A5032340811- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Treatments and Studies
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Metastasis and carcinoma case studies
- Chemotherapy-induced cardiotoxicity and mitigation
- Radiomics and Machine Learning in Medical Imaging
- Biosimilars and Bioanalytical Methods
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Neutropenia and Cancer Infections
- Lung Cancer Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Advanced Breast Cancer Therapies
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Medical and Health Sciences Research
- Endometrial and Cervical Cancer Treatments
- Renal and related cancers
Erciyes University
2012-2025
Istanbul University
2024
Bozok Universitesi
2021
Kayseri Eğitim ve Araştırma Hastanesi
2014-2020
Erciyes Üniversitesi Tıp Fakültesi Hastaneleri
2020
Sağlık Bilimleri Üniversitesi
2017
Prior studies showed a relationship between serum albumin and the to globulin ratio with different types of cancer. We aimed evaluate predictive value albumin-globulin (AGR) for survival patients lung adenocarcinoma.This retrospective study included 240 adenocarcinoma patients. Biochemical parameters before chemotherapy were collected status was obtained from hospital registry. The AGR calculated using equation AGR=albumin/ (total protein-albumin) ranked lowest highest, total number being...
Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective treatments for EGFR mutant (EGFRm) metastatic non-small cell lung cancer (mNSCLC). However, the benefit of EGFR-TKIs varies. We aimed to determine impact clinicopathological features on duration response in EGFRm mNSCLC. Method: Patients diagnosed with mNSCLC who underwent EGFR-TKI therapy were retrospectively reviewed. Cox regression analyses employed association between PFS rates and...
Background: Medication errors in oncology may cause severe clinical problems due to low therapeutic indices and high toxicity of chemotherapeutic agents.We aimed investigate unintentional medication underlying factors during chemotherapy preparation administration based on a systematic survey conducted reflect nurses experience.Materials Methods: This study was 18 adult units with volunteer participation 206 nurses.A developed by primary investigators (MAEs) defined preventable prescription...
Introduction: Uterine sarcomas are a group of heterogenous and rare malignancies the female genital tract there is lack consensus on prognostic factors optimal treatment. Objective Methodology: To perform retrospective evaluation clinicopathological characteristics, treatment outcomes 93 patients with uterine who were diagnosed treated at 4 different centers from November 2000 to October 2010. Results: Of patients, 58.0% had leiomyosarcomas, 26.9% malignant mixed Mullerian tumors, 9.7%...
Purpose: To determine expression levels of CD44 and ALDH1/2, known cancer stem cell (CSC) markers, in stomach adenocarcinomas assess relationships with clinicopathologic parameters prognosis. Methods: Eighty patients diagnosed gastric between the years 2011-2015 were included this study characteristics, postoperative prognostic indexes marker ALDH1/2 paraffin-embedded tumour sections analyzed immunohistochemically. Clinicopathologic evaluated using chi-square test t-test. Survival analyses...
The main goal of this study was to examine whether the occurrence hypothyroidism during sunitinib therapy in patients with metastatic renal cell carcinoma (mRCC) is associated a better outcome.The enrolled 81 pathologically proven mRCC who were treated between March 2008 and June 2013.Thyroid function evaluation comprised (free-thyroxine) FT4 thyroid-stimulating hormone (TSH) before treatment at day 1 each 6-week cycle. Survival analysis performed using Kaplan-Meier method, differences among...
There is no suggested molecular indicator for the determination of which patients will benefit from anti-angiogenetic treatment in metastatic colorectal cancers.In this study, VEGF and HIF-1α expression their clinical significance were studied tumor tissues with cancer receiving bevacizumab-based treatment. assessed by immunohistochemistry primary tumors 53 chemotherapy combination first line bevacizumab.The rate low-VEGF group was 38%, while it 62% high group. While median progression-free...
Background: Non-epithelial malignant ovarian tumors and clear cell carcinomas, Brenner tumors, transitional carcinoid of the ovary are rare (ROTs). In this study, our aim was to determine clinicopathological features ROT patients prognostic factors associated with survival. Materials Methods: A total 167 who underwent initial surgery were retrospectively analyzed. Prognostic that may influence survival evaluated by univariate multivariate analyses. Results: Of patients, 75 (44.9%) diagnosed...
The standard treatment in the metastatic colorectal cancer consists of 5-FU based infusional regimens. However, with oral fluoropyrimidines, equal tumor responses may be obtained. Capecitabine causes macrocytosis cells by inhibition DNA synthesis. In this context, a relationship was found between mean corpuscular volume (MCV) and response to therapy breast patients treated Capecitabine, but whether also pertains has not been established.A total 102 oxaliplatin (XELOX) ±Bevacizumab...
We aimed to evaluate prognostic factors and response rates various treatment approaches patients with synovial sarcoma in an advanced setting.We retrospectively reviewed the medical records of 55 (18 pts; 32.7% women) diagnosed sarcomas. Twenty had metastatic disease at time diagnosis while remainder study group consisted who developed or inoperable locally during follow up.The median up was 15 months (range: 1-53). Regarding outcomes for patients, 3 5 year overall survival were 26% 14%,...
Background: Capecitabine is an oral fluoropyrimidine derivative which frequently used alone or in combination regimens for the treatment of metastatic breast cancer. Although overall and progression free survivals have increased recent years with use new generation drugs, predictive factors that would further improve outcomes are needed. Previous studies demonstrated relation between post-treatment increase mean corpuscular volume (MCV) predicting therapy response as well survival. The...
Background: To determine the frequency of HER-2 overexpression in colorectal cancer (CRC) patients, and to explore relationship between clinicopathological prognostic factors their effects on survival, based immunohistochemistry (IHC) fluorescent situ hybridization (FISH) analysis. Materials Methods: The study included 80 patients with a histologically proven diagnosis CRC that received adjuvant FOLFOX-4 chemotherapy at our department March 2006 September 2010. Patient data were analyzed...
The aim of this study is to evaluate the tolerability and toxicity adjuvant chemoradiotherapy (CRT) analyze prognosis in patients with operable gastric cancer.The retrospective analysis included 723 cancer; stage IB-IV (M0), received CRT from 8 Medical Centers Turkey between 2003 2010.The patients' age, sex, tumor localization, Lauren classification, grade disease, type dissection, status survival rate were analyzed.All divided into two groups as tolerable group intolerable .Among patient,...
DCF chemotherapy regimen includes docetaxel, cisplatin, and 5-fluorouracil (5-FU). Cardiotoxicity is one of the well-known side effects 5-FU, cisplatin. In addition, complications are more apparent when these three agents given in combination. For first time we describe a case acute pericarditis associated with male patient. A 55-year-old man recently diagnosed syncrone nasopharenx non-small cell lung carcinoma was admitted to oncology unit for chemotherapy. On fourth day infusion therapy he...
The aim of this retrospective study was to determine response rates, progression-free survival (PFS), overall (OS) and toxicity gemcitabine paclitaxel combinations with advanced or metastatic non-small cell lung cancer patients (NSCLC) who have progressive disease after platinum-based first-line chemotherapy.We retrospectively evaluated the file records treated plus in NSCLC cases a second-line setting. chemotherapy schedule as follows: 1500 mg/m2 150 administered every two weeks.Forty-eight...