Melatonin is a main neurohormone of the pineal gland. The effects melatonin on level serum thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), nitrate, and liver superoxide dismutase (SOD) activity were examined in rats. was injected at dose 10 mg/kg for 7 days, 2 h before turning lights off. Rats decapitated 10:00 a.m. 02:00 a.m., which are times lowest highest levels, respectively. Blood tissue samples collected. Decreased TSH, T3, T4 nitrate levels determined...

Ischemia–reperfusion (I/R) injury induces the generation of reactive oxygen species (ROS) which affect many organs. This study was designed to investigate roles melatonin and 1,25-dihydroxyvitamin D3 (VD3) on renal I/R injury. Thirty male Wistar albino rats were divided into five groups: group 1, control; 2, right nephrectomy (RN) + in contralateral kidney; 3, RN I/R; 4, VD3 5, I/R. Melatonin (10 mg/kg), (0.5 μg/kg), plus injected intraperitoneally for 7 days before After days, initially...

Nitric oxide is synthesized from L-arginine by endothelial nitric synthase encoded eNOS gene. This study was performed to investigate the relationship between serum level and gene polymorphism in Turkish population with angiographically diagnosed coronary artery disease (63.47 +/- 9.10 years old, n=250) control subjects without any history and/or risk factors of (60.71 9.14 n=150). Griess assay PCR-RFLP analysis were used measure metabolites genotypes, respectively. It found that Glu/Glu,...

Thrombopoietin (TPO), which is the main regulator of megakaryo/thrombopoiesis, has been recently cloned and purified, shown to be useful in discriminating thrombocytopenia due decreased production or increased platelet destruction. However, there are no detailed investigations about drug effects on TPO levels during childhood. This study was conducted measure children with immune thrombocytopenic purpura (ITP) steroid immunoglobulin treatment. Twelve patients acute ITP were treated high-dose...

This study was designed to evaluate the preventive role of melatonin (Mel) and 1,25-dihydroxyvitamin D3 (VD3) in biochemical apoptotic events leading tissue injury renal dysfunction after ischemia–reperfusion (I/R). Thirty male Wistar rats were divided into five groups: sham-operated, I/R, Mel + VD3 I/R. The intraperitoneally administered with (10 mg/kg), (0.5 μg/kg), or mg/kg) plus μg/kg) each day at 1 week prior ischemia. Right nephrectomy initially performed left I/R induced by 45 min...

We investigated the protective effect of vitamin D against liver damage caused by carbon tetrachloride (CCl4). Twenty-four male rats were divided into four equal groups: G1, untreated controls; G2, administered CCl4; G3, both CCl4 and for 10 weeks; G4, weeks 12 weeks. At end experiment, intracardiac blood samples taken removed. Hepatic due to was assessed using biochemistry histopathology. Glutathione (GSH) levels decreased, while malondialdehyde (MDA) increased in tissues G2. Alanine...

Vitamin D regulates calcium and phosphorus metabolism, it is essential for bone formation. Several factors can affect vitamin levels in plasma. In present study we compare of outpatients, who admit to Maltepe University Hospital between 2011 2013 had measurements regarding gender, age, season.

Objective: Our study aimed to determine the relationship between prevalence of vitamin D deficiency and calcium phosphorus levels by retrospectively obtaining D, calcium, values.Methods: Vitamin patients admitted family medicine

Neonatal sepsis is a major problem in newborn nurseries because of the difficulty early diagnosis and high morbidity mortality. The objective present study was to investigate whether urinary nitric oxide (NO) levels could be useful for infected newborns.Newborns with suspected infection according previously defined criteria between ages 1-7 days 8-30 were included as groups (p) compared age-matched healthy controls (c). Urine NO assayed by Sievers NOA based on chemiluminescence expressed...

The role of the immune system in patients with psoriasis vulgaris (PV) was investigated. genetic and immunological basis for is still unknown. Because reports defects this disease, we investigated serum levels immunoglobulins IgG, IgM, IgA, complement proteins C3, C4, zinc (Zn) natural killer (NK) cell activities. Skin lesions psoriatic involved study comprised less than 10 % total body disease a stationary period. Zn were measured by atomic absorption spectrophotometry. NK activity 51Cr...

Abstract Melatonin (MEL) is the main neuro‐hormone of pineal gland. The physiological function MEL to modulate variations light‐dark cycle and seasonal periodicity on various functions. Zinc (Zn) required as a catalytic component for more than 200 enzymes structural constituent many proteins, hormones, neuropeptides, receptors. In addition, tissue Zn levels have been found be altered after pinealectomy in rats. Recent findings shown that can turnover. present study, we investigated effect...

The medial olivocochlear efferent (MOCE) branch synapses with outer hair cells (OHCs), and the pathway can be activated via a contralateral acoustic stimulus (CAS). activation of MOCE change OHC motile responses convert signals that are capable controlling sensitivity peripheral hearing system in frequency-specific manner. aim this study was to examine activity professional musicians using transient evoked otoacoustic emission test CAS. Musician group showed stronger suppression all...

Abstract Melatonin (MEL) is the main neurohormone of pineal gland. Zinc (Zn) an essential trace element that required as a catalytic component for more than 200 enzymes. Both MEL and Zn are considered beneficial anti‐immunosenescence. Recent findings have shown can modulate turnover. The aim this study was to investigate effect treatment on tissue levels in young (4 months) middle‐aged (14 rats. Male wistar rats received during 3 weeks subcutaneous injection (10 mg/kg). After weeks, were...