One of the mechanisms proposed to explain lens opacification is oxidation crystallins, either by radiation or reactive oxygen species (ROS). It has been shown that melatonin both an anti-peroxidative effect on several tissues and a scavenger ROS. The purpose this study was determine antioxidant role (5 mg/kg/day) against radiation-induced cataract in after total-cranium irradiation rats with single dose 5 Gy. Sprague-Dawley were divided into four groups. Control group received neither nor...

The aim of this study was to determine the effects vitamin E (VE) and L-carnitine (LC) supplementation, separately or in combination, on radiation-induced oral mucositis myelosuppression. Group 1 received no treatment (control). 2 15 Gray 60Co gamma irradiation as a single dose total cranium (IR). 3, 4, 5 plus 40 mg/kg/day VE (IR+VE) 200 LC (IR+LC) combination (IR+VE+LC) respectively. Clinically histopathologically, assessments mucosal reactions were performed by two independent experts...

There is currently substantial clinical interest in zinc (Zn) as a protective agent against radiation-related normal tissue injury. To further assess this drug's potential, the effect of Zn was studied rats using radiation-induced skin injury model. Sprague-Dawley were divided into four groups. Group 1 received neither nor irradiation (control group). 2 30 Gy gamma single dose to right hind legs (RT Group). Groups 3 and 4 same plus 5 mg/kg/day (RT+5 group) or 10 orally (RT+10 group),...

Purpose To determine the antioxidant role of vitamin E (VE) (10 mg/kg/day) against radiation-induced cataract in lens after total-cranium irradiation rats with a single dose 5 Gy. Methods Sprague-Dawley were divided into three groups. Group 1 did not receive VE or but received both 0.1 ml physiologic saline intraperitoneally and sham (control group). 2 to total cranium Gy gamma as (RT group) plus intraperitoneally. 3 10 mg/kg/day (RT+VE The irradiated using cobalt-60 teletherapy unit....

The purpose was to determine the effects of oral zinc sulphate along with radiotherapy on anti-oxidant enzyme activities in patients head and neck cancer. Thirty cancer were randomly assigned receive either capsules (including 50 mg zinc) (n = 15) or placebo three times a day, starting day first fraction continuing throughout scheduled course including weekends 6 weeks after radiotherapy. treated telecobalt radiation at conventional fractionation 2 Gy/fraction five fractions/ week 20-35...

To evaluate the results of postoperative chemoradiotherapy in patients with gastric cancer. Gastric cancer is an important public health problem Turkey, especially eastern Anatolia region. Surgery primary modality for managing early-stage disease, but most who undergo a curative resection develop locoregional or distant recurrence. Therefore, administration adjuvant treatment has great importance. Materials and methods: Operated stage IB-IV (M0) were enrolled this study. A total 148 had...

Esophageal cancer consists of 5% all cancers. In Eastern Anatolia region Turkey, the rate was found to be 16%. The primary aim study evaluate effect localization and histologic type tumor, stage treatment modality, patient's sex, age smoking status, Karnofsky performance score, family history on survival.A total 135 patients with locally advanced esophagus were enrolled into study. factors (sex, age, localization, histology, disease, modality) survival evaluated.After end treatment, overall...

In this study we aimed to determine the role of piracetam (PIR) in preventing radiation induced cochlear damage after total-cranium irradiation (radiotherapy; RT). Male albino guinea pigs used were randomly divided into three groups. Group 1 (Control group) (n=11) received neither PIR nor irradiation, but saline solution intraperitoneally (i.p.) and sham irradiation. 2 (RT (n=32) was exposed total cranium 33 Gy 5 fractions 6.6 Gy/d for five successive days, with a calculated (alpha/beta=3.5)...

Esophageal cancer consists of 5% all cancers. In Eastern Anatolia region Turkey, the rate was found to be 16%. The primary aim study evaluate effect localization and histologic type tumor, stage treatment modality, patient's sex, age smoking status, Karnofsky performance score, family history on survival.A total 135 patients with locally advanced esophagus were enrolled into study. factors (sex, age, localization, histology, disease, modality) survival evaluated.After end treatment, overall...

ÖzAmaç: Baş ve boyun kanserlerinin tedavisinde radyoterapi önemli rol oynar.Bununla birlikte, küratif tedavide mukozit ağız kuruluğu en sık görülen yan etkilerdir.Bu prospektif, randomize çalışmanın amacı, baş kanserli hastalarda radyasyon kaynaklı tükürük bezi hasarının önlenmesinde çinko sülfat amifostinin etkinliğini kantitatif sintigrafisi (QSGS

This study investigated pre- and post-treatment tumor lymph node dimension response rates differences between side-effect profiles in patients with locally advanced inoperable nonsmall-cell lung cancer (NSCLC) receiving radiotherapy (RT) concurrent chemotherapy (CT).A total of 30 who had not previously received RT having a mean age 58.73±8.65 years sufficient hematological reserves normal hepatic renal functions were included the study. Those pleural effusion, supraventricular metastasis, N3...