A5030041481- Gastric Cancer Management and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Metastasis and carcinoma case studies
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Helicobacter pylori-related gastroenterology studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Risks and Factors
- Blood disorders and treatments
- Advanced Breast Cancer Therapies
- Gastrointestinal Tumor Research and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Parvovirus B19 Infection Studies
- Colorectal Cancer Surgical Treatments
- Childhood Cancer Survivors' Quality of Life
- Immunotherapy and Immune Responses
- Genetic factors in colorectal cancer
- PI3K/AKT/mTOR signaling in cancer
Atatürk University
2016-2025
Erzurum Regional Training and Research Hospital
2009-2014
Erzurum Technical University
2004
Istanbul University
2002
Palmetto Hematology Oncology
1998
Aim: Cancer is a major cause of death. Globocan data shows 20 million new cancer cases and 9.7 deaths year. Lung the most common globally, followed by breast, colorectal, prostate stomach cancers. types vary age, gender, race, region. Documenting regional crucial for screening, early diagnosis, treatment cancers, as well understanding underlying causes. Despite high incidence upper gastrointestinal (GI) cancers in eastern Türkiye, there little documented evidence on specific these regions....
Aim: To investigate the prognostic significance of pretreatment hemoglobin (HB)-to-red cell distribution width (RDW) ratio (HRR) in patients with muscle-invasive bladder cancer (MIBC). Materials & methods: The neutrophil-to-lymphocyte (NLR), systemic immune-inflammation index (SII), nutritional index, HRR, HB and RDW were analyzed to assess their value using Kaplan–Meier curves Cox-regression analysis 152 MIBC. Results: Univariate showed that progression-free survival (PFS) was associated...
We aimed to investigate the prognostic value of baseline neutrophil, lymphocyte, and platelet counts along with neutrophil-lymphocyte ratio (NLR) platelet-lymphocyte (PLR) in local advanced gastric cancer patients.In this retrospective cross-sectional study, a total 103 patients were included. For all, patient characteristics overall survival (OS) times evaluated. Data from complete blood count test including monocyte, white cell (WBC) (Plt) count, hemoglobin level (Hb) recorded, NLR PLR...
There is currently substantial clinical interest in zinc (Zn) as a protective agent against radiation-related normal tissue injury. To further assess this drug's potential, the effect of Zn was studied rats using radiation-induced skin injury model. Sprague-Dawley were divided into four groups. Group 1 received neither nor irradiation (control group). 2 30 Gy gamma single dose to right hind legs (RT Group). Groups 3 and 4 same plus 5 mg/kg/day (RT+5 group) or 10 orally (RT+10 group),...
ObjectiveThe aim of the study was to investigate a possible relationship between serum levels adiponectin and clinicopathological characteristics in esophageal cancer. This is first report evaluating patients with
Abstract The present study was designed to investigate the protective effects of L-carnitine (LC) on changes in levels lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) liver kidney tissues rats. Twenty-four Sprague Dawley rats were equally divided into four groups six each: control, cisplatin, L-carnitine, plus cisplatin. degree protection produced evaluated determining level malondialdehyde (MDA). activity glutathione (GSH),...
Aim: This study was performed to determine the levels of depression and anxiety, coping strategies, effects anxiety on strategies for with stress in cancer patients. Method: The designed as a definitive correlation searching investigation has been at Medical Oncology Clinic Ataturk University Research Hospital between dates July-August 2005. carried out 96 question form prepared purpose determining demographic disease-related features (type treatment, duration disease treatment) patients,...
This study aimed to determine the epidemiological characteristics of colorectal cancer in Turkey.In this multicenter, prospective, and cross-sectional registry study, data for 968 patients with from 21 centers 7 geographic regions were analyzed.Diagnosis was colon 662 (68.4%) rectum 306 (31.6%) patients. In total, 60.9% male; mean age 58.9±12.6 years. Among patients, 15.0% drinking alcohol, 17.5% smoking, 1.5% had familial history polyposis, diabetes mellitus, 1.0% inflammatory bowel...
Hormone positive breast cancer is a tumor with high mortality. Combining antihormonal therapy cyclin dependent kinase 4/6 inhibitors (CDK4/6i) has resulted in longer survival. The effect of inflammatory parameters such as c-reactive protein and protein/lymphocyte ratio (CLR) on efficacy survival CDK4/6i treatment unknown. In our study, we aimed to investigate the role CLR some predicting progression-free (PFS) CDK4/6i.
Aim: To demonstrate the prognostic importance of glucose-to-lymphocyte ratio (GLR) in metastatic gastric cancer (mGC). Methods: Retrospectively, 159 mGC patients were enrolled. Kaplan-Meier curve and Cox regression analysis used to determine value systemic immune inflammation index (SII), neutrophil-to-lymphocyte (NLR), nutritional (PNI) GLR. Results: Progression-free survival (PFS) overall (OS) associated with NLR, PNI, SII GLR by univariate analysis. Moreover, OS was Eastern Cooperative...
Aim: To show the prognostic significance of glucose-to-lymphocyte ratio (GLR) in hepatocellular carcinoma (HCC). Patients & methods: A total 150 patients with advanced HCC who were treated sorafenib our center between January 2011 and December 2019 included study retrospectively. Neutrophil-to-lymphocyte ratio, systemic immune-inflammation index, lymphocyte-to-monocyte platelet-to-lymphocyte nutritional index GLR analyzed to assess their value using Kaplan-Meier Cox regression analysis...
Abstract Background Cervical cancer is a tumor with high morbidity and mortality. The importance of inflammatory metabolic parameters affecting progression-free survival (PFS) overall (OS) has been investigated more intensively recently. We aimed to investigate the effect glucose/c-reactive protein (CRP) ratio [GCR], which shows these two together, on PFS in cervical cancer. Methods retrospectively included 90 patients adenocarcinoma squamous cell carcinoma cervix. effects clinical...
The aim of this study is to evaluate the efficacy and toxicity trastuzumab emtansine (T-DM1) in cases with metastatic breast cancer (mBC) different lines treatment.Retrospective analysis T-DM1 results human epidermal growth factor receptor 2 (Her2) positive 414 mBC from 31 centers Turkey.Except 2, all were female a median age 47. had been used as second-line therapy 37.7% number cycles was 9. Progression-free survival (PFS) overall (OS) times according line treatment. OS found 43, 41, 46, 23...
Introduction The immune checkpoint inhibitors (ICIs), which are used to activate the system and stimulate anti-tumor activity, preferred in many cancers. Atezolizumab acts by blocking programmed cell death ligand (PD-L1) may cause hyperstimulation healthy tissues like other ICIs, resulting immune-related adverse events (irAEs). Hepatitis, colitis, pneumonitis, hypophysitis, hypothyroidism, rash, musculoskeletal problems most common irAEs, on hand, acute kidney injury (AKI) thrombocytopenic...
We investigated the relationship between maximum standardized uptake value (SUVmax) of whole-body positron emission tomography/computed tomography (PET/CT) performed before treatment and demographical histopathological features in locally advanced breast cancer (LABC), as well role PET/CT evaluation pathological complete response (pCR) after neoadjuvant chemotherapy (NAC).Fifty-one LABC patients who received NAC our center 2011 2015 were retrospectively analyzed. Basal was all NAC. The...
In this study, anticancer effects of mirtazapine on rats were investigated in an adenocarcinoma model induced by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and compared with those cisplatin.For purpose, 10 mg/kg doses administered orally to one group rats, while 1 cisplatin intraperitoneally another group. At hour after administration, 200 MNNG given both groups. administration was repeated once every days through 3 months, which period, gastric tissue taken pathologically...
It is well-known that inflammation plays a significant role in cancer formation and prognosis. Both lymphocyte count red cell distribution width (RDW) has been used to predict prognosis various cancers as an indicator of inflammation. Yet, the RDW-lymphocyte ratio (RLR) determining still unknown. We aimed determine prognostic RLR cutaneous malignant melanoma (MM). One hundred fifteen patients with MM were included study retrospectively. The relationship clinical-pathological data overall...