A5031940532- Ginseng Biological Effects and Applications
- Chemotherapy-induced organ toxicity mitigation
- Pharmacological Effects of Natural Compounds
- Saffron Plant Research Studies
- Circadian rhythm and melatonin
- Nigella sativa pharmacological applications
- Selenium in Biological Systems
- Dietary Effects on Health
- Veterinary Pharmacology and Anesthesia
- Air Quality and Health Impacts
- Neonatal Health and Biochemistry
- Paraoxonase enzyme and polymorphisms
- Nitric Oxide and Endothelin Effects
- Acute Lymphoblastic Leukemia research
- Medicinal Plants and Bioactive Compounds
- Animal Nutrition and Physiology
- Bee Products Chemical Analysis
- Helicobacter pylori-related gastroenterology studies
- Animal health and immunology
- Veterinary Medicine and Surgery
- Herbal Medicine Research Studies
- Nanoparticles: synthesis and applications
- Sesame and Sesamin Research
- Forensic Toxicology and Drug Analysis
- Metabolism and Genetic Disorders
Kahramanmaraş Sütçü İmam University
2022
Ege University
2020
Balıkesir University
2015-2016
Atatürk University
2007-2015
Cisplatin (CDDP) is one of the most active cytotoxic agents in treatment cancer and has adverse side effects such as nephrotoxicity hepatotoxicity. The present study was designed to determine royal jelly (RJ) against oxidative stress caused by CDDP injury kidneys liver, measuring tissue biochemical antioxidant parameters investigating apoptosis immunohistochemically. Twenty-four Sprague Dawley rats were divided into four groups, group C: control received 0.9% saline; CDDP: injected i.p. with...
Abstract The present study aimed to investigate the protective effect of Spirulina platensis (SP) on gentamicin sulphate (GS)‐induced changes in levels lipid peroxidation and endogenous antioxidants kidney rats. Sprague‐Dawley rats were treated separate groups as follows for 7 consecutive days: control (C), (100 mg/kg i.p.) (GS), (1000 orally) plus (SP + GS). degree protection was evaluated by determining effects malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD),...
Cisplatin (CDDP), one of the most active cytotoxic agents against cancer, has adverse side effects, such as nephrotoxicity and hepatotoxicity. The present study was designed to investigate potential protective effect pomegranate seed extract (PSE) oxidative stress caused by CDDP injury kidneys liver measuring tissue biochemical antioxidant variables immunohistochemically testing caspase-3–positive cells. Twenty-four Sprague–Dawley rats were divided into 4 groups: control; CDDP: injected...
Abstract The present study was designed to investigate the protective effects of L-carnitine (LC) on changes in levels lipid peroxidation and endogenous antioxidants induced by cisplatin (cis-diamminedichloroplatinum II, CDDP) liver kidney tissues rats. Twenty-four Sprague Dawley rats were equally divided into four groups six each: control, cisplatin, L-carnitine, plus cisplatin. degree protection produced evaluated determining level malondialdehyde (MDA). activity glutathione (GSH),...
Diabetes mellitus (DM) is a metabolic disease, which causes an increase in the proinflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin 1β (IL-1β), also proliferation of monocyte chemotactic protein. In present study, potential effects melatonin on cytokines, hematological values, lymphoid tissues were investigated diabetic rats. 36 male rats randomly divided into 4 groups as follows: Control, Mel (melatonin), DM, DM-Mel. For 15 days, isotonic saline solution was given to...
We investigated the possible protective effects of ellagic acid on rat kidneys exposed to nicotine during fetal period. Twenty pregnant female rats were divided randomly into four groups: control (C), (N), (EA) and + (N EA). Nicotine treatments continued throughout pregnancies for 15 days after delivery. On day 15, all neonatal pups sacrificed their removed biochemical histopathological examination. The treatment significantly decreased body weight, total glutathione (GSH), peroxidase...
This study was performed to determine caspase-3 and CD68 activities in lymphoid tissues of rats exposed Cisplatin (CDDP) induced toxicity L-carnitine (L-Car) protection. Group control received single-dose intraperitoneal (i.p.) 1 ml isotonic saline, L-Car injections 500 mg/kg bw. i.p., CDDP a injection 7 bw i.p. all at once, + single doses for 10 consecutive days following When compared the group, numbers total WBC were decreased while relative increase lymphocyte percentages observed...
To evaluate the protective effects of royal jelly (RJ) on changes caused by cisplatin in paraoxonase-1 (PON-1) and arylesterase (ARE) activities. Materials methods: Twenty-four Sprague-Dawley rats were divided into 4 groups 6: control, (300 mg kg^{-1} day^{-1}, (7 body weight), day^{-1} plus a single dose weight). After experimental procedures, blood liver tissue samples taken from each animal. The RJ evaluated PON-1, ARE (in homogenates), serum alanine aminotransferase measurements. was...
This study was designed to investigate the protective effects of Panax ginseng against acute brain damage induced by CCl4 in rats. A total 30 healthy female Sprague–Dawley rats were divided three groups. Sedentary control group (group C) injected intraperitoneally (i.p.) with physiological saline as placebo for 7 consecutive days. toxication i.p. a single dose CCl4). plus (200 mg/kg) feeding through an orogastric tube days prior injection + PG). The degree protection tissue evaluated levels...
This study was performed to investigate the effects of alfuzosin, doxazosin and tamsulosin in vitro on trigone smooth muscle rabbit. In this study, fifteen rabbits weighing 2.5 - 3 kg were used. One strip shape a prepared for each isolated bladders. Firstly, an initial tension 1 g placed segment, we waited equilibration by constantly bubbling with 95% O 2 5% CO . Next, determination level electrical stimulation which created submaximal contraction effective dosage found they determined...
Amaç: Bu çalışmada, yüzme egzersizi yaptırılan farelere alfa-lipoik asit (ALA) uygulamasının lipit peroksidasyonu, kreatin kinaz ve laktat düzeyleri üzerine etkisi incelendi. Gereç Yöntemler: Çalışmada 20-25 gram (gr) ağırlığında, 30 adet Swiss albino cinsi fare kullanıldı. Fareler kontrol, ALA-50 ALA-100 şeklinde her grupta 10 olacak şekilde 3 gruba ayrıldı. Kontrol grubuna gün boyunca intraperitoneal (i.p.) izotonik serum uygulandı. ALA gruplarına ise i.p. yolla sırasıyla 50 100 mg/kg...
The aim of this study was to determine the enzyme-histochemical, histometric and hematological features peripheral blood cells in Sparrowhawk (Accipiter nisus). Therefore, samples obtained from wings (brachial vein) nine were used. Red cell (RBC) white (WBC) counts, enumeration leukocyte types, hematocrit (Htc) value hemoglobin concentration determined by hemocytometric methods on samples. Also, erythrocyte indices (mean corpuscular volume (MCV), mean (MCH) (MCHC)) calculated. Histometric...