A5026108996- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Brain Metastases and Treatment
- Breast Cancer Treatment Studies
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Thyroid Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Renal cell carcinoma treatment
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Head and Neck Cancer Studies
- Lymphoma Diagnosis and Treatment
- Neutropenia and Cancer Infections
- Genetic factors in colorectal cancer
- Occupational and environmental lung diseases
- CNS Lymphoma Diagnosis and Treatment
- Breast Lesions and Carcinomas
Inonu University
2012-2024
Fırat University
2005-2013
Dokuz Eylül University
2013
Gaziantep University
2013
Marmara University
2013
Dicle University
2013
Hacettepe University
2004-2007
Lung cancer (LC) is the leading cause of cancer-related deaths. Oxidative DNA damage may contribute to risk. The antioxidant paraoxonase (PON1) an endogenous free radical scavenger in human body. aim this study was determine serum PON1 and arylesterase (ARE) activities patients with newly diagnosed LC. This case control involved a total 39 LC (untreated) same number age- sex-matched healthy individuals. Serum ARE addition lipid parameters were measured both groups. found be lower compared...
To evaluate the clinicopathologic characteristics and treatment outcomes of young patients with colorectal cancer (CRC).Between May 2003 June 2010, 76 were found eligible for this retrospective study. Age, sex, presenting symptoms, acute presentation, family history, presence polyps, histologic features, localization stage tumor, outcomes, time site recurrence, sites metastasis, survival recorded from patient files.Seventy-six (55.3% male) a median age 23 years evaluated. Patients evaluated...
<b><i>Background:</i></b> The aim of this study is to determine the relationship between survival outcomes and biological subtype in breast cancer patients with brain metastases. <b><i>Methods:</i></b> We retrospectively evaluated clinical data from 422 metastases 2001 2011 referral centers Turkey. population was divided into four subtypes according their hormone receptor status HER2 expression. <b><i>Results:</i></b>...
Antivascular endothelial growth factor tyrosine kinase inhibitors have been used recently in the treatment of advanced differentiated thyroid cancer (DTC) and medullary (MTC). Off-label sorafenib is Turkey with special permission by Ministry Health for this indication.Patients DTC MTC were retrospectively identified from Turkish database. Data on these patients prospectively collected before granted to use sorafenib.Thirty complete data analyzed: 14 (papillary number [n] =10; follicular n=4)...
Background: Non-epithelial malignant ovarian tumors and clear cell carcinomas, Brenner tumors, transitional carcinoid of the ovary are rare (ROTs). In this study, our aim was to determine clinicopathological features ROT patients prognostic factors associated with survival. Materials Methods: A total 167 who underwent initial surgery were retrospectively analyzed. Prognostic that may influence survival evaluated by univariate multivariate analyses. Results: Of patients, 75 (44.9%) diagnosed...
The majority of patients with pancreatic cancer is advanced disease.Several randomized Phase II and III trials suggest that the combination gemcitabine cisplatin (GemCis) response rates were higher than Gemcitabine (Gem) alone, however not enough powered to indicate a statistically significant prolongation survival in adenocarcinoma.The aim this retrospective multicenter study evaluated efficiency Gem alone versus GemCis locally and/or metastatic adenocarcinoma .A total 406 patients, from...
To investigate the role of surgical resection primary tumor on overall survival (OS) in advanced gastric cancer patients at time diagnosis.The rates metastatic whose was resected diagnosis were compared with nonresected.The median progression-free and OS operated nonoperated group 10 versus 6, 14 9 months, respectively (p < 0.001). In multivariate analysis, tumor, Eastern Cooperative Oncology Group performance status, second-line chemotherapy had a significant effect (hazard ratio [HR]: 0.52...
It has been thought that hepatocyte growth factor (HGF) levels increase during acute phases of infectious diseases. The aim this study was to determine whether HGF, C-reactive protein (CRP), and proinflammatory cytokines have any diagnostic prognostic value, assess HGF as a biomarker in patients with febrile neutropenia. Materials methods: This included 20 neutropenia the group healthy individuals control group. Serial measurements serum CRP, cytokine were performed by enzyme-linked...
We compared the efficacy and safety of low-molecular-weight heparins (LMWHs) in patients with cancer who are at low risk venous thromboembolism (VTE). Patients were treated by medical oncologists Turkey 15 sites, where they enrolled followed up for a period 12 months. Due to study design, there was no specific treatment protocol LMWH. Primary end points time change VTE status. Of included 250 patients, 239 (95.6%), 176 (70.4%), 130 (52.0%), 91 (36.4%) completed their day 15, month 3, 6,...
Synovial sarcoma usually arises in the extremities and close proximity to large joints. Primary synovial of anterior abdominal wall is rare. A 17-year-old girl was admitted hospital with a palpable mass, there 9.5 cm x 7.5 6-cm lobulated, cystic, semisolid lesion external oblique muscle shown on magnetic resonance image. She then operated pathology consistent sarcoma. The presence extraarticular sites such as argues against an origin from arthrogenous mesenchyme.
Almost half of all patients diagnosed with non-small cell lung cancer (NSCLC) have distant metastases at presentation. One-third NSCLC will brain metastases. Without effective treatment, the median survival is only 1 month. However, it difficult to treat systemic chemotherapy since agents difficulty crossing blood-brain barrier. Therefore, important estimate patient's prognosis. The aim this study was analyze prognostic factors for in Turkish who received after cranial irradiation...
The aim of this retrospective study was to determine response rates, progression-free survival (PFS), overall (OS) and toxicity gemcitabine paclitaxel combinations with advanced or metastatic non-small cell lung cancer patients (NSCLC) who have progressive disease after platinum-based first-line chemotherapy.We retrospectively evaluated the file records treated plus in NSCLC cases a second-line setting. chemotherapy schedule as follows: 1500 mg/m2 150 administered every two weeks.Forty-eight...
Neutropenia is a serious adverse event that necessitates dosage reduction in patients receiving chemotherapy. In this study, we evaluated the oxidative stress and antioxidant parameters neutropenic after chemotherapy both during period successful treatment of neutropenia with filgrastim.We studied paraoxonase (PON1), arylesterase (ARE), malondialdehyde (MDA), high-density lipoprotein (HDL), lactate dehydrogenase (LDH), alkaline phosphatase (ALP) addition to routine biochemical hematologic...
Sunitinib malate is a multitargeted oral tyrosine kinase inhibitor (TKI) which used in treatment of metastatic renal cell carcinoma with side effects such as diarrhea, mucositis, asthenia and myelosuppression. Serious toxicity associated sunitinib rare situation. However; there are few cases reported the literature. As result inhibition that caused by agent at receptor level, vascular endothelial growth factor (VEGF) level increases. These increased VEGF levels considered to having positive...
Background Differentiated thyroid cancer (DTC) is the most prevalent endocrine malignancy with a recurrence rate of about 20%, necessitating better predictive methods for patient management. This study aims to create relational classification model predict DTC by integrating clinical, pathological, and follow-up data. Methods The balanced dataset comprises 550 samples collected over 15 years, featuring 13 clinicopathological variables. To address class imbalance in status, Synthetic Minority...