A5030059105- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Pancreatic and Hepatic Oncology Research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Neuroendocrine Tumor Research Advances
- Pancreatitis Pathology and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatitis C virus research
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Diseases and Immunity
- Cancer, Hypoxia, and Metabolism
- Viral-associated cancers and disorders
- Gastrointestinal disorders and treatments
- Transplantation: Methods and Outcomes
- Renal Transplantation Outcomes and Treatments
- Cancer-related gene regulation
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Neuroblastoma Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetic and Kidney Cyst Diseases
- Cancer Diagnosis and Treatment
- Lipid metabolism and disorders
Ege University
2014-2024
Selçuk University
2024
Kastamonu University
2024
State Hospital
2024
Sağlık Bilimleri Üniversitesi
2020-2023
Ankara Onkoloji Eğitim ve Araştırma Hastanesi
2023
University of Health Science
2023
Gazi University
2023
Ege Üniversitesi Tıp Fakültesi Hastanesi
2006-2022
Bursa Yuksek Ihtisas Egitim Ve Arastirma Hastanesi
2022
The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), 13th (Vancouver, British Columbia, Canada, October 2015) meetings of Conference Pathology. Discussion continued online. primary goal was to introduce guidelines consensus criteria for diagnosis provide a comprehensive update all Schema recommendations....
The value of late protocol biopsies after liver transplantation remains to be evaluated highlight the therapeutic policies. study population was composed patients who survived with initial graft and an available 10-year biopsy (n = 143). long-term histologic outcome graft, particularly rate ductopenia in cases chronic rejection (CR), Metavir scoring fibrosis viral hepatitis (VCH), were assessed. Fibrosis progression (FP) rates compared over 3 periods (0-5, 5-10, 0-10 years). At 10 years,...
To investigate the efficacy of insulin-sensitizing agents in nonalcoholic fatty liver disease (NAFLD) patients.This is an open-label, randomized, a single-center study. Sixty-four patients, with impaired glucose metabolism and elevated alanine aminotransferase for at least 6 months before enrollment NAFLD activity score 5 biopsy, were randomized as group 1 received metformin 1700 mg/day, 2 rosiglitazone 4 3 combination mg/day 12 months.Baseline demographic laboratory findings similar all...
Caveolin-1 is the main component of caveolae membrane structures and has different roles during tumorigenesis in cancer types with varying expression profiles, indicating that role caveolin-1 varies according to tumor type. In this study, we investigated hepatocellular carcinogenesis.We analyzed 96 carcinoma (HCC), 29 cirrhosis, 20 normal liver tissues 9 HCC cell lines by immunostaining western blotting, respectively. After was stably transfected HepG2 Huh7 cells, effects on cellular...
Matrix metalloproteinases (MMPs) are known to play an important role in cell migration during cancer invasion by degrading extracellular matrix proteins. This study aimed determine the of MMP-9 hepatocellular carcinoma (HCC) carcinogenesis. Eighty-nine cases who underwent liver transplantation for HCC cirrhotic were selected this study. The tumor characteristics such as nodule number, maximal diameter, portal vein invasion, and preoperative alpha-fetoprotein levels reviewed. intensity...
Fibrolamellar carcinoma has a distinctive morphology and immunophenotype, including cytokeratin 7 CD68 co-expression. Despite the distinct findings, accurate diagnosis of fibrolamellar continues to be challenge. Recently, carcinomas were found harbor characteristic somatic gene fusion, DNAJB1-PRKACA. A break-apart fluorescence in situ hybridization (FISH) assay was designed detect this fusion event examine its diagnostic performance large, multicenter, multinational study. Cases initially...
Abstract Based on characterization of both genomic and expression status WT1 CTNNB1 (β‐catenin) in a series 60 Wilms tumor samples, combined with genome‐wide profiling these tumors, normal mature fetal kidney controls, we show that WT1/β‐catenin was better classifier than / mutations. We present molecular data supporting the WNT pathway is involved classes, without alterations. In class alterations, identified overexpression 14 previously unreported target genes, including TWIST1 . protein...
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related mortality worldwide. Deregulation AKT signaling pathway has been found in HCC. However, effect activation on proliferation and apoptosis HCC not clear. Herein, expression phosphorylated form (Ser 473) was investigated tumor (n=73), cirrhosis (n=17), normal liver (n=22) samples cell lines (n=8). The results showed that p-AKT higher (53%) than cirrhotic tissues (12%) while it absent (p<0.0001). also associated with...
In this study, we analyze the demographic features, clinical and histopathological findings in patients who underwent liver transplantation for progressive familial intrahepatic cholestasis. We also outcome impact of on growth bone mineral content. Most were presented with jaundice mainly beginning within first six months. At time initial admission; eight had short stature (height SD score<2), four weight score<2. Liver performed at age 43.2+/-27 months (range 9 to 96 months), 6.5+/-3.5...
The Banff Working Group on Liver Allograft Pathology met in September 2022. Participants included hepatologists, surgeons, pathologists, immunologists, and histocompatibility specialists. Presentations discussions focused the evaluation of long-term allograft health, including noninvasive tissue monitoring, immunosuppression optimization, structural changes. Potential revision rejection classification scheme to better accommodate communicate late T cell-mediated patterns related changes,...
c-Met, the receptor for Hepatocyte Growth Factor (HGF), overexpressed and deregulated in Hepatocellular Carcinoma (HCC). Caveolin 1 (CAV1), a plasma membrane protein that modulates signal transduction molecules, is also HCC. The aim of this study was to investigate biological clinical significance co-expression activation c-Met CAV1 We showed were co-localized HCC cells HGF treatment increased association. HGF-triggered caused concurrent rise both phosphorylation expression CAV1. Ectopic...
The term intracholecystic papillary-tubular neoplasm (ICPN) is suggested by some authors for a group of exophytic lesions the gallbladder. In our study, demographic, pathological, and immunohistochemical features 45 ICPN cases their relationship with invasive carcinoma were analyzed.A total retrieved out 7334 cholecystectomies performed between1996 2014. Cases evaluated regard to features. Correlation between clinical histopathological data occurrence invasion was sought.The incidence 0.61%...
Common variable immunodeficiency (CVID) has a heterogenous clinical presentation and can be challenging to diagnose. Distinct histologic changes have been linked with CVID in several organ systems, which help identify the correct diagnosis. In this study we review cohort of hepatic biopsies, better define spectrum biochemical alterations. We reviewed 26 liver biopsies from 24 patients CVID, obtained at 4 institutions between 2010 2019. Histologic slides were examined, pathologic,...
Nonalcoholic fatty liver disease (NAFLD) is a multisystem and significantly associated with obesity, insulin resistance, type 2 diabetes mellitus, metabolic syndrome, cardiovascular disease.NAFLD has become the most prevalent chronic in Western countries, proportion of NAFLD-related cirrhosis among patients on transplantation waiting lists increased.In light accumulated data about NAFLD, to provide common approach multi-disciplines dealing subject, it necessary create new guidance for...
Aim: Hepatocellular carcinoma (HCC) in patients with Metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) is expected to be a significant public health issue the near future. Therefore, understanding tumor microenvironment interactions MASLD-induced HCC crucial, and development of relevant preclinical models needed. Hence, we aimed determine effects MASLD-mimicking (ME) on aggressiveness cells identify target genes that drive by developing 3D-in vitro co-culture...
To investigate the macrophage migration inhibitory factor (MIF) expression and -173 G/C polymorphism of MIF gene in nonalcoholic fatty liver disease (NAFLD).Ninety-one patients with diagnosis NAFLD 104 healthy controls were included study. was detected using PCR-restriction fragment length based method. stratified as steatohepatitis (NASH), probable NASH steatosis, respectively groups 1, 2 3, according to Activity Score. by immunohistochemistry staining.Mean age 50.1+/-9.6 years, 54 them...
Autoimmune hepatitis (AIH) is a rare, immune-mediated liver disease. It has heterogeneous nature with varied clinical presentations. The management of patients AIH challenging in many ways. main difficulties are inexperience due to the rarity disease, diagnostic confusion controversial areas such as variant/overlap cases, acute presentations, presence non-alcoholic fatty disease or drug-induced injury features, and long complex course treatment. Here, we provide clear, concise, visualized...