A5014590093- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Pancreatitis Pathology and Treatment
- Gallbladder and Bile Duct Disorders
- Hepatitis C virus research
- Diet, Metabolism, and Disease
- Hepatitis B Virus Studies
- Lysosomal Storage Disorders Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet and metabolism studies
- Intestinal Malrotation and Obstruction Disorders
- Congenital Anomalies and Fetal Surgery
- Pancreatic and Hepatic Oncology Research
- Alcohol Consumption and Health Effects
- Viral-associated cancers and disorders
- Drug Transport and Resistance Mechanisms
- Endoplasmic Reticulum Stress and Disease
- Women's cancer prevention and management
- Carbohydrate Chemistry and Synthesis
- Head and Neck Cancer Studies
- Fungal Infections and Studies
- Metabolism and Genetic Disorders
- Bariatric Surgery and Outcomes
Hospital de Clínicas de Porto Alegre
2015-2024
Universidade Federal do Rio Grande do Sul
2015-2024
Hospital de Clínicas
2000-2018
Pontifícia Universidade Católica do Rio Grande do Sul
2007
University of Rio Grande and Rio Grande Community College
2003
Universidade Federal de Santa Maria
1992
The Banff Working Group on Liver Allograft Pathology reviewed and discussed literature evidence regarding antibody-mediated liver allograft rejection at the 11th (Paris, France, June 5-10, 2011), 12th (Comandatuba, Brazil, August 19-23, 2013), 13th (Vancouver, British Columbia, Canada, October 2015) meetings of Conference Pathology. Discussion continued online. primary goal was to introduce guidelines consensus criteria for diagnosis provide a comprehensive update all Schema recommendations....
Owing to concerns over the effects of physicochemical properties nanoparticles and their interaction with biological systems, further investigation is required. We investigated, for first time, toxicity lipid-core nanocapsules (LNCs) containing a polymeric wall poly(ɛ-caprolactone) coating polysorbate 80 used as drug delivery devices (~245nm) in Wistar rats after single- repeated-dose treatments. The suspensions were prepared by interfacial deposition polymer physicochemically characterized....
Background and aim Considering the increasing prevalence of non-alcoholic steatohepatitis (NASH) treatment gaps, this study aimed to evaluate effect probiotic supplementation on liver function markers, nutritional status, clinical parameters. Methods This double-blind, randomized trial ( ClinicalTrials.gov ID: NCT0346782) included adult outpatients with biopsy-proven NASH. The intervention consisted 24 weeks mix Lactobacillus acidophilus (1 × 10 9 CFU) + rhamnosus paracasei Bifidobacterium...
Background/Aim: The interactions between the gut and liver have been described in progression of non-alcoholic steatohepatitis (NASH). aim this study was to develop an experimental nutritional model NASH simulating metabolic changes occurring humans. Materials Methods: Adult male Sprague Dawley rats were randomized into two groups: controls (standard diet) intervention (high-fat choline-deficient for 16 weeks, each group with 10 animals. Biochemical analysis, hepatic lipid content,...
Cardiovascular disease (CVD) is the major cause of death in non-alcoholic fatty liver (NAFLD), a clinical condition without any approved pharmacological therapy. Probiotics are often indicated for disease, but their results controversial part due to poor quality studies. Thus, we investigated impact 24-week probiotics supplementation on cardiovascular risk (CVR) biopsy-proven steatohepatitis (NASH) patients. Double-blind, placebo-controlled, single-center study (NCT03467282), adult NASH,...
Background CD 44 and aldehyde dehydrogenase 1 ( ALDH 1) are considered putative markers of highly tumorigenic cells (i.e., cancer stem‐like cells) in head neck squamous cell carcinomas. This small subset is believed to be the primary responsible for tumor initiation progression. The objectives this study were (i) evaluate patterns expression center invasive front, as well adjacent non‐tumor epithelium, (ii) correlate these findings with clinical parameters. Materials methods sample comprised...
It is known that the inflammation process leading to oxidative stress and thyroid hormone metabolism dysfunction highly altered in metabolic associated with steatotic liver disease (MASLD). This study aims address effect of ornithine aspartate (LOLA) vitamin E (VitE) improving these processes. Adult Sprague-Dawley rats were assigned five groups treated for 28 weeks: controls (n = 10) received a standard diet (for weeks) plus gavage distilled water (DW) from weeks 16 28. MASLD high-fat...
Neonatal liver failure (NLF) is a major cause of neonatal morbidity and mortality, presenting as acute and/or congenital cirrhosis. Many affected patients show antenatal signs fetal injury. There are several causes NLF early diagnosis mandatory to elucidate the etiology determine specific treatment or best management strategy. Gestational alloimmune disease associated with hemochromatosis (GALD-NH) rare but potentially treatable NLF. It should be considered in any neonate postnatal no other...
Gaucher disease (GD) is a multisystemic disease. Liver involvement in GD not well characterised and ranges from hepatomegaly to cirrhosis hepatocellular carcinoma. We aim describe, assess the effect of treatment, on hepatic phenotype cohort patients with types I II. Retrospective study based review medical files Reference Centre Hospital de Clínicas Porto Alegre, Brazil. Data all III seen at centre since 2003 were analysed. Variables compared as pre- ("baseline") post-treatment...
Nuclear changes are typical in the carcinogenesis of hepatocellular carcinoma (HCC). Morphometry and chromatin texture analysis quantitative methods for their quantification. In this study, we analyzed nuclear morphometry parameters samples from liver transplant patients associations with clinicopathologic variables.Samples HCC adjacent tissue 34 individuals were collected microarray blocks. Stained slides microphotographed using an optical microscope ImageJ (FracLac plug-in). ROC curve was...
Abstract The aim of this study was to investigate biochemical and antioxidant parameters in alloxan‐resistant (ALR) alloxan‐susceptible (ALS) rats. Diabetes induced 60‐day‐old male Wistar rats by a single intraperitonial injection alloxan (AL, 150 mg/kg). Ten days after induction, group showed significant decrease glycemia. This named group. Susceptible remarkable increase the plasma lipid content, blood glucose HbA1. Glycogen content liver decreased significantly ALS (2.08 ± 0.41 mg%)...
Cardiovascular disease is the main cause of death in metabolic-associated fatty liver disease, and gut microbiota dysbiosis associated with both them.To assess relationship between cardiovascular risk (CVR) an experimental model steatohepatitis.Adult male Sprague-Dawley rats were randomized to a control group (n = 10) fed standard diet intervention high-fat choline-deficient for 16 wk. Biochemical, molecular, hepatic, cardiac histopathology. Gut variables evaluated.The had significantly...
The histopathology of the liver is fundamental for differential diagnosis between intra- and extrahepatic causes neonatal cholestasis. However, histopathological findings may overlap there disagreement among authors concerning those which could discriminate Forty-six biopsies (35 wedge 11 percutaneous biopsies) one specimen from a postmortem examination, all patients hospitalized cholestasis in Pediatrics Service Hospital de Clínicas Porto Alegre, were prospectively studied using specially...
Cardiovascular (CV) disease is the main cause of death in nonalcoholic fatty liver (NAFLD), a clinical condition without any approved pharmacological therapy. Thus, we investigated effects ornithine aspartate (LOLA) and/or Vitamin E (VitE) on CV parameters steatohepatitis experimental model. Adult Sprague Dawley rats were randomly assigned (10 animals each) and treated from 16 to 28 weeks with gavage as follows: controls (standard diet plus distilled water (DW)), NAFLD (high-fat...
Ischemia-reperfusion (I/R) injury is among the major causes of poor graft function early after liver transplantation that adversely influences patient survival. A variety mediators have been implicated in pathogenesis I/R vascular injury, including nitric oxide (NO). Because beneficial effects NO during preconditioning and reperfusion, strategies to prevent or ameliorate through stimulation hepatic production are an area significant clinical interest. We evaluated role...
To verify the frequency of postsurgical pelvic adhesion formation in an experimental animal model using videolaparoscopy.Experimental study a sample 11 non-pregnant female rabbits, aged 5 to 7 months. After general anesthesia, access abdominal cavity was performed by open puncture technique, with 10mm optics, placing two other mm trochars under direct visualization, iliac fossae. Then fragment peritoneum resected, followed electrocauterization. In 21 days, videolaparoscopy repeated, and...