A5061917722- Virus-based gene therapy research
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Angiogenesis and VEGF in Cancer
- Turkey's Politics and Society
- CAR-T cell therapy research
- Circadian rhythm and melatonin
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Lung Cancer Treatments and Mutations
- Metastasis and carcinoma case studies
- Neutropenia and Cancer Infections
- Lung Cancer Research Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Blood groups and transfusion
- Cancer Genomics and Diagnostics
- Radiopharmaceutical Chemistry and Applications
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
Ankara University
2015-2024
Rheinland-Pfälzische Technische Universität Kaiserslautern-Landau
2024
University of Kaiserslautern
2021-2023
Creative Commons
2022
Ankara Numune Eğitim ve Araştırma Hastanesi
2004-2018
Austrian Institute for International Affairs
2017
Inonu University
2013
Erciyes University
2007-2012
Marmara University
2006-2011
Istanbul University
2011
The COVID-19 pandemic affected health care systems globally and resulted in the interruption of usual many facilities, exposing vulnerable patients with cancer to significant risks. Our study aimed evaluate impact this on worldwide.
Abstract Background In this non‐randomized study we aimed to assess the efficacy of addition low molecular weight heparin (LMWH) gemcitabine (GEM) plus cisplatinum (CDDP) combination chemotherapy on survival by prevention thromboembolic complications in patients with advanced pancreatic cancer (APC). Patients and Methods Between November 1999 February 2004, 69 consecutive APC were treated GEM (800 mg/m 2 , day 1, 8) CDDP (35 every 21 days ±LMWH (nadroparine calcium, 2,850 IU/day until...
Although hepatitis B virus (HBV) reactivation in HBV carriers undergoing immunosuppressive therapy is clearly documented, the role of antiviral prophylaxis such individuals still controversial. The aim this study was to determine efficacy lamivudine with haemato/oncological malignancies, who receive chemotherapy. Eighteen malignancy, were candidates for chemotherapy, enrolled. Eight subjects (three leukaemia, four lymphoma and one multiple myeloma) enrolled prophylactic therapy. remaining 10...
To develop a method to overcome the anergy that exists in tumor hosts cancer, we have designed an adenoviral vector for vivo activation and antigen loading of dendritic cells. This encodes fusion protein composed amino-terminal tumor-associated fragment fused CD40 ligand (CD40L). Subcutaneous injection encoding human papillomavirus E7 foreign linked CD40L generates CD8 + T cell-dependent immunoresistance growth E7-positive syngeneic TC-1 cancer cells C57BL/6 mice up 1 year. We also studied...
This study aimed to determine the epidemiological characteristics of colorectal cancer in Turkey.In this multicenter, prospective, and cross-sectional registry study, data for 968 patients with from 21 centers 7 geographic regions were analyzed.Diagnosis was colon 662 (68.4%) rectum 306 (31.6%) patients. In total, 60.9% male; mean age 58.9±12.6 years. Among patients, 15.0% drinking alcohol, 17.5% smoking, 1.5% had familial history polyposis, diabetes mellitus, 1.0% inflammatory bowel...
Previous studies have observed an association between ABO blood group and risk for certain gastrointestinal malignancies, including pancreatic gastric cancer. However, it is unclear whether there such with colorectal cancer (CRC). In this study, possible relationships groups Rh factor KRAS status in patients CRC were investigated.In 1,620 CRC, examined compared the control of 3,022,883 healthy volunteer donors Turkish Red Crescent 2004 2011. The relationship wild type K-ras was also...
We have previously demonstrated that a truncated form of the L-plastin promoter can confer tumor-specific patterns expression on replication-incompetent adenoviral vector reporter and therapeutic transcription units. In this report, 2.5-kb version was placed 5′ to E1A gene wild-type adenovirus. The generated (Ad-Lp-E1A) directly cytotoxic established breast ovarian cancer cell lines primary explant cultures derived from cancer, but not normal mammary epithelial cells. This in which unit...
Alveolar adenoma is a rare and benign tumour of the lung that usually presents in asymptomatic patients as coin lesion on chest radiography. Only 25 cases have been reported English medical literature. has characteristic multicystic histology often resembles normal parenchyma. Ultrastructural studies indicate epithelial cells lining cysts are type‐II pneumocytes. Immunohistochemical analysis may aid characterization alveolar discriminate this condition from other types lesions lung. An...
<i>Background:</i> The free radical theory of aging suggests the oxygen-derived species as causative agents and scavengers defense systems in process. exact role scavenging effects melatonin remains to be clarified. <i>Objective: </i>In this experimental study, we investigated age-related changes malondialdehyde (MDA), a lipid peroxidation product, glutathione (GSH) exogenous melatonin. <i>Methods: </i>Plasma, liver, lung MDA GSH levels 9- 28-month-old...
The pineal gland with its effects on immune system and free radicals may have a role aging process. In this study, we investigated the of melatonin (10 mg/kg/d, s.c. for 7 days), main secretion gland, humoral responses aged young male Wistar rats. Eighteen (28 months old; 6 in control group 12 group) 25 (9 10 15 rats were given 4×108 sheep erythrocytes i.p. order to evoke responses. After booster injection at end period three-weeks following last injection, IgM IgG1 levels measured....
Despite antiproliferative effects of melatonin on cultured tumor cells, its normal cells are less clear. The action telomerase activity in ageing gastric mucosal tissues also is not known. In this study, we investigated the age-related changes and cellular proliferation rate mucosa effect melatonin. A total 37 young (4 months old), aged (20 old) Wistar rats, kept under equal periods light dark, were divided into control [(PBS), i.p. for 21 days] melatonin-treated (10 mg/kg melatonin, days)...