging-guided (MR+USG) surgery plus...
<title>Abstract</title> Background Sentinel lymph node biopsy(SLNB) is widely used in patients who receive neoadjuvant chemotherapy(NAC). Still, axillary dissection(ALND) recommended for with any residual disease after NAC. The necessity of ALND minimal unclear. We aim to investigate regional recurrence rates limited NAC underwent SLNB + image-tailored surgery and adjuvant radiotherapy (RT). Methods Patients clinical stages were T1-3 N1 at the time diagnosis, clinically good or complete...