A5065482599- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal and Anal Carcinomas
- HER2/EGFR in Cancer Research
- Colorectal Cancer Surgical Treatments
- Cancer Genomics and Diagnostics
- Retinoids in leukemia and cellular processes
- Cancer Diagnosis and Treatment
- Colorectal Cancer Screening and Detection
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Prostate Cancer Treatment and Research
- Pancreatic and Hepatic Oncology Research
- Bone health and treatments
- Research in Cotton Cultivation
- Renal cell carcinoma treatment
- Cell death mechanisms and regulation
- Lung Cancer Treatments and Mutations
- Genetic factors in colorectal cancer
- Cancer, Lipids, and Metabolism
- PI3K/AKT/mTOR signaling in cancer
- Neuroendocrine Tumor Research Advances
- Cancer therapeutics and mechanisms
Ege University
2015-2024
Kent Hastanesi
2021-2024
Acıbadem Adana Hospital
2024
Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
2023
Afyon Kocatepe University
2023
Izmir University
2020-2023
Hacettepe University
2023
Marmara University
2023
Kent Hospital
2021-2022
Ege Üniversitesi Tıp Fakültesi Hastanesi
2014-2020
Abstract Background The optimal timing of surgery following preoperative chemoradiotherapy (CRT) is controversial. This trial aimed to compare pathological complete response (pCR) rates obtained after an interval 8 weeks or less versus more than weeks. Methods Patients with locally advanced rectal adenocarcinoma situated within 12 cm the anal verge (T3–4 N+ disease) were randomized undergo total mesorectal excision (TME) (classical interval, CI group) (long LI CRT. Results Among 327 included...
This study compared the two different commercially available in vitro viability assays: XTT and Alamar blue (AB), to detect anti-proliferative effects of AT-101, a cotton plant extract, on six human carcinoma cell lines including: prostate (PC-3 DU-145), breast (MCF-7 MDA-MB-231), ovary (OVCAR-3 MDAH 2774) time- dose-dependent manner. Cells were exposed AT-101 concentration range 2.5–40 µM for 24, 48, 72 h. The AB assay was slightly more sensitive than evaluation at 24 h, suggesting that...
The objective of this study was to prepare the microemulsion methotrexate (M-MTX) for oral use and investigate suppressive effect MTX-loaded on MCF-7 human breast cancer cells. At same time M-MTX compared with those a solution drug (Sol-MTX). Microemulsion composed soybean oil as phase, mixture Cremophore EL Span 80 surfactants, isopropyl alcohol co-surfactant, 0.2 N NaOH aqueous phase. MTX added into at last stage. We clearly demonstrated that had significant cytotoxic cell lines...
Abstract Docetaxel, a semi‐synthetic taxane analogue, is used effectively in the treatment of metastatic prostate cancer. Zoledronic acid, most potent member bisphosphonates, has shown pleiotropic anti‐tumoral effects on cancer cells. We have explored possible additive/synergistic and apoptotic pathways induced by combination docetaxel zoledronic acid hormone drug refractory, PC‐3 DU‐145 Combination synergistically inhibits cell growth Moreover, this effect was due to downregulation...
Purpose: We aimed to investigate the improvement in symptoms, quality of life, patient and family satisfaction with care, direct costs resulting from a palliative care program based case management model. Methods: The research was implemented at Medical Oncology Clinic hospital University between September 2009 2011. sample consisted total 44 patients (22 control 22 intervention group). tools were Edmonton Symptom Diagnosis System, Karnofsky Performance Scale, EORTCQLQ-C30 Quality Life form,...
There are only two prospective, randomized studies comparing preoperative long-term chemoradiotherapy and postoperative in locally advanced rectal cancer (LARC); however, conflicting results terms of locoregional recurrence (LR) survival rates have been reported. This prospective study aims to compare the effects versus on LARC patients. From January 2003 2016, a total 336 eligible patients who were clinically diagnosed with (T3–T4 tm or node-positive disease) prospectively assigned into (n...
TPS182 Background: Trastuzumab in combination with chemotherapy has been shown to prolong survival of HER2+ esophago-gastric cancer patients. The primary aim our study was evaluate safety and tolerability trastuzumab (T) oxaliplatine (O), capecitabine (C) radiation (R) therapy the adjuvant setting curatively resected Methods: Forty patients IB or higher stages planned be recruited here we report interim analyses on 22. We would consider positive if at least 64.4% could tolerate therapy....
Objective. Most patients with pancreatic cancer show an inoperable locally advanced/ metastatic tumour at the time of diagnosis. The present study was aimed determining prognostic factors in advanced carcinoma treated gemcitabine. Material and methods. Sixty-seven unresectable or gemcitabine were included a total 258 cycles treatment applied. Results. overall response rate 5%. Thirty-one percent had stable disease, whereas progressive disease seen 49%. Clinical benefit 15%. median duration...
In the present study, we aimed to evaluate possible synergistic, cytotoxic effects of combination treatment gossypol and zoledronic acid, in human ovarian cancer cell lines, OVCAR-3 MDAH-2774, elucidate role this novel on angiogenesis-related molecules cancer. The XTT viability assay was used for showing cytotoxicity. Both DNA fragmentation by ELISA caspase 3/7 activity measurement were demonstrating apoptosis. To angiogenic affected treatment, mRNA levels measured using Human Angiogenesis...
The management of hormone-refractory prostate cancer (HRPC) still remains as an important challenge daily oncology practice. Docetaxel has proved to be a first line treatment choice. All-trans retinoic acid (ATRA) could potently inhibit the growth cells in vitro and its combination with various anticancer agents results increased cytotoxicity. Based on these data, our aim was examine synergistic/additive cytotoxic apoptotic effects docetaxel ATRA, hormone- drug refractory human DU-145 cells....
A high-risk group of patients with stage II colon cancer has been identified by the results studies in Western populations. The aim this study was to investigate prognostic factors adjuvant chemotherapy Turkish cancer.A total 554 were retrospectively enrolled study. Three hundred fifty-three had received (5-FU-LV, FOLFOX or FLOX) and 201 no chemotherapy. T4 tumor stage, lymphovascular invasion, perineural bowel obstruction and/or perforation, <12 harvested lymph nodes, poor differentiation...
Background: Trastuzumab prolonged the overall survival in patients with advanced gastric cancer human epidermal growth factor receptor 2 (HER2) overexpression combination chemotherapy. In this phase II open-label prospective study, tolerability and safety of trastuzumab chemotherapy, chemoradiotherapy for curatively resected HER2-positive carcinoma was investigated. Methods: The gastric, or gastroesophageal junction adenocarcinoma, after gastrectomy plus D2 dissection, were included. They...
Previous findings showed that paclitaxel induces interleukin-8 (IL-8) transcription and secretion in ovarian cancer cells vitro. We hypothesized treatment, which is a standard care for patients, may increase the of IL-8, resulting elevated serum IL-8 levels. In this study, we investigated relationship between exposure levels an breast carcinoma cell line vitro serums patients with carcinoma. Both MDAH 2774 MCF-7 lines were sensitive to paclitaxel-mediated cytotoxicity. However, supernatant...
Ovarian cancer is the most fatal gynecologic malignancies in world. Although, platinum based treatments are widely used, disease becomes treatment refractory within two years, and novel options should be searched. All- trans retinoic acid (ATRA) induces growth arrest, differentiation cell death some types of cells its combination with various anticancer agents results enhanced cytotoxicity. Zoledronic a common bisphosphonate known for effects beyond current use cancer-induced bone disease....
Inflammatory breast cancer (IBC) has an unfavourable prognosis despite the advances made in treatment of cancer. Our study aimed to define immunohistochemistry-based surrogate subtype distribution determine whether accompanied survival outcome differences IBC.Medical records female patients with non-metastatic inflammatory admitted our clinic between March 2000 and December 2015 were retrospectively reviewed. Patient demographics, clinical pathological feature primary tumour, adjuvant...