A5002599142- Gastric Cancer Management and Outcomes
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Cancer Treatment and Pharmacology
- Colorectal Cancer Surgical Treatments
- Lymphoma Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Biosimilars and Bioanalytical Methods
- Head and Neck Cancer Studies
- Inflammatory Biomarkers in Disease Prognosis
- Multiple and Secondary Primary Cancers
- Esophageal Cancer Research and Treatment
- Peptidase Inhibition and Analysis
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Estrogen and related hormone effects
- Gastrointestinal Tumor Research and Treatment
- Colorectal and Anal Carcinomas
- Brain Metastases and Treatment
- Lung Cancer Research Studies
- Breast Lesions and Carcinomas
Memorial Ankara Hospital
2024-2025
Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi
2016-2023
Sağlık Bilimleri Üniversitesi
2017-2023
University of Health Science
2020-2023
Ankara Yıldırım Beyazıt University
2014-2021
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2020
Dokuz Eylül University
2020
Education and Research Institute
2019
Ankara Numune Eğitim ve Araştırma Hastanesi
2014-2016
Konya Eğitim ve Araştırma Hastanesi
2013-2016
Abstract Objectives Head and neck cancers (HNCs) represent a significant global health concern due to high morbidity mortality rates. Despite therapeutic advances, the prognosis for advanced or recurrent cases remains challenging. Nivolumab obtained approval metastatic HNC based on Phase III CheckMate 141 trial. This study aimed evaluate real-world outcomes of nivolumab in patients with non-nasopharyngeal HNC. Design In this multicenter retrospective study, we analyzed 124 who received...
Hormone positive breast cancer is a tumor with high mortality. Combining antihormonal therapy cyclin dependent kinase 4/6 inhibitors (CDK4/6i) has resulted in longer survival. The effect of inflammatory parameters such as c-reactive protein and protein/lymphocyte ratio (CLR) on efficacy survival CDK4/6i treatment unknown. In our study, we aimed to investigate the role CLR some predicting progression-free (PFS) CDK4/6i.
The aim of the study was to investigate association between molecular subtypes and patterns relapse in breast cancer patients who had undergone curative surgery.We retrospectively evaluated 1,350 with relapses after surgery 1998 2012 from referral centers Turkey. Patients were divided into 4 biological according immunohistochemistry grade: triple negative, HER2 overexpressing, luminal A B.The percentages A, B, HER2-overexpressing, triple-negative 32.9% (n = 444), 34.9% 471), 12.0% 162),...
Sorafenib is a multi‑targeted tyrosine kinase receptor inhibitor used to treat patients with advanced gastrointestinal stromal tumors (GISTs). The present study evaluated the efficacy and tolerability of sorafenib therapy for GISTs. Between January 2001 November 2012, 25 patients, from multiple centers, who had received as third‑ or fourth‑line treatment GISTs were investigated retrospectively. In total, 17 male eight female. median age was 54.0 years (range, 16‑82 years). From 21 imatinib...
Most data on prognostic factors for patients with high-grade undifferentiated pleomorphic sarcoma (HGUPS) is obtained from analyses of soft tissue sarcomas. The purpose this study was to evaluate the clinicopathologic features and their impact outcomes specifically in diagnosed HGUPS. In multicenter trial, we retrospectively analyzed 112 who were treated at 12 different institutions Turkey. We collected concerning patients, tumor characteristics, treatment modalities. There 69 males (61.6 %)...
This study investigates the prognostic significance of Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) score and Prognostic Nutritional Index (PNI) in metastatic head neck cancers. Retrospective analysis was conducted on data obtained from January 2014 to June 2022 for 68 patients using rigorous statistical methods. HALP PNI scores, derived routine laboratory parameters, were categorized into low high groups respective median values. determined through Kaplan–Meier survival analyses Cox...
The relapses of colorectal cancer (CRC) frequently occur in 2 years period after the time diagnosis. However, a considerable proportion patients relapse late period.The aim present study is to define factors predicting early and with stage CRC.A total 250 CRC, who relapsed completion primary therapy between 2005 2014, were enrolled study. According relapse, divided into two groups as follows: Early (Group 1: Within first 24 months) 2: Later than months). Clinicopathological features survival...
In Muslim majority countries (MMC) opioid use for pain management is extremely low. The underlying factors contributing to this are not well defined.The aim of study was survey the attitudes cancer patients towards morphine in a MMC and identify that influence patient decisions accept or refuse as treatment pain.Patients were questioned whether they had not, severity medications management. Questions included what type medication thought was, would be willing take if recommended basis their...
Background: XELOX plus bevacizumab (XELOX-Bev) and FOLFIRI Bevacizumab (FOLFIRI - Bev) treatments are an effective strategies patients with metastatic colorectal cancer (mCRC).The aim of this study was to compare efficacy first-line XELOX-Bev treatment vs FOLFIRI-Bev for mCRC. Materials Methods: A total 409 mCRC who received chemotherapy were included divided into 2 groups. Group 1 (n=298) (n=111) FOLFIRI-Bev. Comparisons made in terms overall (OS) progression-free (PFS) survival, response...
Patients with advanced non-small cell lung cancer (NSCLC) generally require second-line treatment although their prognosis is poor. In this multicenter study, we aimed to detect the characteristics related patients and disease that can predict response treatments in NSCLC. Data of 904 who have progressed after receiving first-line platinum-based chemotherapy 11 centers diagnosis stage IIIB IV NSCLC were evaluated for retrospectively analyzed. The role different factors determining benefit...
We present a patient with uncommon metastases of lung cancer. The has been followed-up for early stage laryngeal carcinoma in the remission and had dyspeptic complaints as well. A 62-year-old male epigastric three months. In upper endoscopy, biopsy specimen taken from polyp second region duodenum was reported squamous cell Immunohistochemical staining tumor cells were positive CK5/6, p40, p63. mass right detected on thorax tomography. result transthoracic needle indicated Duodenal metastasis...
Background: ABVD (doxorubicin, bleomycin, vinblastine (Vb) and dacarbazine) is the standard regimen in Hodgkin's lymphoma (HL).Vincristine (O) a mitotic spindle agent like Vb. We aimed to evaluate efficacy safety of O as part ABOD HL. Materials Methods: Patients who had were enrolled. Stage I-II HL evaluated for unfavorable risk factors according NCCN. National Cancer Institute Common Toxicity Criteria was used toxicity. Results: Seventy-nine patients our center between 2003 2007...
The standard therapy for stage I rectum cancer is surgical resection. Currently, there no strong evidence to suggest that any type of adjuvant beneficial. risks local relapse and distant metastasis are higher in rectal tumors. Therefore, while clearly defined absolute indication lymph node negative colon cancers, tumors T3N0 require treatment. Due the more aggressive nature we explored clinical pathologic factors could predict risk Stage (T1-T2) disease whether was progression-free survival...
Background: Adding taxanes to adjuvant antracycline and cyclophosphamide (AC) in combination may provide significant improvement node-positive high risk node-negative breast cancer (BC) patients. However, the optimal dose role of dose-dense (DD) chemotherapy have yet be determined. The aim this study was compare efficacy a DD paclitaxel (P)-AC with conventional weekly P-AC or docetaxel D-AC combinations patients cancer. Materials Methods: Newly diagnosed 280 BC from 1998 2013 three clinics...
Coexistence of two or more primary cancers is a relatively rare case.Not with standing that the coexistence multiple often discussed in literature, there small number publications concerning squamous cell lung carcinoma and renal cancer.In this case report, detection both cancer one male patient going to be discussed.
<b><i>Background:</i></b> The objective of this study was to identify prognostic factors affecting the recurrence-free survival (RFS) in patients who received a 52-week trastuzumab therapy for HER2-positive early stage breast cancer (EBC). Patients and <b><i>Methods:</i></b> medical records all with EBC from 10 centers were analyzed. Pathologic clinical tumor characteristics evaluated 424 female 52 weeks adjuvant EBC. Survival estimated using...
e18004 Background: Head and neck cancers (HNCs) represent a significant global health concern due to high morbidity mortality rates. The prognosis for advanced or recurrent cases remains challenging. Nivolumab obtained approval metastatic HNC based on the Phase III CheckMate 141 trial. This study aimed evaluate real-world outcomes of nivolumab in patients with non-nasopharyngeal HNC. Methods: In this multicenter retrospective study, we analyzed 124 who received second-line setting beyond....