A5091450173- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cancer-related Molecular Pathways
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Breast Cancer Treatment Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cervical Cancer and HPV Research
- Chronic Lymphocytic Leukemia Research
- Genetic factors in colorectal cancer
- Advanced Breast Cancer Therapies
- Frailty in Older Adults
- Lung Cancer Research Studies
- Cancer survivorship and care
- Colorectal and Anal Carcinomas
- Endometrial and Cervical Cancer Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Statistical Methods and Inference
- Metastasis and carcinoma case studies
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Digital Media Forensic Detection
Gülhane Askerî Tıp Akademisi
2024
Mustafa Kemal University
2018-2023
Necmettin Erbakan University
2023
Ankara University
2013-2023
Dicle University
2014-2023
Creative Commons
2023
Akdeniz University
2023
Rize Devlet Hastanesi
2023
Tokat Gaziosmanpaşa Üniversitesi
2021
There is no standard treatment recommended at category 1 level in international guidelines for subsequent therapy after cyclin-dependent kinase 4/6 inhibitor (CDK4/6) based therapy. We aimed to evaluate which oncologists prefer patients with disease progression under CDKi. In addition, we show the effectiveness of systemic treatments CDKi and whether there a survival difference between hormonal (monotherapy vs. mTOR-based).A total 609 from 53 centers were included study....
Colorectal carcinomas are the third-most common tumors in world, and colorectal cancer ranks second cancer-related deaths. Our aim this study was to investigate correlation between programmed cell death ligand 1 (PD-L1) expression clinicopathologic parameters their relationship tumor immune microenvironment, epithelial-mesenchymal transition (EMT), microsatellite instability. We also investigated predictive prognostic role of PD-L1.One hundred patients with a diagnosis adenocarcinoma who did...
The predictive value of different prognostic biomarkers has been studied in various cancer types.The purpose this study was to examine the degree risk and significance pretreatment neutrophil-to-lymphocyte ratio (NLR) carbohydrate antigen (CA) 19-9 levels patients with metastatic pancreatic (PC) reveal its relevance survival.Clinical laboratory data 118 PC at time diagnosis were retrospectively analyzed. overall survival (OS) estimated according Kaplan-Meier method. To determine factors...
Gastric cancer is one of the most common types cancer.However, despite a significant decrease in incidence this over past two decades, it remains leading cause cancer-related deaths worldwide. 1Improved treatment strategies are, therefore, necessary as prognosis for these patients poor.Gastric frequently diagnosed at an advanced stage due to lack specific, early symptoms associated with disease.The low screening rates Türkiye, where gastric not included program, another reason its late...
Identification of biomarkers used for the prognostic evaluation non-small cell lung cancer (NSCLC) patients is important. The aim this study was to evaluate potential value XRCC1, ERCC1, ERCC2, and TP53 single nucleotide polymorphisms (SNPs) in completely resected NSCLC patients. In total, 130 patients, surgically treated between 2000 2012, were included. An analysis SNPs from peripheral blood cells performed by polymerase chain reaction. XRCC1 Arg399Gln, ERCC1 Asn118Asn, ERCC2 Lys751Gln,...
Random Forest (RF), a mostly model-free and robust machine learning method, has been successfully applied to right-censored survival data, under the name of Survival (RSF). However, RF/RSF its distinct strategies in classification prediction. First, it is an ensemble classifier performance average multiple rounds data fitting. Second, training set bootstrap (sampling with replacement) generated repeated used roughly 2/3 all samples testing consists those not (out bag samples). Both features...
Thyroid hormones increase the hepatic glyconeogenesis, glycogenolysis and absorption of glucose. Glucose intolerance is common in thyroid dysfunction. HbA1c most important determinant long term glysemic status diabetic patients. affected from various factors. In this study we evaluated relation between function tests non-diabetic patients with Non-diabetic 43 hyperthyroidism, 20 hypothyroidism for control group 29 euthyroid which appealed to Ankara Numune Training Research Hospital Internal...
e11511 Background: Carcinoembryonic antigen (CEA) and carbohydrate (CA) 15-3 are frequently elevated in patients with metastatic breast cancer (MBC). In this study we aimed to correlate levels according cancersubtypes MBC. Methods: From January 2008 December 2012, ninety-eight MBC who were treated at Ankara University School Of Medicine, Department of Medical Onkology included study.Serum CEA CA 15-3were measured compared tumor estrogen receptor (ER), progesteron (PR), human epidermal growth...
ÖZET GİRİŞ ve AMAÇ: Meme kanseri hastalarına ait heterojen yaşam verilerinin modellenmesi sağkalım süresini etkileyen faktörlerin belirlenmesi
e15602 Background: Most of the randomizedstudies that have evaluated clinical outcome anti-VEGF treatment in metastatic renal cell carcinoma (RCC) were focused mostly on clear histology. Non-clear RCC excluded or represented by a small number patients pivotal studies. In this study, our aim is to determine benefit and toxicity sunitinib non-clear patients. Methods: A total 63 who complete data from 13 oncology centers retrospectively evaluated. Treatment response, toxicity, progression free...
Giriş: Bu çalışmada amaç pankreas kanseri tanısı alan olguların klinik özelliklerinin ve risk faktörleri ile ilişkisinin retrospektif olarak değerlendirilmesi pankreatik kanserli hastaların yaşam süresini etkileyen prognostik faktörlerin araştırılmasıdır.Materyal Metot: Çalışmada almış 144 hastanın demografik özellikleri incelendi. Demografik özelliklerin sağkalım ilişkisini incelemek için istatistiksel analizler yapıldı. İstatistiksel SPSS (version 21; IBM, Armonk, NY) paket programı...
The aim of this study was to investigate the relationship between tumor budding (TB) and clinicopathologic prognostic criteria in colorectal adenocarcinomas discuss inclusion fourth group scoring system. A total 131 cases were included study. TB scored according classical 3‐tiered system our proposed 4‐tiered system: BD0 (no buds), BD1* (1–4 BD2 (5–9 BD3 (≥10 buds). Cytokeratin staining applied 80 randomly selected re‐evaluated. not observed 31 (23.7%) categorized as BD0. Patients with had...
e19109 Background: DNA repair pathway genes are associated with lung cancer development. The aim of this study was to evaluate the association XRCC1, ERCC1, ERCC2 and, TP53 SNPs stage at diagnosis in NSCLC patients. Methods: In total 275 patients, who had been treated for between 2000 and 2012, were included study. Analysis from peripheral blood cells performed by polymerase chain reaction. XRCC1 Arg399Gln, ERCC1 Asn118Asn, Lys751Gln Arg72Pro polymorphisms evaluated conjunction clinical...
Giriş ve Amaç: Bu çalışmanın amacı, kan grupları ile mide kanseri riski arasındaki ilişkiyi araştırmaktır. Gereç Yöntem: Çok merkezli, gözlemsel, vaka-kontrol çalışmasına 2000-2016 yılları arasında tanısı takip edilen serolojik olarak ABO grubu belli olan hastalar dahil edildi. Kontrol ise Türk Kızılayı’na bağışında bulunan sağlıklı kişiler seçildi kişilerin gruplarına Kızılayı’nın kayıtlarından ulaşıldı. İstatistiksel analizler için SPSS versiyon 13 kullanıldı. Bulgular: Mide grup kontrol...
Studies on single nucleotide polymorphisms (SNPs) in non-small cell lung cancer (NSCLC) suggest that DNA repair capacity may have prognostic implications for disease recurrence and survival. However, there is no study investigating the relationship between SNPs risk of metastasis at time initial diagnosis patients with NSCLC.This aimed to investigate potential predictive value detecting poor prognosis NSCLC.In this prospective cohort study, we evaluated 275 NSCLC. Analysis from peripheral...
e18521 Background: Identification of biomarkers that can be used for the prognostic evaluation NSCLC patients is important. The aim this study was to evaluate potential value XRCC1, ERCC1, ERCC2 and, TP53 SNPs in completely resected patients. Methods: In total 130 patients, who had been surgically treated between 2000 and 2012, were included study. Analysis from peripheral blood cells performed by polymerase chain reaction. XRCC1 Arg399Gln, ERCC1 Asn118Asn, Lys751Gln Arg72Pro polymorphisms...
e16212 Background: The aim of this study is to investigate whether Prognostic Nutritional Index (PNI), which an inflammation based prognostic index, associated with survival in metastatic pancreatic cancer patients. Methods: A total 221 adenocarcinoma patients were recruited between 01/ 2010 and 2013. PNI was calculated as (10 x serum albumin [g/dL]) + (0.005 peripheral lymphocyte count [per mm3]). Independent prognosticators tested on Cox regression analysis. Results: Median age 61(31-85)...