A5060468184- Liver Disease Diagnosis and Treatment
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Diet, Metabolism, and Disease
- Pediatric Hepatobiliary Diseases and Treatments
- Intestinal Malrotation and Obstruction Disorders
- Diet and metabolism studies
- Gallbladder and Bile Duct Disorders
- Acute Ischemic Stroke Management
- Bone fractures and treatments
- Cardiovascular and Diving-Related Complications
- Connective tissue disorders research
- Traumatic Brain Injury and Neurovascular Disturbances
- Lipid metabolism and disorders
- Metastasis and carcinoma case studies
- Childhood Cancer Survivors' Quality of Life
- Gastrointestinal disorders and treatments
- CNS Lymphoma Diagnosis and Treatment
- Toxin Mechanisms and Immunotoxins
- Bone and Dental Protein Studies
- Educational Practices and Sociocultural Research
- Connexins and lens biology
- Healthcare Systems and Practices
- Aortic Disease and Treatment Approaches
- Craniofacial Disorders and Treatments
Geneva College
2024
Universidade Federal do Rio Grande do Sul
2017-2024
McMaster University
2018-2024
Population Health Research Institute
2024
University Hospital of Geneva
2024
Hospital de Clínicas de Porto Alegre
2015-2020
The George Institute for Global Health
2015
Ospedale Sacro Cuore Don Calabria
2015
Salford Royal NHS Foundation Trust
2015
Danderyds sjukhus
2015
Exploratory analysis of the phase 2 PACIFIC-Stroke (Program Anticoagulation via Inhibition FXIa by Oral Compound BAY 2433334-Non-Cardioembolic Stroke) randomized trial suggested that asundexian, an oral factor XIa inhibitor, prevents recurrent stroke and transient ischemic attacks in patients with atherosclerotic stroke. In this post hoc exploratory analysis, we hypothesized asundexian would be more effective enrolled large, multiple, or cortical acute infarcts on magnetic resonance imaging...
Background/Aim: The interactions between the gut and liver have been described in progression of non-alcoholic steatohepatitis (NASH). aim this study was to develop an experimental nutritional model NASH simulating metabolic changes occurring humans. Materials Methods: Adult male Sprague Dawley rats were randomized into two groups: controls (standard diet) intervention (high-fat choline-deficient for 16 weeks, each group with 10 animals. Biochemical analysis, hepatic lipid content,...
Osteogenesis imperfecta type V (OI-V) has a wide clinical variability, with distinct clinical/radiological features, such as calcification of the interosseous membrane (CIM) between radius-ulna and/or tibia-fibula, hyperplastic callus (HPC) formation, dislocation radial head (DRH), and absence dentinogenesis (DI). Recently, single heterozygous mutation (c.-14C>T) in 5'UTR IFITM5 gene was identified to be causative for OI-V. Here, we describe 7 individuals from 5 unrelated families that carry...
We investigated the association between non-syndromic oral cleft and variants in IRF6 (rs2235371 rs642961) 8q24 region (rs987525) according to ancestry contribution of Brazilian population.Subjects with (CL, CLP, or CP) their parents were selected from different geographic regions Brazil. Polymorphisms genotyped using a TaqMan assay genomic was estimated panel 48 INDEL polymorphisms.A total 259 probands analyzed. A TDT detected overtransmission rs2235371 G allele (P = 0.0008) sample....
BACKGROUND Prevalence of hepatocellular carcinoma (HCC) is increasing, especially in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). AIM To investigate rifaximin (RIF) effects on epigenetic/autophagy markers animals. METHODS Adult Sprague-Dawley rats were randomly assigned (n = 8, each) and treated from 5-16 wk: Control [standard diet, water plus gavage vehicle (Veh)], HCC [high-fat choline deficient diet (HFCD), diethylnitrosamine (DEN) drinking Veh gavage],...
Hairy cell leukemia (HCL) is a rare B-cell neoplasm comprising about 2% of lymphoid leukemias1 with pronounced male predominance.1–3⇓⇓ The majority patients present splenomegaly, pancytopenia, and circulating hairy cells in the peripheral blood.2–4⇓⇓ Peripheral lymphadenopathy but may be encountered on CT imaging up to 30% patients.2 Modern therapies, especially application cladribine (2CdA), lead durable complete remissions even after one single course treatment.2–4⇓⇓ Neurologic...
Introduction: The consumption of fructose has been questioned, since its increase led to an associated in steatosis caused by nonalcoholic fatty liver disease. Despite the advantages presented zebrafish as animal model, at present there are no models adult zebrafish. aim this study is establish a model hepatic zebrafish.Methods: Firstly, were daily exposed 4% or 6% fructose. Then, animals every 2 days. lipid accumulation was analyzed Nile Red and Oil O staining.Results: exposure showed...
Aim. To evaluate the effects of rifaximin through microbiota modulation in a model hepatocellular carcinoma secondary to non-alcoholic fatty liver disease. Methods. Three groups 8 adult male Sprague-Dawley rats each were divided as follows: HCC group: fed high-fat and choline-deficient diet plus diethylnitrosamine carcinogen, treated with control animals standard water. The euthanized after 16 weeks. We performed analyses pathology for disease severity cancer grading, gene expression...
Abstract Background Metabolic dysfunction-associated fatty liver disease (MASLD) is a common condition associated with increased cardiovascular (CVD) risk. Cytokeratin 18 (CK-18) indicative of injury and used as surrogate biomarker covering MASLD to cirrhosis phenotypes. Autoantibodies against apolipoprotein A-1 (AAA-1) are known CVD risk factors inducing in vitro, but their role modulating steatohepatitis fibrosis vivo still elusive. We investigated AAA-1's contribution systemic low-grade...
Metabolic dysfunction-associated fatty liver disease (MASLD) is a common and health issue associated with heightened cardiovascular (CVD) risk, Cytokeratin 18 (CK-18) as marker of injury across the MASLD to cirrhosis spectrum. Autoantibodies against apolipoprotein A-1 (AAA-1s) predict increased CVD promoting atherosclerosis steatosis in apoE-/- mice, though their impact on inflammation fibrosis remains unclear. This study examined AAA-1s' low-grade inflammation, steatosis, using mouse model...
Biliary atresia (BA) seems to be a multifactorial disorder in which environmental factors interact with the patient's genetic constitution.This study aimed analyze information concerning risk associated BA southern Brazil.A case-control mothers of patients and cystic fibrosis (CF) was conducted.Inquiry included questions related exposition during periconceptional gestational (second third trimesters) periods.Mothers had smoked pregnancy more frequently comparison CF patients, but no...