A5076920638- Neuroendocrine Tumor Research Advances
- Lung Cancer Treatments and Mutations
- Inflammatory Biomarkers in Disease Prognosis
- Hematological disorders and diagnostics
- Neutropenia and Cancer Infections
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Pharmaceutical studies and practices
- Colorectal Cancer Treatments and Studies
- Blood disorders and treatments
- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Lung Cancer Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Renal cell carcinoma treatment
- Cancer Treatment and Pharmacology
- Prostate Cancer Diagnosis and Treatment
- Biomarkers in Disease Mechanisms
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Chromatin Remodeling and Cancer
- Nuclear Receptors and Signaling
- Parkinson's Disease and Spinal Disorders
Gazi University
2019-2024
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2023-2024
Sağlık Bilimleri Üniversitesi
2023-2024
Gazi Hastanesi
2021-2023
University of Health Science
2023
Hacettepe University
2017
Growth differentiation factor-15 (GDF-15), a member of the TGF-β superfamily, is overexpressed in various cancers and facilitates immune evasion by inhibiting T-cell activation. GDFATHER-TRIAL's phase 2a results demonstrated promising outcomes when combining GDF-15 neutralizing antibody visugromab (CTL002) with nivolumab, enhancing response to immunotherapy. This study evaluated prognostic significance expression non-small cell lung cancer (NSCLC) tumor tissues terms immunotherapy response....
Introduction: The current study aims to evaluate the OX40, TIM-3, LAG-3, and PD-L1 targeted pathways in regulation of T-cell activity sarcoma patients determine their relationship with overall survival (OS). Method: This included one hundred eleven bone soft tissue diagnosed two centers between 2010 2020. TIM-3 expression levels were evaluated immunohistochemically from pathology preparations. Results: staining was detected tumor cells, inflammatory cells tissue. In univariate analysis, no...
Introduction: Locoregional gastric cancer is a still serious problem and perioperative treatments may improve the success of management. Different regimens were examined. The present study purposed to compare efficacy fluorouracil-leucovorin-oxaliplatin-docetaxel (FLOT) docetaxel-cisplatin-fluorouracil (DCF) regimens. Methods: A retrospective multicenter assessed patients with locoregional cancer. There are 240 (137 DCF, 103 FLOT). Survival rates compared. Results: Demographic features...
The current study aimed to evaluate the effect of time duration reach lowest prostate-specific antigen (PSA) from onset first-line hormonal treatment (time nadir PSA, TTNpsa) on survival in castration-naive metastatic prostate cancer (CN-MPC) patients.
Objectives The aim of this study was to evaluate the effect serum albumin/globulin ratio (AGR) on 30-day mortality febrile neutropenia (FEN). second combination AGR with Multinational Association for Supportive Care in Cancer (MASCC) and Clinical Index Stable Febrile Neutropenia (CISNE) risk indexes FEN. Methods A retrospective evaluating AGR, MASCC CISNE scores FEN mortality. Results total 137 episodes 120 patients were included study. Nineteen (14%) died within first 30 days episodes. rate...
Introduction To evaluate biosimilar understanding and preference trends of medical oncologists in Turkey. Methods A survey consisting 24 multiple-choice questions with checkbox answers was conducted among oncologists. The questionnaire divided into five parts to some intentions: demographic characteristics, general knowledge about biosimilars, local approval reimbursement issues, individual trends, ranking the their own. All were analyzed as whole cohort, specialists fellows. Results Fellows...
ABS TRACT Objective:The vast majority of pancreatic carcinoma patients have unresectable or metastatic disease at the time diagnosis.Therefore, 5-year survival rate is approximately 10%.FOLFIRINOX used as a standard first-line therapy in with good performance status and single agent for poor performance.Our study aimed to compare combination FOLFIRINOX gemcitabine plus platinum-based treatment cancer.Material Methods: Patients diagnosed locally cancer Gazi University Hospital between 01.2012...
We investigated expressions of PD-L1, LAG-3, TIM-3, and OX40L as immune checkpoint proteins, MSI (repetitive short-DNA-sequences due to defective DNA-repair system) status were analyzed with immunohistochemistry from tissue blocks. Of 83 patients, PD-L1 expression was observed in 18.1% (n = 15) the patients. None patients exhibited LAG-3 expression. TIM-3 4.9% 4), 22.9% 19), 8.4% 7) had tumor. A low-to-intermediate positive correlation between (rho: 0.333, p < 0.01). Although higher grade 3...
Abstract Background: In metastatic colorectal cancer (mCRC), the genetic structure and cell metabolism of primary tumor lesion might be different from lesions. It is thought that cell-level glucose may differ due to difference in RAS wild mutant mCRC patients’ prognosis. this study, we aimed compare 2-deoxy-2-[fluorine-18]-fluoro-D-glucose Positron Emission Tomography (18F-FDG PET/CT) uptake levels for KRAS mutation status primary-metastatic localization. Methods: Our study a retrospective...
Abstract Background Neoadjuvant treatment is the standard in locally advanced ESCC. However, optimal chemotherapy regimen not known. Method This a retrospective observational cohort study conducted with propensity score matching. Patients resectable ESCC from 13 tertiary centers Türkiye were screened between January 2011 and December 2021. We compared efficacy safety of neoadjuvant chemoradiotherapy CF CROSS regimens patients Results Three hundred sixty‐two screened. who received induction (...
Amaç: Metastatik mide kanseri sık görülen ve prognozu kötü olan bir hastalıktır. Bu yaygın hastalıkta prognozun basit tam kan sayımı ile tahmin edilmesi birçok çalışmada dikkatleri üzerine çekmiştir. Ancak çalışmaların sonuçları birbiriyle uyumlu değildir. çalışmanın amacı, ilerlemiş kanserli (İMK) hastalarda parametreleri hastalık arasındaki ilişkiyi değerlendirmektir.
 Gereç Yöntemler: Hastaların İMK tanısı anında herhangi tedavi almadan önce sayımları incelendi. Tam sayımından elde...
Inflammatory myofibroblastic tumors (IMTs) are mesenchymal solid tumors, in which anaplastic lymphoma kinase (ALK) gene rearrangement might be detected. A 48-year-old female presented with IMT of lung, treated surgery. After a 39-month disease-free survival metastatic recurrence was occurred involving soft tissues both infra- and supradiaphragmatic regions. The biopsies obtained from regions confirmed the ALK immunohistochemistry. Initial partial response observed early treatment course...
Introduction The geriatric patient population diagnosed with extensive stage small cell lung cancer (SCLC) is underrepresented in clinical studies. We aimed to evaluate the clinicopathological characteristics, first-line treatment patterns and outcomes of patients aged 65 years or older SCLC. Material methods In this multicenter, retrospective cohort study, older, extensive-stage SCLC, between January 2009 December 2021 were included. Patients who under age at time diagnosis did not develop...
S mall-cell lung cancer (SCLC) constituted nearly 10%- 15% of all cancers.It has an aggressive nature and a poor prognosis.Approximately 60%-70% patients have extensive stage disease (ES-SCLC) at the time diagnosis. [1]The platinum-etoposide regimen in non-Asian with ES-SCLC chemoradiotherapy (with Objectives: To compare efficacy safety rechallenge, topotecan CAV sensitive relapsed (SR)-SCLC.Methods: It was retrospective observational study.Patients SR-SCLC from three oncology centers were...