Recurrent aphthous ulcer (RAU) is an inflammatory condition of the oral mucosa characterized by painful, well-circumscribed, single or multiple round ovoid ulcerations. The exact etiologic factor(s) these ulcerations are not yet understood. objective this study was to evaluate processes and free radical metabolism 25 patients with RAUs compared healthy controls. levels malondialdehyde (MDA) glutathione (GSH) were determined high-performance liquid chromatography. Tumor necrosis factor-alpha...

The coronavirus pandemic and subsequent protectionary lockdowns have negatively impacted farmers, especially those producing perishable agricultural products worldwide Türkiye. For this reason, most researchers began to investigate the effects of restrictions on agrarian branches during sudden shocks pandemic. This study was carried out reveal farmers’ desire for change in production period when were implemented A survey conducted with broad participation telephone interviews involving 2125...

Epileptic seizure results from excessive discharge in a population of hyperexcitable neurons. A number studies help to document the effects active oxygen free radical scavengers such as alpha-tocopherol or ascorbic acid (vitamin C). In present study, we examined acid, at six different doses, on penicillin-induced epileptiform activity.A single microinjection penicillin (2.5 microl, 500 units, intracortically) into left sensorimotor cortex induced activity within 2-5 min, progressing full...

Melatonin is a main neurohormone of the pineal gland. The effects melatonin on level serum thyroid-stimulating hormone (TSH), thyroxine (T4), triiodothyronine (T3), nitrate, and liver superoxide dismutase (SOD) activity were examined in rats. was injected at dose 10 mg/kg for 7 days, 2 h before turning lights off. Rats decapitated 10:00 a.m. 02:00 a.m., which are times lowest highest levels, respectively. Blood tissue samples collected. Decreased TSH, T3, T4 nitrate levels determined...

The reasons that cause delay in wound healing diabetes are a decrease the level of growth factors secretion, an increase destruction and oxidative stress. Platelet derived factor (PDGF) is one important play role all phases healing. This study investigates time-dependent effects topically PDGF-BB administration on events dorsolateral-excisional wounds diabetic rats. Forty-two female Wistar-albino rats with streptozotocin-induced were divided into four groups: control group, untreated...

Cutaneous wound healing is a highly complex process, which includes inflammation, cell proliferation, matrix deposition and remodelling phases. Various growth factors, like epidermal factor (EGF), play an important role during healing. However, little known about relationship between EGF oxidant–antioxidant events in cutaneous models. Thus we planned to evaluate the connection therapy oxidative stress dermal tissue followed by wounding. Fifty‐four adult male Wistar‐albino rats were randomly...

Objectives: We aimed to evaluate oxidative stress [8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA)] endothelial damage [asymmetric dimethylarginine (ADMA)] and markers of cellular inflammation [interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-α), neopterin (NP) high-sensitivity C-reactive protein (hsCRP)] in patients with diabetic nephropathy (DN) non-diabetic who were being administered hemodialysis treatment because chronic renal failure. Methods: In determining 8-OHdG, IL-6...

The purpose of this study was to evaluate the efficacy Ginkgo biloba extract (EGb 761) on oxidative events brain in cisplatin-administrated rats.Rats were divided into four experimental groups: 1) control (n=6); 2) cisplatin (8 mg/kg, intraperitoneally one dose, n=6); 3) EGb 761 (100 mg/kg for 15 days, and 4) + (n=6). After drug administration, rats sacrificed tissues removed. Nitric oxide (NO), malondialdehyde (MDA) glutathione (GSH) levels evaluated tissues.Single dose administration...

Auricularia polytricha, also known as wood ear mushroom, is a macrofungus. The aim of study was to determine the antioxidant and antimicrobial activities A. polytricha extracts with two different solutions. We used ethanol distilled water solvent in order prepare mushroom extracts. were evaluated for total status according procedures described TAS Assay Kit Rel Diagnostics®, Turkey . Antimicrobial activity investigated disc diffusion method against gram positive bacteria, negative bacteria...

The aims of the present study were to develop a colon-specific gel formulation melatonin with sodium alginate and evaluate its in vitro characteristics intracolonic performance on oxidative stress parameters, such as nitric oxide (NOx), malondialdehyde (MDA) glutathione (GSH) levels rats acetic acid-induced colitis. melatonin-alginate formulations prepared their physico-pharmaceutical properties determined. Formulation M5, which contained 3% 20% polyethylene glycol, was used for vivo...

Oxidative stress is one of the important mechanisms cisplatin-induced nephrotoxicity. Therefore, this study was designed to explore potential protective effects morin and/or hesperidin on oxidative in This performed 42 Wistar rats. Rats were divided into seven groups: control, morin, hesperidin, cisplatin, cisplatin + and hesperidin. Morin given for 10 consecutive days by oral gavage 4th day a single dose (7 mg/kg) injected intraperitoneally. After administrations, 11th experiment animals...

This study focused on the concept of possible protective effect some honey types against HCl/ethanol-induced gastric ulcers in male Wistar albino rats. Rats were pretreated with rhododendron, chestnut, and oak orally doses 1.25 2.5 g/kg, bw (body weight) for three consecutive days. On fourth day, nothing was applied, after administration anesthesia fifth their stomachs surgically removed to investigate histopathological examinations. Besides analyses blood serum profiles antioxidant...

As stated in many ethnobotany studies, Potentilla genus is traditionally used the treatment of wound healing. In this study, we aimed to investigate time-course effects methanolic extract erecta (P. erecta) (MEPE) on diabetic wounds. The subject experiments was 36 Wistar rats, divided into three main groups: non-diabetic control (NDM), (STZ-DM), and P. erecta-treated (MEPE). Diabetes induced by streptozotocin (STZ). Full-thickness excisional skin wounds were opened rats. treated with root...