A5064384585- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Treatments and Studies
- Multiple and Secondary Primary Cancers
- Cancer Immunotherapy and Biomarkers
- Inflammatory Biomarkers in Disease Prognosis
- Gastric Cancer Management and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Chemotherapy-induced organ toxicity mitigation
- Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Hematopoietic Stem Cell Transplantation
- Metastasis and carcinoma case studies
- Lung Cancer Research Studies
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Lung Cancer Treatments and Mutations
- Esophageal Cancer Research and Treatment
- Cancer, Lipids, and Metabolism
- Polyomavirus and related diseases
- Intraperitoneal and Appendiceal Malignancies
- Immune Cell Function and Interaction
Bilkent University
2025
Ankara Bilkent City Hospital
2024-2025
Memorial Ankara Hospital
2021-2025
Ankara University
2024
Sağlık Bilimleri Üniversitesi
2021-2024
Ankara Yıldırım Beyazıt University
2023-2024
Software (Germany)
2024
City Hospital
2024
Ministry of Health
2023
Creative Commons
2023
Systemic inflammatory response was shown to play an important role in development and progression of many cancer types different inflammation-based indices were used for determining prognosis. We aimed investigate the prognostic effects neutrophil lymphocyte ratio (NLR) nutritional index (PNI) patients with non-small cell lung (NSCLC).NSCLC diagnosed our institution retrospectively reviewed. Demographic clinicopathologic characteristics recorded. NLR PNI calculated before application any...
Background and Objectives: Despite advances in surgery perioperative chemotherapy, locally advanced gastric cancer continues to pose significant challenges, creating a pressing need for biomarkers capable of predicting therapeutic efficacy survival outcomes. This study evaluates the prognostic predictive significance large unstained cells (LUCs), morphologically distinct subset white blood identified peripheral that remain by standard hematological dyes, as potential indicators immune...
Despite the extensive research on hepatocellular carcinoma (HCC) exploring various treatment strategies, survival outcomes have remained unsatisfactory. The aim of this was to evaluate ability machine learning (ML) methods in predicting probability HCC patients. study retrospectively analyzed cases patients with stage 1-4 HCC. Demographic, clinical, pathological, and laboratory data served as input variables. researchers employed feature selection techniques identify key predictors patient...
Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but are associated with immune-related adverse events (irAEs). Pembrolizumab, an anti-PD-1 antibody, is widely used in non-small cell lung (NSCLC), yet immune thrombocytopenia remains a rare potentially fatal complication. We report case of 55-year-old male metastatic NSCLC who developed pembrolizumab-associated thrombocytopenia. The patient initially responded well to combination therapy pembrolizumab, carboplatin, and...
Introduction: Biliary tract cancers (BTC) comprise a heterogeneous group of malignancies, including gallbladder cancer, intrahepatic cholangiocarcinoma, and extrahepatic cholangiocarcinoma. The main determinants prognosis in BTC are the stage disease eligibility for curative treatment. Additionally, liver functional capacity is also one factors influencing survival biliary cancers. age–bilirubin–INR–creatinine (ABIC) score has been previously shown to predict hepatic diseases. aim our study...
Data are available indicating that red blood cell distribution width (RDW) is higher in cancer patients compared to healthy individuals or benign events. In our study, we aimed investigate the influence of different RDW levels on survival lung patients.Clinical and laboratory data from 146 with 40 subjects were retrospectively studied. was recorded before application any treatment. Patients categorised according four cut-off values (median RDW, determined by ROC curve analysis, upper limit...
This study aims to report the efficacy and safety of capecitabine plus temozolomide (CAPTEM) across different lines treatment in patients with metastatic neuroendocrine tumors (NETs).
Prognosis of metastatic gastric cancer is poor and median survival between 3 5 months. Response rates combination chemotherapy with 5-fluorouracil (5-FU) cisplatin in first-line treatment have been found to be 20-25% the English literature. It has demonstrated that adding docetaxel improved time progression overall survival. However, toxicity docetaxel-cisplatin-5-FU protocol were high. In our study we compared efficacy cisplatin-5-FU-folinic acid (CFF) modified (mDCF) regimens...
Background: Ewing sarcoma is a small round cell tumor arising from soft tissue and bone that predominantly affects children adolescents. The most unfavorable prognostic factor the presence of distant metastasis at time diagnosis. Materials Methods: records 26 patients (14 male, 12 female) were re-evaluated retrospectively. Results: median age was 26.5 (19-42) years. Eight (31%) showed primary in their extremities, 8 thorax, 4 (15%) vertebra, head neck, 2 (8%) abdomen. Five (19%) had...
The aim of this study was to assess the use 5-fluorouracil (5-FU), leucovorin and oxaliplatin (FOLFOX) regimens in clinical practice according their efficacy toxicity.Patients who received oxaliplatin-containing after curative resection for colorectal carcinoma from 10 different oncology centers between May 2004 December 2009 were included study. All patients treated with FOLFOX regimens. Patients rectal also chemoradiotherapy 5-FU 2 cycles a regimen.The median age 56 years (range 17-78). Of...
Objective: There are some data regarding the role of cystatin C, a cysteine proteinase inhibitor, in determining glomerular filtration rate (GFR) more accurately. We aimed to evaluate correlation serum C levels with creatinine and GFR calculated by Cockcroft–Gault modification diet renal disease (MDRD) formulations patients who received cisplatin-based chemotherapy. also intended demonstrate its potential use early prediction function changes these patients. Materials methods: In study, 34...
Introduction: Locoregional gastric cancer is a still serious problem and perioperative treatments may improve the success of management. Different regimens were examined. The present study purposed to compare efficacy fluorouracil-leucovorin-oxaliplatin-docetaxel (FLOT) docetaxel-cisplatin-fluorouracil (DCF) regimens. Methods: A retrospective multicenter assessed patients with locoregional cancer. There are 240 (137 DCF, 103 FLOT). Survival rates compared. Results: Demographic features...
Introduction Pembrolizumab is a humanized monoclonal antibody IgG4 programmed cell death protein 1 antagonist, and its use in oncology has been increasing recent years, providing durable favorable responses tolerable toxicity profiles various types of cancer. We describe case pembrolizumab related perforated appendicitis patient with stage 3C malignant melanoma (MM). Case report A 70-year-old male who had no known disease was diagnosed MM as result the excision mass on his right shoulder....
: In this study, we evaluated the impact of seven immune indexes on treatment response and survival outcomes in advanced non-small-cell lung cancer (NSCLC) patients receiving second-line subsequent nivolumab under real-life conditions.
In recent years, machine learning (ML) methods have gained significant popularity among medical researchers interested in cancer. We aimed to test different models predict both overall survival and at specific time points patients with non-metastatic colorectal cancer (CRC). The clinicopathological treatment data of CRC more than 10 years follow-up a single center were retrospectively reviewed. 1, 2, 3, 5, 10-year rates for all stages I-III statistically calculated using the Kaplan-Meier...
The majority of patients with pancreatic cancer is advanced disease.Several randomized Phase II and III trials suggest that the combination gemcitabine cisplatin (GemCis) response rates were higher than Gemcitabine (Gem) alone, however not enough powered to indicate a statistically significant prolongation survival in adenocarcinoma.The aim this retrospective multicenter study evaluated efficiency Gem alone versus GemCis locally and/or metastatic adenocarcinoma .A total 406 patients, from...
Background: For early detection of renal damage during the usage cisplatin based chemotherapy, changes in function should be monitored carefully. In recent years, neutrophil gelatinase-associated lipocalin, a small polypeptide molecule, has shown promise as marker acute failure. The aim this present study was to assess possible risk prediction cisplatin-induced nephrotoxicity using serum NGAL. Materials and Methods: A total 34 consecutive patients with documented creatinine at least 24 hours...