A5015596191- Lung Cancer Treatments and Mutations
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Advanced Breast Cancer Therapies
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Brain Metastases and Treatment
- Metastasis and carcinoma case studies
- Colorectal Cancer Treatments and Studies
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Sarcoma Diagnosis and Treatment
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Surgical Treatments
- Neutropenia and Cancer Infections
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cancer Risks and Factors
- Palliative Care and End-of-Life Issues
- Multiple and Secondary Primary Cancers
Pamukkale University
2016-2025
İzmir Tınaztepe Üniversitesi
2024
Kent Hastanesi
2024
Denizli Devlet Hastanesi
2013
Marmara University
2011
Erciyes University
2011
Istanbul Bilim University
2011
Akdeniz University
2011
Istanbul University
2011
Dokuz Eylül University
2004-2006
There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which oncologists prefer patients with disease progression under CDKi. In addition, we show the effectiveness of systemic treatments CDKi and whether there a survival difference between hormonal (monotherapy vs. mTOR-based).A total 609 from 53 centers were included study....
We know that detection of EGFR mutations is very important for individual therapy. Nowadays FFPE samples are commonly using to detect the mutation status. But it has a few handicaps such as, tumor heterogeneity and non-repeatable, need examine statues after each treatment regimen individually NSCLC patients. Therefore, there still develop non-invasive useable over again approach monitoring other genes So, we aim whether exosomes good target status or not. Pyrosequencing was used detect, in...
Abstract Epithelial ovarian cancer (EOC) is the second leading cause of death among women with gynecological cancers, particularly in high-income countries. Despite significant advancements molecular oncology and an initially positive response to primary chemotherapy, development drug resistance remains a major challenge effective management EOC. Consequently, there urgent need for innovative biological markers that can enable early diagnosis provide more accurate predictions recurrence risk...
Breast and cervical cancer are the most common causes of mortality among women worldwide, but actually they largely preventable diseases. There is limited data on breast knowledge, screening practices attitudes nurses in Turkey. A self-administered questionnaire was used to investigate knowledge attitude risk factors as well programmes such self-examination (BSE), clinical examination, mammography (MMG) papanicolaou (pap) smear test. In total, 125 out 160 participated study (overall response...
Cancer cachexia is one of the most frequent effects malignancy, often associated with poor prognosis, and may account for up to 20% cancer deaths. The aim our study was evaluate relationship serum levels resistin leptin in patients advanced non-small cell lung cancer.A total 67 chemotherapy-naïve advanced-stage a control group containing 20 healthy individuals without known chronic disease were enrolled this study. All age sex matched. Demographic, anthropometric, laboratory data adipokines...
Ribociclib, palbociclib and abemaciclib are currently approved CDK4/6 inhibitors along with aromatase as the first-line standard-of-care for patients hormone receptor-positive, HER2-negative metastatic breast cancer.
The cardiac toxicity of LV5FU2 (de Gramont) regimen which is a widely used chemotherapy in gastrointestinal system cancers not well defined. We aimed to evaluate the impact this on rhythm. Two Holter ECG recordings were obtained all patients with treated as first-line (one before and second during first 24 h chemotherapy). Records reviewed for heart rate, rhythm, atrial premature complexes (APC), ventricular (VPC), grades according Lown-Wolf grading ST segment changes. evaluated 27 patients....
This study aimed to determine the epidemiological characteristics of colorectal cancer in Turkey.In this multicenter, prospective, and cross-sectional registry study, data for 968 patients with from 21 centers 7 geographic regions were analyzed.Diagnosis was colon 662 (68.4%) rectum 306 (31.6%) patients. In total, 60.9% male; mean age 58.9±12.6 years. Among patients, 15.0% drinking alcohol, 17.5% smoking, 1.5% had familial history polyposis, diabetes mellitus, 1.0% inflammatory bowel...
Primary mesenchymal tumors of the colon are extremely rare among soft tissue sarcomas. These more aggressive and have poorer prognosis than adenocarcinoma colon. Here, we presented 3 cases primary Their histopathological diagnoses leiomyosarcoma, pleomorphic liposarcoma, desmoplastic small round cell tumor, respectively. The rarity makes it difficult to approach treatment predict these tumors.
The angiotensin-converting enzyme (ACE) plays an important role not only in the regulation of vascular homeostasis but also stimulation hematopoiesis. We aimed to evaluate association between insertion/deletion (I/D) polymorphism ACE gene and anemia at time diagnosis. enrolled 75 patients with non–small-cell lung cancer (NSCLC) 85 age- sex-matched healthy control participants. I/D was identified by using polymerase chain reaction from peripheral blood samples. Statistical analyses were...
In this study, we aimed to determine the personal, social and economic burden frequency of depression, as well in caregivers cancer patients who are being treated with chemotherapy Turkey. The study is designed a cross-sectional survey using 5-point Likert-type response scale, last part questionnaire includes Beck Depression Inventory. depression rate was found be 64% (n = 476) among all subjects 968), 91% those demonstrating signs mild depression. significant difference between presence age...
Advanced bladder cancer (BC) is associated with an inflammatory nature and poor prognosis Inflammatory biomarkers are potential predictors in BC. We conducted a study to assess the prognostic value of pretreatment neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR) advanced cancer.A total 226-patients muscle-invasive BC (MIBC) were included. Overall (OS) progression-free survival estimated using Kaplan-Meier method log-rank test was used for...
In non-small-cell lung cancer (NSCLC), stage of the disease is still most important prognostic factor. Other than stage, many biological markers and other factors are studied to define their effects on prognosis cancer. this study, we aimed evaluate expressions Bax bcl-2 genes which in apoptosis c-kit, a tyrosine kinase transmembrane receptor, as well searched response treatment modalities survival. Sixty-nine NSCLC cases' pathological samples were stained with specific Bax, c-kit dyes by...
The aims of the present study were to investigate distribution insertion/deletion (I/D) polymorphism angiotensin-converting enzyme (ACE) gene in breast cancer patients and association between ACE genotypes clinicopathologic features, as well their effects on prognosis. We assessed I/D polymophism by using polymerase chain reaction from peripheral blood healthy age-matched women. parameters obtained medical records. Of 57 patients, 31 (54.4%) had DD, 24 (42.1%) ID, 2 (3.5%) II genotypes. In...
Tumor lysis syndrome is a potentially fatal complication of anticancer therapy that usually seen in patients with bulky, rapidly proliferating, treatment-sensitive tumors such as hematological malignancies, but it rarely occurs variety solid colorectal carcinoma. Combination chemotherapy infusional 5-fluorouracil/leucoverin and irinotecan has been recently accepted the first treatment option for metastatic cancer. We present case tumor patient colon carcinoma occurred 72 hrs after initial...
The association between the polymorphism of angiotensin-converting enzyme (ACE) gene and breast cancer risk has been extensively studied, however, studies about prognostic factors ACE are limited in number. Our aims were to analyze distribution insertion/deletion (I/D) Turkish premenopausal patients with cancer, which is more aggressive than postmenopausal counterpart, assess whether DD genotype associated poor factors. shown be increased serum tissue levels ACE, compared those II ID...
P63 is a gene located in chromosome 3q27-29, which has been implicated regulation of stem cell commitment and promotion squamous differentiation various tissues. The aim this study was to investigate whether there correlation between p63 expression, differential diagnosis lung carcinoma, prognosis.Immunohistochemical expression 62 carcinomas investigated mRNA analysis using RT-PCR method done 6 selected cases.When cases were evaluated for staining, 24 25 (96%) strongly positive. Six 20...
Objective This study aimed to evaluate the efficacy and safety profile of capecitabine oxaliplatin (CAPOX) 5-fluorouracil, leucovorin, (FOLFOX) regimens as adjuvant treatment in patients with stage III colon cancer. Methods A total 243 who received CAPOX FOLFOX chemotherapy between 2014 2018 for cancer two centers were retrospectively studied. Among patients, 106 (43.6%) 137 (56.4%) treated using regimens, respectively. Efficacy, treatment-related side effects, overall survival rates these...
Real-world (RW) data provide valuable information about the effectiveness and safety of treatment modalities in general population that is not limited by selection criteria clinical studies. The aim this study was to evaluate palbociclib or ribociclib plus fulvestrant hormone receptor-positive human epidermal factor 2-negative metastatic breast cancer (HR+/HER2-MBC). We conducted a multicenter, retrospective cohort included 522 patients with HR+/HER2-MBC treated combination fulvestrant....